Biological and Clinical Aspects of Lanthanide Coordination Compounds

Gudi, Ravindra D.; Gagnani, Minaz A.; Devi, M.; Shukla, Ram S.

doi:10.1155/s1565363304000111

Cited by 71 publications

(30 citation statements)

References 4 publications

(7 reference statements)

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“…It is entirely reasonable to anticipate that the side-chain carboxylate group acts in the same capacity. Indeed, the use of Asp and Glu afforded respectively [Dy 4 (μ 3 -OH) 4 (Asp) 3 Figure 9.…”

Section: Lanthanide-amino Acid Complexes Obtained Under Hydrolytic Comentioning

confidence: 99%

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Lanthanides: Amino Acid Compounds

Zheng

2012

Encyclopedia of Inorganic and Bioinorganic Chemistry

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The synthetic and structural chemistry of lanthanide complexes with α‐amino acids under low‐ and high‐pH conditions is summarized. The preparative methods, diverse coordination modes, fascinating solid‐state structures, and solution behavior of such complexes are discussed. Under acidic conditions, only the carboxylate group of the amino acid participates in the metal coordination. For those with a side‐chain carboxylate group, more extensive bridging interactions of the ligand and the lanthanide ions are identified. Under physiological or even higher‐pH conditions, both the amino and carboxylate groups, be they skeletal or present in the side chain, could be coordinating, leading to much more diverse coordination modes of these unique ligands in their lanthanide complexes. Distinct from their low‐pH counterparts, complexes obtained under higher‐pH conditions are products of lanthanide hydrolysis, limited by the supporting amino acid ligands. Presence of structurally well‐defined polynuclear lanthanide–oxo/hydroxo cluster motif is characteristic of these interesting compounds that provide fundamental insight into the lanthanide interactions with biological environment.

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Section: Lanthanide-amino Acid Complexes Obtained Under Hydrolytic Comentioning

confidence: 99%

“…3 For example, [Gd(DTPA)] 2− (DTPA: diethylenetriaminepentaacetate) has been used as a contrast-enhancing agent in clinical MRI. 4-6 Luminescent lanthanide complexes have long been used as probes for time-resolved immunoassays.…”

Section: Introductionmentioning

confidence: 99%

Lanthanides: Amino Acid Compounds

Zheng

2012

Encyclopedia of Inorganic and Bioinorganic Chemistry

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“…[8][9][10][11][12][13][14][15][16][17] In recent years, new experimental methods have been developed due to which new data on the role of lanthanides in the biochemical processes operating in cellular membranes, organelles and cytoplasm have been obtained. [8][9][10][11][12][13][14][15][16][17] In pursuit better of understanding of the chelating behavior of some N, N, O and N, N, S donor semicarbazones and thiosemicarbazones in metal complexes our [4][5][6][7][18][19][20][21][22][23][24][25][26][27][28][29] and other [30][31] research groups have acquired more information about their nature of coordination behavior, structures, spectral [4][5][6][7][18][19][20][21][22]…”

Section: Introductionmentioning

confidence: 99%

“…Their potential pharmaceutical values have received attention as well. [8][9][10][11][12][13][14][15][16][17] The antibacterial activities of the present Lanthanide(III) complexes and tetracycline standard drug were also screened by agar-cup method in DMF solvent at a concentration of 50 µg mL -1 .…”

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confidence: 99%

Studies on the Effect of Picolines on the Stereochemistry of Lanthanide(III) Nitrate Coordination Compounds of 4[N-Furfural)amino]antipyrine Semicarbazone and Antibacterial Activities

Agarwal¹,

Agarwal²,

Prasad³

et al. 2011

Journal of the Korean Chemical Society

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ABSTRACT. The effect of α-, β-and γ-picolines on the stereochemistry of the coordination compounds of lanthanide(III) nitrates derived from 4[N-(furfural)amino]antipyrine semicarbazone (FFAAPS) has been studied. The general composition of the present coordination compounds is [Ln(FFAAPS)(NO3)3Pic] (Ln=La, Pr, Nd, Sm, Gd, Tb, Dy or Ho and Pic=α-, β-or γ-picolines). All these coordination compounds have been characterized by elemental analyses, molecular weight, molar conductance, magnetic susceptibility, infrared and electronic spectra. The infrared studies suggest that the FFAAPS behaves as a neutral tridentate ligand with N, N, O donor while α-, β-or γ-picoline is coordinated to the lanthanide(III) ions via heterocyclic N-atom. Nitrates are bicovalently bonded in these compounds. From the electronic spectral data, nephelauxetic effect (β), covalence factor (b 1/2 ), Sinha parameter (δ%) and the covalence angular overlap parameter (η) have been calculated. Thermal stabilities of these complexes have been studied by thermogravimetric analysis. The coordination number of lanthanide(III) ions in the present compound is found to be ten. The antibacterial studies screening of the primary ligand FFAAPS and the complexes showed that the present complexes have moderate antibacterial activities.

