Biological Activity of Hypericum Perforatum L. (Hypericaceae): A Review

Abstract

Федеральное государственное бюджетное учреждение науки Ботанический институт им. В.Л. Комарова Российской академии наук (БИН РАН) 197376, Россия, г. Санкт-Петербург, ул. проф. Попова, 2 2 Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет»

Comparison Between Omental and Hypericum Perforatum Extracts on Healing of Full Thickness Excisional Skin Wounds in Rabbits

“…The least infiltration of inflammatory cells at 7 day interval was observed in HD. These findings were due to the fact that Hypericum contain Hypericin, which inhibited the pro-inflammatory enzyme janus kinase 1 (JAK1), and Hyperforin which inhibit the activity of cyclooxygenases (COX) 1 and 2 and prostaglandin synthase PGE2, which explained the anti-inflammatory properties of Hypericum [11]. Little inflammatory infiltration that noted in some samples at 14 day interval was probably due to selfmutilation.…”

“…Hyperforin, Flavonoids and Hypericin), which possess many pharmaceutical effects, the H. perforatum has been used both topically and orally to treat many conditions including skin wounds [7,8]. Literatures showed that it increased deposition of collagen and shortened the duration of inflammatory phase [9,10], also it has antibacterial activity [11].…”

Screening for acetylcholinesterase inhibition, lipid peroxidation inhibition and antioxidant activity of medicinal plants from Morocco

“…Hypericum perforatum L. is native Europe, western Asia, and northern Africa, although currently it has a worldwide distribution. H. perforatum is a species largely known for its antidepressant-like properties, nevertheless other proprieties have been reported such as neuroprotective, nootropic, antimicrobial, antiviral and antiprotozoal, antiepileptic, anxiolytic, antitumor and cytotoxic properties, analgesic, antiinflammatory and woundhealing properties, hypolipidaemic and hypoglycaemic properties, among other attributes (Oliveira et al, 2016;Budantsev et al, 2021). According to the Kraus et al (2007), the plant extract of H. perforatum was able to restore or improve microglial viability and thereby attenuate amyloid-β mediated toxicity in Alzheimer's disease, even better than individual flavonoids.…”