Biological and Clinical Aspects of Transfer Factor

Study of the Immunopotentiator Effects of Dialyzable Leukocyte Extracts Obtained Out of Leukocytes Previously Used for Interferon Production

“…In some patients the DLE effects are dramatic and in others apparently afflicted with the same clinical syndrome the results are totally neg ative. These controversial observations, which were made for instance in cases of generalized candidiasis [ Theoretically it is hard to admit that for the purposes of the treatment of a complex immunodeficiency with generalized lack of response to nearly all known antigens, the frequently reported beneficial effects of DLE [5] were due to the transfer to the patients of relevant antigen-specific responsiveness.…”

“…The three different types of leukocytes were pro cessed to obtain DLE by the methodology described in detail earlier [1][2][3][4][5]. In the cases of DLE-NS and DLE-NS-I the solutions containing DLE were mixed with equal volumes of 94% ethanol at 4"C, mixed and allowed to precipitate for 1 h at 4 "C. The precipitate was removed by centrifugation at 2,000 g for 10min and discarded.…”

Immunostimulation: Synthetic and Biological Modulators of Immunity

“…OLE has received widespread clinical use [reviewed in (48)]. Although few clinical trials have been double-blind, the results obtained in some viral, fungal, and other diseases have been striking.…”

“…OLE was first applied as a therapeutic and prophylactic agent in patients with Wiskott-Aldrich syndrome (49), an X-linked deficiency of cellular immunity in which death invariably occurred before age 20. Other genetically determined immune de ficiencies treated successfully with OLE include severe combined immunodefi ciency disease, ataxia telangiectasia, genetically determined antigen-selective defects with recurrent infections, recurrent shingles and refractory cytomegalo virus, candida infection, and others (48). Other genetically determined immune de ficiencies treated successfully with OLE include severe combined immunodefi ciency disease, ataxia telangiectasia, genetically determined antigen-selective defects with recurrent infections, recurrent shingles and refractory cytomegalo virus, candida infection, and others (48).…”

“…especially diseases due to agents handled by T cells) also have been treated with OLE (48). especially diseases due to agents handled by T cells) also have been treated with OLE (48).…”