2017
DOI: 10.1088/1361-6560/aa950c
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Biological and dosimetric characterisation of spatially fractionated proton minibeams

Abstract: The biological effectiveness of proton beams varies with depth, spot size and lateral distance from the beam central axis. The aim of this work is to incorporate proton relative biological effectiveness (RBE) and equivalent uniform dose (EUD) considerations into comparisons of broad beam and highly modulated proton minibeams. A Monte Carlo model of a small animal proton beamline is presented. Dose and variable RBE is calculated on a per-voxel basis for a range of energies (30-109 MeV). For an open beam, the RB… Show more

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Cited by 21 publications
(26 citation statements)
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“…An accurate quantification of these physical quantities should be the subject of a future study, especially since the measurement of lineal energy distributions with new solid‐state (silicon or diamond) microdosimeters now appears to be accessible . Lastly, EUD corrections could also be recommended when evaluating and comparing uniform with spatially fractionated irradiation geometries …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…An accurate quantification of these physical quantities should be the subject of a future study, especially since the measurement of lineal energy distributions with new solid‐state (silicon or diamond) microdosimeters now appears to be accessible . Lastly, EUD corrections could also be recommended when evaluating and comparing uniform with spatially fractionated irradiation geometries …”
Section: Discussionmentioning
confidence: 99%
“…52 Lastly, EUD corrections could also be recommended when evaluating and comparing uniform with spatially fractionated irradiation geometries. 53 A particularly interesting potential clinical application of pMBRT irradiations with pencil beam scanning would be management of intra-fraction motion during treatment delivery, as hypofractionation is typically a key objective of pMBRT (a few tens of grays per fraction, 5,6 ). In this work, mean dose-rates of 6 Gy/min were obtained for multislit conditions, allowing a dose of 60 Gy to be delivered within a reasonable treatment time of 10 min.…”
Section: Discussionmentioning
confidence: 99%
“…To interpret spatially fractionated dose distributions, the calculation of the equivalent uniform dose (EUD) has been suggested [26]. With the EUD concept, inhomogeneous dose distributions are assigned to a homogeneous dose that leads to the same clonogenic cell survival [27].…”
Section: Microbeam Arc Therapymentioning
confidence: 99%
“…15 Currently, proton preclinical platforms (E ≤ 50 MeV) are burgeoning, offering the technical precision required to deliver precise millimeter-sized beams to localized regions within rodents. [16][17][18] Small-animal radiotherapy research platforms mimicking accurately human radiotherapy conditions are needed to reproduce pathologies observed in patients (improvement of animal models) and better understand the therapeutic possibilities and toxicities of PT. Several studies already improved the beam delivery and dose calculation for focal irradiation in the rat brain with gamma rays 19 and image-guided x rays.…”
Section: Introductionmentioning
confidence: 99%