Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease

Guo, Bao Jian; Bian, Zhaoxiang; Qiu, Hong; Wang, Yi Tao; Wang, Ying

doi:10.1111/nyas.13414

Cited by 92 publications

(57 citation statements)

References 69 publications

(115 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some plant-derived compounds such as artemisinin, taxol, camptothecin are the representative examples of natural’s gifts to medicine at present. Epidemiological surveys suggest that, the majority of patients with IBD receive traditional medicines ( Kong et al, 2005 ; Guo et al, 2017 ). Some natural products such as berberine ( Habtemariam, 2016 ), sophocarpidine ( Wang et al, 2012 ), indigo naturalis ( Wang Y. et al, 2017 ), andrographolide ( Liu et al, 2014 ), and curcumin ( Sreedhar et al, 2016 ) also exhibit efficacy in treating UC.…”

Section: Introductionmentioning

confidence: 99%

Periplaneta americana Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation

et al. 2018

Front. Pharmacol.

View full text Add to dashboard Cite

Periplaneta americana, a magic medicinal insect being present for over 300 million years, exhibits desirable therapeutic outcome for gastrointestinal ulcer treatment. Nowadays, P. americana ethanol extract (PAE) has been shown to ameliorate ulcerative colitis (UC) by either single-use or in combination with other therapeutic agents in clinics. However, its underlying mechanisms are still seldom known. Herein, we investigated the anti-UC activity of PAE by alleviating intestinal inflammation and regulating the disturbed gut microbiota structure in dextran sulfate sodium (DSS)-induced UC rats. Based on multiple constitute analyses by HPLC for quality control, PAE was administrated to DSS-induced UC rats by oral gavage for 2 weeks. The anti-UC effect of PAE was evaluated by inflammatory cytokine production, immunohistochemical staining, and gut microbiota analysis via 16S rRNA sequencing. As a result, PAE remarkably attenuated DSS-induced UC in rats. The colonic inflammatory responses manifested as decreased colonic atrophy, intestinal histopathology scores and inflammatory cytokines. In addition, PAE improved the intestinal barrier function via activating Keap1/Nrf-2 pathway and promoting the expressions of tight junction proteins. It was observed that the UC rats showed symptoms of gut microbial disturbance, i.e., the increased Firmicutes/Bacteroidetes ratio and the significantly decreased probiotics such as Lactobacillus, Roseburia, and Pectobacterium, which were negatively correlated with these detected pro-inflammatory cytokines (secreted by immune CD4+ T cells, and including IFN-γ, TNF-α, IL-6, IL-8, IL-17, IL-1β). Besides, PAE administration regulated the abnormal intestinal microbial composition and made it similar to that in normal rats. Therefore, PAE could attenuate the DSS-induced UC in rats, by means of ameliorating intestinal inflammation, improving intestinal barrier function, and regulating the disturbed gut microbiota, especially improving beneficial intestinal flora growth, modulating the flora structure, and restoring the intestinal-immune system.

show abstract

Section: Introductionmentioning

confidence: 99%

Periplaneta americana Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation

et al. 2018

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Biological drugs, such as infliximab and adalimumab, have shown great potential as therapeutics for IBD; however, their exorbitant costs and potential for serious adverse effects limit their long-term use. Recently, much attention has been focused on the inhibitory effects of some active ingredients from natural herbs on inflammatory responses in human IBD or experimental colitis ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

The protective effects of magnolol on acute trinitrobenzene sulfonic acid‑induced colitis in rats

Zhang

Fu²,

Tang

2017

Mol Med Report

View full text Add to dashboard Cite

The present study aimed to investigate the protective effects of magnolol on acute 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis, and its underlying mechanisms. Experimental colitis was induced by intracolonic administration of TNBS/ethanol into rats. The model rats were randomly assigned into groups: TNBS, magnolol (high, medium and low doses), and salazosulfapyridine (positive control). All intervention regimens were administered by oral gavage, once a day for 7 consecutive days, 24 h after colitis induction. Histological and biochemical changes in colonic inflammation were evaluated by hematoxylin and eosin and immunohistochemistry, respectively. Rats treated with all doses of magnolol exhibited decreased colonic myeloperoxidase activity (P<0.05 vs. TNBS), reduced serum levels of proinflammatory cytokines [including interleukin (IL)-6 and IL-17], and downregulated Toll-like receptor-4 (TLR-4) mRNA expression. Histological analysis revealed that medium and high doses of magnolol conferred an anti-inflammatory effect, which was indicated by a decrease in disease activity index, an increase in thymus index, and downregulation of nuclear factor (NF)-κB p65 mRNA and TLR-4 protein expression. However, only high-dose magnolol significantly ameliorated the elevated colon weight/length ratio. The results of the present study indicate that magnolol exerts protective effects against acute TNBS-induced colitis in rats, and the TLR-4/NF-κB signaling pathway-mediated inhibitory effect on inflammatory cascades may contribute to the protective activity of magnolol.

show abstract

“…De nombreux produits naturels et herbes médicinales ont étéé tudiéss ur des modèles murins et chez l'homme en étude pré-clinique. Une revue récente de la littérature ar egroupé les différents produits selon leur mécanisme d'action [11] :…”

Section: Différentes Classes Phytothérapieunclassified

Thérapies complémentaires et alternatives : quelle place dans les maladies inflammatoires chroniques intestinales ?

Andrianjafy¹,

Peyrin–Biroulet²

2018

Hegel

View full text Add to dashboard Cite

Thérapies complémentaires et alternatives : quelle place dansl es maladies inflammatoires chroniques intestinales ? What is the place of complementary and alternative therapies in the managemento fi n fl ammatory bowel disease? CharlotteA ndrianjafy, Laurent Peyrin-Biroulet Service d'hépato-gastro-entérologie, Centre Hospitalo-Universitaire de Nancy,1a lléed uM orvan, 54000 Vandoeuvre-les-Nancy

show abstract

Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease

Cited by 92 publications

References 69 publications

Periplaneta americana Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation

Periplaneta americana Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation

The protective effects of magnolol on acute trinitrobenzene sulfonic acid‑induced colitis in rats

Thérapies complémentaires et alternatives : quelle place dans les maladies inflammatoires chroniques intestinales ?

Contact Info

Product

Resources

About