Biological activity of Herissantia crispa (L.) Brizicky

Abstract

RESUMO: "Atividade biológica da Herissantia crispa (L.) Brizicky". O extrato metanólico bruto (EMeOH) das partes aéreas da Herissantia crispa (L.) Brizicky, planta rica em flavonóides e que não possui estudos farmacológicos, foi testada para avaliar sua atividade sob os parâmetros comportamentais e determinar a dose letal 50 (DL 50 ) em camundongos; atividade antimicrobiana e antiulcerogênica. O EMeOH (5000 mg/kg, v.o. ou 2000 mg/kg i.p.) não alterou os parâmetros comportamentais e não causou mortes nos animais. A amostra vegetal em estudo inibiu o crescimento bacteriano. O EMeOH (750 mg/kg) apresentou atividade anti-diarréica. O EMeOH (250, 500 e 750 mg/kg) foi capaz de inibir as lesões gástricas induzidas pelo 0,3 M HCl/etanol 60% em camundongos. Desta forma, pode-se concluir que a planta em estudo apresenta atividade antiulcerogênica, entretanto, se faz necessário avaliar tal atividade através de modelos mais específicos e estudar o mecanismo de ação pelo qual a amostra vegetal protege a mucosa gástrica.Unitermos: Herissantia crispa, Malvaecae, avaliação comportamental, atividade antibacteriana, atividade antiulcerogênica. ABSTRACT:The crude methanol extract (EMeOH) of the aerial parts of Herissantia crispa (L.) Brizicky, plant riches in flavonoids and without pharmacological studies, was tested to value its activity under the behaviour parameters and to determine the lethal dose (LD 50 ) in mice; antimicrobial and antiulcerogenic activities. The EMeOH (5,000 mg/kg, v.o. or 2,000 mg/kg i.p.) did not alter the behaviour parameters and there were not mice deaths. The extract inhibited the bacterial growth. The EMeOH (750 mg/kg) showed anti-diarroeal activity. The EMeOH (250, 500 and 750 mg/kg) decreased the gastric lesions induced by 0.3 M HCl/ethanol 60% in mice. In conclusion, the EMeOH presents anti-ulcerogenic activity;, however it is necessary to value the antiulcerogenic activity in more specific models and to study the action mechanism by which the vegetable sample protects the gastric mucosa.

The Gastroprotective Activity of Ethanol Extract of Curcuma domestica Val. on Mice Induced Ethanol - HCl

“…HCl caused severe damage to the gastric mucosa, while ethanol produces lesions necrosis with action necrosis directly reducing factors such defensive secretion of bicarbonate and mucus production (Alrashdi, et al, 2012), and increased acid secretion (Lima, et al, 2009). Ranitidine is an H2 receptor antagonist role in reducing gastric acid secretion by inhibiting the binding of histamine H2 receptor selectively (Aziz, 2002).…”

Phosphatidylinositide 3‐Kinase Contributes to the Anti‐Inflammatory Effect of Abutilon crispum L. Medik Methanol Extract

“…Traditionally, it is used in India for treatment of asthma, cough, diabetes, ulcers, and jaundice [8]. This plant is rich in flavonoids but has not been well studied with regard to pharmacology [9]. One of the studies found that Abutilon crispum L. Medik can be used as an anti-inflammatory agent through in vivo experiments, but the exact mechanism remains unknown [10].…”

Anti-inflammatory activity and participation of the glutamatergic system on the antinociceptive activity of ethyl acetate phase of Herisantia crispa (L.) Brizicky

“…In this context, this study aims to contribute to the inception of a therapeutic option, particularly from natural sources, which can be effective in removing the main signs and symptoms of inflammation and pain, diminishing the problems related to drug resistance and the various toxic and side effects caused by drugs currently available. Herissantia crispa, known as malvaísco, belongs to the Malvaceae family [1] and various effects are related to this plant: antiulcer [2], antimicrobial [2] and antinociceptive [3]. The aim of this study was to evaluate the anti-inflammatory activity and participation of the glutamatergic system in the antinociceptive effect of the ethyl acetate phase of Herissantia crispa (FAEHc).…”