Biological activity, phytochemistry and traditional uses of genus Lobelia (Campanulaceae): A systematic review

Folquitto, Daniela Gaspardo; Swiech, Juliane Nadal Dias; Pereira, Camila Bugnotto; Bobek, Vanessa Barbosa; Halila, Gerusa Clazer; Farago, Paulo Vítor; Miguel, Marilis D.; Duarte, Juliana Lúcia; Miguel, Obdúlio Gomes

doi:10.1016/j.fitote.2018.12.021

Cited by 18 publications

(12 citation statements)

References 47 publications

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“…Lobetyolin was discovered in the early 1990s from C. pilosula [24] and from the plant Lobelia inflata which is also a Campanulaceae [25]. Later, the compound was fully characterized from C. pilosula extracts [26,27] and isolated from hairy roots cultures of several Lobelia species [28][29][30][31][32]. The induction of hairy roots by Agrobacterium rhizogenes is a convenient procedure to enhance considerably the production of lobetyol and lobetyolin [33].…”

Section: Lobetyolin and Related Polyacetylene Glycosidesmentioning

confidence: 99%

Anticancer Properties of Lobetyolin, an Essential Component of Radix Codonopsis (Dangshen)

Bailly

2020

Nat. Prod. Bioprospect.

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Lobetyolin (LBT) is a polyacetylene glycoside found in diverse medicinal plants but mainly isolated from the roots of Codonopsis pilosula, known as Radix Codonopsis or Dangshen. Twelve traditional Chinese medicinal preparations containing Radix Codonopsis were identified; they are generally used to tonify spleen and lung Qi and occasionally to treat cancer. Here we have reviewed the anticancer properties of Codonopsis extracts, LBT and structural analogs. Lobetyolin and lobetyolinin are the mono- and bis-glucosylated forms of the polyacetylenic compound lobetyol. Lobetyol and LBT have shown activities against several types of cancer (notably gastric cancer) and we examined the molecular basis of their activity. A down-regulation of glutamine metabolism by LBT has been evidenced, contributing to drug-induced apoptosis and tumor growth inhibition. LBT markedly reduces both mRNA and protein expression of the amino acid transporter Alanine-Serine-Cysteine Transporter 2 (ASCT2). Other potential targets are proposed here, based on the structural analogy with other anticancer compounds. LBT and related polyacetylene glycosides should be further considered as potential anticancer agents, but more work is needed to evaluate their efficacy, toxicity, and risk–benefit ratio.

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Section: Lobetyolin and Related Polyacetylene Glycosidesmentioning

confidence: 99%

Anticancer Properties of Lobetyolin, an Essential Component of Radix Codonopsis (Dangshen)

Bailly

2020

Nat. Prod. Bioprospect.

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“…Though there is no literature reporting on the healing properties of Lobelia alsinoides Lam. The pharmacological aspects of Lobelia species under the Campanulaceae family have been reported 68 . Few studies on Lobelia chinensis, Lobelia flaccida (C.Presl), and Lobelia laxiflora L. belonging to the same genus were reported to show anti‐inflammatory activity 69,70 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy ofLobelia alsinoidesLam ethanolic extract on a third‐degree burn: An experimental study on rats

Thanapaul

Ranjan

Manikandan

et al. 2020

Dermatologic Therapy

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This is the first study to evaluate the topical application of Lobelia alsinoides Lam (LT) ethanolic extract on burns in rats. A deep third-degree burn wound was inflicted in adult male Wistar rats and the burns were dressed daily with a topical ointment formulation (Patent filed) comprising of Lobelia alsinoides Lam (5% and 10% w/w). The wound had noteworthy contraction and quicker eschar removal in 10% w/w LTtreated groups followed by 5% w/w treated groups on comparing with the commonly prescribed ointment (Silverex TM containing 1% w/w Silver sulfadiazine). Histopathological analysis showed that ointment containing 10% w/w LT ethanolic extract significantly increased fibroblast growth, which plays a major role in anatomic integrity, collagen synthesis, and accelerated the rate of the healing process. This study shows that the ethanolic extract of Lobelia alsinoides Lam, a previously pharmacologically unreported traditional medicinal plant, possesses wound contraction and eschar removal properties on burn wounds.

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“…These alkaloids ubiquitously contain N-methylpiperidine ring or piperidine ring along with one or two substituents at the C 2 and/or C 6 position of the ring (Felpin and Lebreton, 2004;Folquitto et al, 2019).…”

Section: Beyond Lobeline: Other Bioactive Alkaloidsmentioning

confidence: 99%

“…Moreover, to date, more than 80 alkaloids are known to be isolated from different species of Lobelia. The readers are recommended to the following review for the updates on other isolated alkaloids (Folquitto et al, 2019).…”

Section: Beyond Lobeline: Other Bioactive Alkaloidsmentioning

confidence: 99%

Beyond Alkaloids: Novel Bioactive Natural Products From Lobelia Species

2021

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In this work, we reviewed the progress in the phytochemical and biological investigations of bioactive components derived from medicinally valuable Lobelia species. In the last 60 years, Lobelia has garnered significant attention from the phytochemist from around the world, majorly due to the discovery of bioactive piperidine alkaloids (e.g., lobinaline and lobeline) in the early 1950s. Later, lobeline underwent clinical trials for several indications including the treatment of attention deficit hyperactivity disorder and a multicenter phase three trial for smoking cessation. Subsequently, several other alkaloids derived from different species of Lobelia were also investigated for their pharmacological characteristics. However, in the last few years, the research focus has started shifting to the characterization of the other novel chemical classes. The major shift has been noticed due to the structurally similar alkaloid components, which essentially share similar pharmacological, physicochemical, and toxicological profiles. In this review, we present an up-to-date overview of their progress with special attention to understanding the molecular mechanisms of the novel bioactive components.

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Biological activity, phytochemistry and traditional uses of genus Lobelia (Campanulaceae): A systematic review

Cited by 18 publications

References 47 publications

Anticancer Properties of Lobetyolin, an Essential Component of Radix Codonopsis (Dangshen)

Anticancer Properties of Lobetyolin, an Essential Component of Radix Codonopsis (Dangshen)

Efficacy ofLobelia alsinoidesLam ethanolic extract on a third‐degree burn: An experimental study on rats

Beyond Alkaloids: Novel Bioactive Natural Products From Lobelia Species

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