Biological Activity of S-Containing Monoterpenoids

Никитина, Л. Е.; Artemova, N. P.; Старцева, В. А.; Fedyunina, I. V.; Клочков, В. В.

doi:10.1007/s10600-017-2131-z

Cited by 22 publications

(17 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following the present study, many terpenes are active against various microorganisms, including gram-negative and gram-positive bacteria. In general, gram-positive bacteria are most sensitive to terpenes (NIKITINA & al [34]).…”

Section: Gc/ms Analysismentioning

confidence: 99%

Antibacterial efficacy and phytochemical characterization of some marine brown algal extracts from the red sea, Egypt

El‐Sheekh¹,

Mousa²,

Farghl³

2020

Rom Biotechnol Lett.

View full text Add to dashboard Cite

This study was carried out to evaluate the antibacterial activity of ethanol, methanol, acetone, and ethyl acetate extracts of the brown seaweeds, Cystoseira myrica, Padina boergesenii and Sargassum cinereum (Phaeophyta), as well as to identify the phytochemical constituents of the most effective algal extracts. Antibacterial activities were expressed as inhibition zones and minimum inhibitory concentrations (MICs) of the algal extracts. All seaweed extracts tested exhibited a broad spectrum of antibacterial activity. The maximum inhibition activities were recorded for methanolic extracts of P. boergesenii and ethyl acetate extracts of C. myrica and S. cinereum against Shigella flexneri, Staphylococcus aureus (MRSA) and Staphylococcus aureus, respectively. The MIC values of the marine algal extracts tested for inhibiting pathogenic bacteria ranged from 3.13 to 300 mg/ml. GC-MS and FTIR analyses of algal extracts revealed the chemical components and their functional constituents in the brown seaweeds that might have potent antimicrobial activities. These components include fatty acids esters, alcohols, phenols, amines-containing compounds and others. The results indicated that brown seaweeds may be main sources of phytoconstituents which exhibited antibacterial properties and will be helpful in diminishing the adverse effects of synthetic drugs.

show abstract

Section: Gc/ms Analysismentioning

confidence: 99%

Antibacterial efficacy and phytochemical characterization of some marine brown algal extracts from the red sea, Egypt

El‐Sheekh¹,

Mousa²,

Farghl³

2020

Rom Biotechnol Lett.

View full text Add to dashboard Cite

show abstract

“…Moreover, we also demonstrated the anti-fungal, anti-inflammatory, anti-helicobacter, antimicrobial and other types of activities of sulfur-containing monoterpenoids (Nikitina et al, 2009 , 2010 , 2012a , b ; Gavrilov et al, 2010 ). Coagulation activity of these compounds has already been described in our previous publications (Kiselev et al, 2017 ; Nikitina et al, 2017a , b ). We observed that all synthesized sulfur-containing monoterpenoids have a low toxicity, whereas mutagenic and genotoxic effects were not found (Nikitina et al, 2011 ).…”

Section: Introductionmentioning

confidence: 52%

“…Coagulation activity of these compounds has already been described in our previous publications (Kiselev et al, 2017 ; Nikitina et al, 2017a , b ). We observed that all synthesized sulfur-containing monoterpenoids have a low toxicity, whereas mutagenic and genotoxic effects were not found (Nikitina et al, 2011 ).…”

Section: Introductionmentioning

confidence: 52%

Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example

et al. 2018

View full text Add to dashboard Cite

In this article we present the synthesis of enantiomerically pure sulfoxide and study the influence of this compound on hemostasis. Detailed NMR studies and molecular dynamics simulations using sodium dodecyl sulfate (SDS) membrane models indicated that the bicyclic fragment of sulfoxide was embedded into the SDS micelle whereas the -SO(CH2)2OH fragment remained on the surface of the micelle and was in contact with the solvent. We also found that the pro-coagulative activity of sulfoxide was due to its ability to inhibit platelet activation and inhibited the catalytic activity of phospholipid surface which was involved in formation of coagulation clotting factor complexes.

show abstract

“…Sulfur‐containing monoterpenoids have a wide spectrum of biological activity. It is known that such compounds exhibit antifungal, [1] anti‐inflammatory, anti‐ulcer, [2] anti‐helicobacter, antitumor, antiparasitic activity, [3] and also have membrane‐protective, antioxidant, [4–9] antiplatelet, [10,11] antimicrobial properties [12,13] . The biological activity of these compounds also depends on the oxidation state of the sulfur atom [14] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Chiral CF₃‐Contaning Pinane‐Type Hydroxythiols

et al. 2021

View full text Add to dashboard Cite

For the first time, the isomeric trifluoromethylated thioacetates have been synthesized in 37–52 % yields by nucleophilic addition of the Ruppert‐Prakash reagent (TMSCF3) to the corresponding thioacetates based on (1R)‐(−)‐myrtenal and (1S)‐(−)‐verbenone. Thioacetates have been transformed into the corresponding pinane thiols in 73–90 % yields. The structure and configuration of the resulting compounds have been determined.

show abstract

Biological Activity of S-Containing Monoterpenoids

Cited by 22 publications

References 50 publications

Antibacterial efficacy and phytochemical characterization of some marine brown algal extracts from the red sea, Egypt

Antibacterial efficacy and phytochemical characterization of some marine brown algal extracts from the red sea, Egypt

Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example

Synthesis of Chiral CF₃‐Contaning Pinane‐Type Hydroxythiols

Contact Info

Product

Resources

About

Biological Activity of S-Containing Monoterpenoids

Cited by 22 publications

References 50 publications

Antibacterial efficacy and phytochemical characterization of some marine brown algal extracts from the red sea, Egypt

Antibacterial efficacy and phytochemical characterization of some marine brown algal extracts from the red sea, Egypt

Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example

Synthesis of Chiral CF3‐Contaning Pinane‐Type Hydroxythiols

Contact Info

Product

Resources

About

Synthesis of Chiral CF₃‐Contaning Pinane‐Type Hydroxythiols