Biological activity and migration of wear particles in the knee joint: an in vivo comparison of six different polyethylene materials

Utzschneider, Sandra; Lorber, Verena; Dedic, Mirza; Paulus, Alexander; Schröder, Christian; Gottschalk, Oliver; Schmitt‐Sody, Marcus; Jansson, Volkmar

doi:10.1007/s10856-014-5176-6

Cited by 12 publications

(12 citation statements)

References 48 publications

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“…Particle suspensions of six PE materials (crosslinked and conventional UHMWPEs with MW = 3 × 10 6 -4 × 10 6 and 5 × 10 6 -6 × 10 6 , respectively) were injected into the knee joints of Balb/c mice. After 1 week, intravital microscopic, histological, and immunohistochemical evaluations were conducted in this study; the data of this study support the use of crosslinked PE in total knee arthroplasty [5]. To enhance creep resistance, high crystallinity appeared to be more critical than a high degree of crosslinking when UHMWPE samples (MW = 5 × 10 6 ) were prepared by gamma irradiation and post-irradiation annealing at a low temperature [6].…”

Section: Introductionmentioning

confidence: 52%

Influence of molecular weight of modified ultrahigh-molecular-weight polyethylene with Cu(II) chelate of bissalicylaldehydeethylenediamine on wear-resistant materials

Liu

Zhang

et al. 2016

Friction

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Reciprocating friction and wear performances of pure ultrahigh-molecular-weight polyethylenes (UHMWPEs) with molecular weights (MWs) of 2, 3, 5, and 9 million and their modified UHMWPEs with 15 wt.% Cu(II) chelate of bissalicylaldehyde-ethylenediamine (add1) against titanium alloy (Ti6Al4V) were investigated under boundary lubrication with 25 vol.% calf serum deionized water solution. Differential scanning calorimetry (DSC) of purchased UHMWPE powders was performed. The enthalpy changed with an increase in MW. UH300 had the lowest temperature of an extrapolated peak and the best peak symmetry in DSC analysis. The friction coefficient curves of molded pure and modified UHMWPEs/Ti6Al4V were compared, and the volume loss by the wear of polymers was measured. 3D topographies of the worn surfaces of polymers and images of the worn surfaces of polymers and titanium alloy against polymers were analyzed by confocal white light microscopy and scanning electron microscopy, respectively. Results showed that the influence of MW of UHMWPE was obvious on the friction and wear characteristics of pure UHMWPEs and 15% add1 UHMWPEs. An MW of 3 million was the best to reduce the friction of rubbing pairs, enhance the wear resistance of pure UHMWPEs and 15% add1-UHMWPEs, and improve the mating properties of Ti6Al4V.

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Section: Introductionmentioning

confidence: 52%

Influence of molecular weight of modified ultrahigh-molecular-weight polyethylene with Cu(II) chelate of bissalicylaldehydeethylenediamine on wear-resistant materials

Liu

Zhang

et al. 2016

Friction

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“…Nevertheless, the primary biological reactions caused by metal products in vivo may be crucial to elucidate the evolution of the pathophysiological events that lead to prosthetic osteolysis. In light of the limitations mentioned above, an established murine model was used in this study, which mimics the initial biological reactions in the synovial-like tissues around prostheses caused by metal particles and ions [35,[37][38][39]. In contrast to various in vitro cell culture studies that focus on one cell type [32,40], the murine model can not only reflect complex cellular and tissue interactions, but can also mimic the dynamic process of joints.…”

