Biological activity and photocatalytic properties of a naphthyl-imidazo phenanthroline (HNAIP) ligand and its [Ir(ppy)2(HNAIP)]Cl and [Rh(ppy)2(HNAIP)]Cl complexes

Rubio, Ana R.; Fidalgo, Jairo; Martin-Vargas, Judit; Pérez‐Arnaiz, Cristina; Alonso-Torre, Sara R.; Biver, Tarita; Espino, Gustavo; Busto, Natalia; Garcı́a, Begoña

doi:10.1016/j.jinorgbio.2019.110885

Cited by 11 publications

(2 citation statements)

References 53 publications

(59 reference statements)

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“…1,2 In recent decades, organometallic rhodium(III) complexes have received considerable interest in the scientific literature due to their particular biological properties. [3][4][5] Although the rhodium(III) center is regarded to be kinetically inert, the reactivity of rhodium(III) complexes toward biological targets is significantly increased by incorporating appropriate ligands, especially the negatively charged pentamethylcyclopentadienyl ligand (Cp*). 6,7 Recent interest has focused on the investigation of biological functions of promising organometallic rhodium(III) complexes in several biological models.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of binding interactions between three organometallic rhodium(III) complexes with curcuminoid ligands and human serum albumin

Huang

Luo

et al. 2020

J of Molecular Recognition

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Organometallic rhodium(III) complexes with curcuminoid ligands attracted considerable attention in biological‐related fields and the variation of curcuminoid ligands may regulate the biological activity of these organometallic rhodium(III) complexes. To deeply evaluate the biological influences of these complexes, the binding interactions between three rhodium(III) complexes with curcuminoid ligands and human serum albumin (HSA) were comparably investigated by spectroscopic and electrochemical techniques. The results suggested that the intrinsic fluorescence of HSA was quenched by three complexes through static fluorescence quenching mode. Three complexes bonded with Sudlow's site I of HSA to form ground‐state compounds under the binding forces of van der Waals interactions, hydrogen bonds formation, and protonation. Finally, the native conformational structure and the thermal stability of HSA were all changed. Space steric hindrance of complexes took part in the differences of the fluorescence quenching processes, and the chemical polarity of the complexes played a vital role in the variations of the structure and biological activity of HSA. These results illustrated the molecular interactions between protein and organometallic rhodium(III) complexes with curcuminoid ligands, offering new insight about the prospective applications of analogical rhodium(III) complexes in biomedicine areas.

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Section: Introductionmentioning

confidence: 99%

Comparative study of binding interactions between three organometallic rhodium(III) complexes with curcuminoid ligands and human serum albumin

Huang

Luo

et al. 2020

J of Molecular Recognition

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“…Iridium(III) complexes have been investigated for decades because of their stability (Jian et al, 2011;Lee et al, 2009;Tsuboyama et al, 2003), promising luminescent properties (Lin et al, 2011;Lowry et al, 2004;Tamayo et al, 2003) and medicinal applications, especially as anticancer agents (Hearn et al, 2018;Rubio et al, 2020;Xiao et al, 2018). The syntheses of cyclometallated iridium(III) complexes have mainly focused on the 2-phenylpyridine (ppy) ligand and its derivatives.…”

Section: Chemical Contextmentioning

confidence: 99%

Synthesis, crystal structure and Hirshfeld surface analysis of [bis(diphenylphosphanyl)methane-κP]chloridobis[2-(pyridin-2-yl)phenyl-κ²N,C¹]iridium(III)

Klaimanee¹,

Sangwisut²,

Saithong³

et al. 2021

Acta Crystallogr E Cryst Commun

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The title IrIII complex, [Ir(C11H8N)2Cl(C25H22P2)], was synthesized from the substitution reaction between the (ppy)2Ir(μ-Cl)2Ir(ppy)2 (ppy = deprotonated 2-phenylpyridine, C11H8N−) dimer and 1,1-bis(diphenylphosphanyl)methane (dppm, C25H22P2) under an argon gas atmosphere for 20 h. The IrIII atom is coordinated by two C,N-bidentate ppy anions, a unidentate dppm ligand and a chloride anion in a distorted octahedral IrC2N2PCl arrangement. The N donor atoms of the ppy ligands are mutually trans while the C atoms are cis. Intramolecular aromatic π–π stacking between the phenyl rings of ppy and dppm, and C—H...Cl interactions are observed. In the crystal, C—H...Cl and C—H...π contacts link the molecules into a three-dimensional network. A Hirshfeld surface analysis was carried out to further quantify the intermolecular interactions, and indicated that H...H contacts (63.9%) dominate the packing.

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Studies of anticancer activity in vivo and in vitro behaviors of liposomes encapsulated iridium(III) complex

Wen

Zhang

et al. 2021

J Biol Inorg Chem

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Biological activity and photocatalytic properties of a naphthyl-imidazo phenanthroline (HNAIP) ligand and its [Ir(ppy)2(HNAIP)]Cl and [Rh(ppy)2(HNAIP)]Cl complexes

Cited by 11 publications

References 53 publications

Comparative study of binding interactions between three organometallic rhodium(III) complexes with curcuminoid ligands and human serum albumin

Comparative study of binding interactions between three organometallic rhodium(III) complexes with curcuminoid ligands and human serum albumin

Synthesis, crystal structure and Hirshfeld surface analysis of [bis(diphenylphosphanyl)methane-κP]chloridobis[2-(pyridin-2-yl)phenyl-κ²N,C¹]iridium(III)

Studies of anticancer activity in vivo and in vitro behaviors of liposomes encapsulated iridium(III) complex

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Biological activity and photocatalytic properties of a naphthyl-imidazo phenanthroline (HNAIP) ligand and its [Ir(ppy)2(HNAIP)]Cl and [Rh(ppy)2(HNAIP)]Cl complexes

Cited by 11 publications

References 53 publications

Comparative study of binding interactions between three organometallic rhodium(III) complexes with curcuminoid ligands and human serum albumin

Comparative study of binding interactions between three organometallic rhodium(III) complexes with curcuminoid ligands and human serum albumin

Synthesis, crystal structure and Hirshfeld surface analysis of [bis(diphenylphosphanyl)methane-κP]chloridobis[2-(pyridin-2-yl)phenyl-κ2N,C1]iridium(III)

Studies of anticancer activity in vivo and in vitro behaviors of liposomes encapsulated iridium(III) complex

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Synthesis, crystal structure and Hirshfeld surface analysis of [bis(diphenylphosphanyl)methane-κP]chloridobis[2-(pyridin-2-yl)phenyl-κ²N,C¹]iridium(III)