Biological activity of Pinus nigra terpenes—Evaluation of FtsZ inhibition by selected compounds as contribution to their antimicrobial activity

Šarac, Zorica; Matejić, Jelena S.; Stojanović-Radić, Zorica; Veselinović, Jovana B.; Džamić, Ana M.; Bojović, Srdjan; Marin, Petar D.

doi:10.1016/j.compbiomed.2014.08.022

Cited by 40 publications

(33 citation statements)

References 28 publications

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“…They show antimicrobial activity toward many bacterial species. A docking model expects a binding position of the germacrene family to be a hydrophobic pocket in the FtsZ protein [86].…”

Section: Phenylpropanoids and Terpenoidsmentioning

confidence: 99%

The key bacterial cell division protein FtsZ as a novel antibacterial drug target

Rahman¹,

Wang²,

Wang³

et al. 2020

Bosn J of Basic Med Sci

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The number of multidrug-resistant bacterial strains is currently increasing; thus, the determination of drug targets for the development of novel antimicrobial drugs is urgently needed. FtsZ, the prokaryotic homolog of the eukaryotic tubulin, is a GTP-dependent prokaryotic cytoskeletal protein that is conserved among most bacterial strains. In vitro studies revealed that FtsZ self-assembles into dynamic protofilaments or bundles, and it forms a dynamic Z-ring at the center of the cell, leading to septation and consequent cell division. The potential role of FtsZ in the blockage of cell division makes FtsZ a highly attractive target for developing novel antibiotics. Researchers have been working on synthetic molecules and natural products as inhibitors of FtsZ. Accumulating data suggest that FtsZ may provide the platform for the development of novel antibiotics. In this review, we summarize recent advances on the properties of FtsZ protein and bacterial cell division, as well as on the development of FtsZ inhibitors.

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“…They show antimicrobial activity toward many bacterial species. A docking model expects a binding position of the germacrene family to be a hydrophobic pocket in the FtsZ protein [86].…”

Section: Phenylpropanoids and Terpenoidsmentioning

confidence: 99%

The key bacterial cell division protein FtsZ as a novel antibacterial drug target

Rahman¹,

Wang²,

Wang³

et al. 2020

Bosn J of Basic Med Sci

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“…For example, the sesquiterpene germacrene D (Fig. 2) interacts with FtsZ binding pocket, so it could be an important natural preservative [24].…”

Section: Terpenoids and Essential Oilsmentioning

confidence: 99%

Plant nutraceuticals as antimicrobial agents in food preservation: terpenoids, polyphenols and thiols

Gutiérrez-del-Río

Fernández

Lombó

2018

International Journal of Antimicrobial Agents

228

110

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“…The genus Pinus exhibits a taxonomical variety of about 115 species and occurs mainly in the northern hemisphere [ 1 , 2 , 3 , 4 ]. Needles and twigs are source of pine essential oils (EOs), used to treat respiratory infections based on their antibacterial, anti-inflammatory, expectorant and analgesic potential [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. EOs are mixtures of natural complex substances mainly categorized into monoterpenes, sesquiterpenes and their oxygenated derivatives and are synthesized as secondary metabolites [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Verification of Chromatographic Profile of Primary Essential Oil of Pinus sylvestris L. Combined with Chemometric Analysis

Allenspach

Valder²,

Flamm³

et al. 2020

Molecules

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Chromatographic profiles of primary essential oils (EO) deliver valuable authentic information about composition and compound pattern. Primary EOs obtained from Pinus sylvestris L. (PS) from different global origins were analyzed using gas chromatography coupled to a flame ionization detector (GC-FID) and identified by GC hyphenated to mass spectrometer (GC-MS). A primary EO of PS was characterized by a distinct sesquiterpene pattern followed by a diterpene profile containing diterpenoids of the labdane, pimarane or abietane type. Based on their sesquiterpene compound patterns, primary EOs of PS were separated into their geographical origin using component analysis. Furthermore, differentiation of closely related pine EOs by partial least square discriminant analysis proved the existence of a primary EO of PS. The developed and validated PLS-DA model is suitable as a screening tool to assess the correct chemotaxonomic identification of a primary pine EOs as it classified all pine EOs correctly.

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Biological activity of Pinus nigra terpenes—Evaluation of FtsZ inhibition by selected compounds as contribution to their antimicrobial activity

Cited by 40 publications

References 28 publications

The key bacterial cell division protein FtsZ as a novel antibacterial drug target

The key bacterial cell division protein FtsZ as a novel antibacterial drug target

Plant nutraceuticals as antimicrobial agents in food preservation: terpenoids, polyphenols and thiols

Verification of Chromatographic Profile of Primary Essential Oil of Pinus sylvestris L. Combined with Chemometric Analysis

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