Section: Discussionmentioning

confidence: 99%

Biological Reactions to Metal Particles and Ions in the Synovial Layer of Mice

et al. 2020

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Metal particles and ions released from implants not only have a fundamental effect on the longevity of total joint replacements, but can also be disseminated to remote organs. Periprosthetic tissues harvested during revision surgeries mainly reflect end-stage failure but may not adequately reveal initial biological reactions and systemic side effects. Therefore, primary reactions caused by metal particles and ions were investigated in an established murine model. Left knee joints in three groups, each consisting of ten female BALB/c mice, received injections of metal ions (MI), metal particles (MP) and phosphate-buffered saline (PBS) (control). Seven days after the injection, immunohistochemical analyses of the synovial layer were performed with respect to some biological markers including Tumor necrosis factor -α (TNF-α), Interleukin-6 (IL-6), Interleukin-1β (IL-1β), Cluster of Differentiation 45 (CD45), Cluster of Differentiation 68 (CD68) and Cluster of Differentiation 3(CD3). The MP group showed significantly enhanced proinflammatory cytokine expression (TNF-α, IL-6 and IL-1β) compared with the other groups (p < 0.05). Interestingly, CD3, as a marker for T lymphocytes, did not increase in any of the groups. The MI group showed a significantly increased expression of CD45 compared with the control group (p < 0.05). Therefore, during the primary process, metal particles have stronger pro-inflammatory potential than metal ions, and T lymphocytes did not seem to be activated in our murine model. Systemic reactions caused by metal particles and ions were found by observing the untreated right knees.

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“…Metallic or polyethylene particle migration is common after joint replacement and in other clinical settings. [16][17][18][19][20] Silicone has also been reported to migrate. [21][22][23][24] Synthetic ligaments have demonstrated wear particles and fibers in the joint space and lymph nodes at 1 year.…”

Section: Discussionmentioning

confidence: 99%

Suture-Based Debris Behavior in the Draining Lymph Nodes of a Porcine Knee: A Study of Silicone, Polyethylene and Carbon

Barber

Spenciner

Zani

et al. 2019

Arthroscopy, Sports Medicine, and Rehabilitation

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To determine whether debris from a silicone core suture has an observable intra-articular or extra-articular impact or can be shown to migrate into the lymphatic system. Methods: Using a porcine stifle joint model, 2 study groups were created: 1 group used silicone-suture particles created by rupturing hand-tied knots of a nonabsorbable suture with an outer sheath of ultrahigh molecular-weight polyethylene, an inner polyester sheath and a medical-grade silicone/sodium chloride-filled core. The second group used a mixture of 3 vitreous carbon particles sizes. Twelve Yorkshire pigs were randomly assigned to each group. Only 1 type of study particle was used in a single animal to avoid crosscontamination. Half of the study materials were placed by arthrotomy into the joint and, after capsular closure, the remaining half were placed on the joint capsule before skin closure. Six weeks postimplantation, the stifle joints and regional lymph nodes were examined macroscopically and microscopically. The extracapsular and intra-articular tissue and the lymph nodes were examined. Results: Macroscopically, none of the 12 silicone-suture particle group limbs had abnormal macroscopic observations. Of the 12 limbs in the carbon particle group, 8 demonstrated discoloration in the extracapsular, intra-articular and lymph node tissues; 6 limbs demonstrated joint discoloration (extracapsular and intraarticular). The silicone-suture particle group showed lymph node inflammation in 25% of the iliac lymph nodes and 42% of the inguinal lymph nodes but none in the popliteal lymph nodes. In the carbon particle group, 100% of the iliac lymph nodes, 75% of the inguinal lymph nodes and 8% of the popliteal nodes showed inflammation. No silicone-suture debris migration was observed microscopically. Visible carbon particle migration was present in 100% of the iliac lymph nodes and in 50% of the inguinal lymph nodes but in none (0) of the popliteal lymph nodes. The carbon particle group also showed inflammation in these areas. Conclusions: Carbon particles in the porcine knee migrated into the lymph nodes (iliac 100%; inguinal 50%, popliteal 0); gross discoloration was observed in 8 of 12 specimens. Silicone-suture particles could not be found in the lymph nodes, and no macroscopic joint damage was observed. Clinical Relevance: The clinical use of a suture containing a silicone/salt central core is common, and the porcine lymphatic model suggests that this type of suture material does not result in clinically significant silicone particulates.

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Biological activity and migration of wear particles in the knee joint: an in vivo comparison of six different polyethylene materials

Cited by 12 publications

References 48 publications

Influence of molecular weight of modified ultrahigh-molecular-weight polyethylene with Cu(II) chelate of bissalicylaldehydeethylenediamine on wear-resistant materials

Influence of molecular weight of modified ultrahigh-molecular-weight polyethylene with Cu(II) chelate of bissalicylaldehydeethylenediamine on wear-resistant materials

Biological Reactions to Metal Particles and Ions in the Synovial Layer of Mice

Suture-Based Debris Behavior in the Draining Lymph Nodes of a Porcine Knee: A Study of Silicone, Polyethylene and Carbon

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