Biological and Cognitive Responses to an In Vivo Interpersonal Stressor: Longitudinal Associations with Adolescent Depression

Calhoun, Casey D.; Franklin, Joseph C.; Adelman, Caroline B.; Guerry, John D.; Hastings, Paul D.; Nock, Matthew K.; Prinstein, Mitchell J.

doi:10.1521/ijct.2012.5.3.283

Cited by 14 publications

(9 citation statements)

References 51 publications

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“…There is evidence that alterations of HPA axis responses associated with depression may also dissipate in conjunction with remission (Zorn et al, 2017). Conversely, alterations to HPA axis responses may precede future re-occurrence of depression (Calhoun et al, 2012). aken together the findings of the present study and others portray a dynamic and interactive relationship between HPA axis responses and depression.…”

Section: Discussionsupporting

confidence: 74%

Associations between symptoms of depression and anxiety and cortisol responses to and recovery from acute stress

Fiksdal

Hanlin

Kuras

et al. 2019

Psychoneuroendocrinology

169

100

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Background: Anxiety disorders and major depressive disorder (MDD) have been associated with increased and blunted HPA axis reactivity to social stress. However, research focusing on associations between HPA axis responses to stress and symptoms of anxiety and depression among individuals without a diagnosis remains an understudied area of research. Methods: One hundred forty-three adults (52% female) completed the Trier Social Stress est (TSST). Symptoms of depression and anxiety were assessed prior to the TSST using the anxiety and depression subscales of the Hospital Anxiety and Depression Scale (HADS). HPA axis responses were assessed by measuring salivary cortisol at baseline and following the TSST. Reactivity to and recovery from stress were assessed using multilevel growth modeling controlling for age, BMI, and sex among the full sample and a subset of cortisol responders (n=72). Results: Anxiety symptoms were positively associated with flatter recovery slopes among the full sample (t(122.3)=2.082, p=.039). Among cortisol responders, depression symptoms were associated with steeper reactivity (t(63.32)=2.53, p=.026) and recovery (t(58.75)=−2.20, p=.03). Anxiety symptoms were associated with marginally flatter reactivity (t(64.00)=−1.97, p=.053) and significantly flatter recovery (t(59.22)=2.29, p=.025). Conclusion: Symptoms of anxiety and depression among individuals without a psychiatric diagnosis are associated with blunted and exaggerated cortisol responses to and recovery from

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Section: Discussionsupporting

confidence: 74%

Associations between symptoms of depression and anxiety and cortisol responses to and recovery from acute stress

Fiksdal

Hanlin

Kuras

et al. 2019

Psychoneuroendocrinology

169

100

View full text Add to dashboard Cite

show abstract

“…Blunted and heightened stress reactivity, and sustained HPA activation, have deleterious effects on one's ability to carry out effective, or socially desirable, behavioral and affective responses to stressors (McEwen, 1998, 2000). Each of these markers of dysregulated HPA axis response also has been linked with related biological stress response processes (e.g., pro-inflammation) and with later psychopathology among youth (Calhoun et al, 2012; Hastings et al, 2011). In addition, adolescence may be a critical transition point where proximal and chronic symptom presentations correspond with different profiles of HPA dysregulation (Ruttle et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Relational victimization, friendship, and adolescents' hypothalamic–pituitary–adrenal axis responses to an in vivo social stressor

et al. 2014

Self Cite

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Adolescents’ peer experiences may have significant associations with biological stress-response systems, adding to or reducing allostatic load. This study examined relational victimization as a unique contributor to reactive hypothalamic–pituitary–adrenal (HPA) axis responses as well as friendship quality and behavior as factors that may promote HPA recovery following a stressor. A total of 62 adolescents (ages 12–16; 73% female) presenting with a wide range of life stressors and adjustment difficulties completed survey measures of peer victimization and friendship quality. Cortisol samples were collected before and after a lab-based interpersonally themed social stressor task to provide measures of HPA baseline, reactivity, and recovery. Following the stressor task, adolescents discussed their performance with a close friend; observational coding yielded measures of friends’ responsiveness. Adolescents also reported positive and negative friendship qualities. Results suggested that higher levels of adolescents’ relational victimization were associated with blunted cortisol reactivity, even after controlling for physical forms of victimization and other known predictors of HPA functioning (i.e., life stress or depressive symptoms). Friendship qualities (i.e., low negative qualities) and specific friendship behaviors (i.e., high levels of responsiveness) contributed to greater HPA regulation; however, consistent with theories of rumination, high friend responsiveness in the context of high levels of positive friendship quality contributed to less cortisol recovery. Findings extend prior work on the importance of relational victimization and dyadic peer relations as unique and salient correlates of adaptation in adolescence.

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“…To ensure that pre-task cortisol reflected resting HPA-axis activity, before the TSST participants underwent a pre-task relaxation period consisting of watching an emotionally neutral movie clip. The TSST included instructions for adolescents to pretend to audition for a reality show about how teenagers make friends and interact with other teens (Calhoun et al 2012). To be chosen for the reality show, participants were instructed to give a 3-min audition speech about this topic, immediately after a 1-min preparation period.…”

Section: Methodsmentioning

confidence: 99%

Multi-Level Risk Factors for Suicidal Ideation Among at-Risk Adolescent Females: The Role of Hypothalamic-Pituitary-Adrenal Axis Responses to Stress

Giletta

Calhoun

Hastings

et al. 2014

J Abnorm Child Psychol

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Adopting a multi-level approach, this study examined risk factors for adolescent suicidal ideation, with specific attention to (a) hypothalamic-pituitary-adrenal (HPA) axis stress responses and (b) the interplay between HPA-axis and other risk factors from multiple domains (i.e., psychological, interpersonal and biological). Participants were 138 adolescent females (Mage=14.13 years, SD=1.40) at risk for suicidal behaviors. At baseline, lifetime suicidal ideation and a number of risk factors were assessed (i.e., depressive symptoms, impulsiveness, pubertal status and peer stress). Participants were exposed to a psychosocial stress task and HPA-axis responses were assessed by measuring cortisol levels pre- and post-stressor. At 3 months post-baseline, suicidal ideation again was assessed. Using group-based trajectory modeling, three groups of cortisol stress-response patterns were identified (i.e., hyporesponsive, normative, and hyperresponsive). As compared to females in the normative and hyporesponsive group, females in the hyperresponsive group were more likely to report a lifetime history of suicidal ideation at baseline, above and beyond the effects of the other predictors. Moreover, as compared to females in the normative group, females in the hyperresponsive group were at increased risk for reporting suicidal ideation 3 months later, after controlling for prior ideation. No interactions between cortisol group and the other risk factors were significant, with the exception of a non-significant trend between impulsiveness and cortisol group on lifetime suicidal ideation. Findings highlight the importance of HPA-axis responses to acute stressors as a risk factor for suicidal ideation among adolescents.

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Biological and Cognitive Responses to an In Vivo Interpersonal Stressor: Longitudinal Associations with Adolescent Depression

Cited by 14 publications

References 51 publications

Associations between symptoms of depression and anxiety and cortisol responses to and recovery from acute stress

Associations between symptoms of depression and anxiety and cortisol responses to and recovery from acute stress

Relational victimization, friendship, and adolescents' hypothalamic–pituitary–adrenal axis responses to an in vivo social stressor

Multi-Level Risk Factors for Suicidal Ideation Among at-Risk Adolescent Females: The Role of Hypothalamic-Pituitary-Adrenal Axis Responses to Stress

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