Biological activity of recombinant human PDX1 protein produced from Escherichia coli
Gloria Narayan,
Plaboni Sen,
Shirisha Nagotu
et al.
Abstract:Pancreatic and duodenum homeobox 1 (PDX1) is considered as a pivotal transcription factor that acts as a “master regulator” in pancreatogenesis and maintenance of β‐cells. Earlier study has reported that PDX1 also functions as a tumor suppressor in human gastric cancer cells by inhibiting cell growth. Here, we report the bioactivity of the purified human PDX1 fusion protein using various assays like cell migration, proliferation, cell cycle analysis, and gene expression. In cancer cells, recombinant PDX1 prote… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.