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“…On the one hand, this is caused by the creation of new high sensi tive methods for the analysis of bioobjects on the basis of the luminescent properties of lanthanide complexes [5] and, on the other hand, by the prospects of the application of these complexes as medicines [6][7][8]. Moreover, studies of lanthanide ion complexes give interesting information on the coordination abilities of bioligands.…”

mentioning

confidence: 99%

Hydrolysis constants of tervalent lanthanum and lanthanide ions in 0.1 M KNO3 solution

Yakubovich

Алексеев

2012

Russ. J. Inorg. Chem.

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In recent years, the growing interest is observed in studying lanthanide complexes with bioligands, such as anions of amino acids and peptides [1], tetracycline [2], quinolone [3], and β lactam [4] antibiotics, and other bioactive and medicinal substances. On the one hand, this is caused by the creation of new high sensi tive methods for the analysis of bioobjects on the basis of the luminescent properties of lanthanide complexes [5] and, on the other hand, by the prospects of the application of these complexes as medicines [6][7][8]. Moreover, studies of lanthanide ion complexes give interesting information on the coordination abilities of bioligands. As a rule, lanthanide complexes with bioligands are formed in a neutral or weakly alkaline medium, thus requiring the hydrolysis of Ln 3+ ions to be correctly taken into consideration and the hydroly sis constants K h determined under the same experi mental conditions to be introduced into computa tional equations.The hydrolysis of Ln 3+ ions have been studied repeatedly. A review of the works published on this topic before 1977 is given in [9]. Later obtained results are reviewed in . However, K h values estimated in most of these works can usually not be used to study complexation processes, as they were determined under other conditions (at a very high or low ionic strength and a temperature different from 25°С). In many cases, data were obtained for only some ions instead of the entire series of lanthanides. The thermo dynamic hydrolysis constants obtained in some works via referring values to zero ionic strength have different values (Table 1).Having the further study of complexation of lan thanide(III) ions with a number of bioligands in the view, in this work we were intended to estimate the hydrolysis constants of Ln 3+ ions at 25°С by pH titra tion against the background of 0.1 M KNO 3 , that is, under the conditions typical for studying complex ation in solutions. EXPERIMENTAL 0.05 M Ln(NO 3 ) 3 solutions (where Ln is La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, or Lu) were prepared from weighed portions of recrystallized Ln(NO 3 ) 3 ⋅ 6H 2 O salts and standardized by complexo metric titration. The purity of Ln(NO 3 ) 3 ⋅ 6H 2 O sam ples was monitored by X ray fluorescence spectros copy on a Spectroscan Max G. spectrometer. A 0.1 M KNO 3 solution was prepared from a weighed portion of KNO 3 (chemically pure grade). A 0.0429 M NaOH solution was prepared from a weighed portion of metallic sodium and standardized by the pH titration of a weighed portion of potassium biphthalate. All solutions were prepared with the use of bidistilled water previously boiled to remove CO 2 . pH was mea sured on a Microtechna M120 ion meter equipped with a Crytur 01 21 measuring glass electrode and a Radelkis OP 0830P saturated calomel reference elec trode. The system was calibrated against buffer solu tions of Na 2 B 4 O 7 (pH 9.18 at 25°С) and KH 3 (C 2 O 4 ) 2 (pH 1.68 at 25°С). The pH measurement accuracy was ±0.01.A 0.1 M KNO 3 solution (100 mL) and a Ln(NO 3 ) 3 s...

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Biological and Clinical Aspects of Lanthanide Coordination Compounds

Cited by 71 publications

References 4 publications

Lanthanides: Amino Acid Compounds

Lanthanides: Amino Acid Compounds

Studies on the Effect of Picolines on the Stereochemistry of Lanthanide(III) Nitrate Coordination Compounds of 4[N-Furfural)amino]antipyrine Semicarbazone and Antibacterial Activities

Hydrolysis constants of tervalent lanthanum and lanthanide ions in 0.1 M KNO3 solution

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