Biological activities of Zn(II)-S-methyl-cysteine complex as antiradical, inhibitor of acid phosphatase enzyme and in vivo antidepressant effects

Abstract

The antidepressant effect of simple Zn(II) salts has been proved in several animal models of depression. In this study, a coordination metal complex of Zn(II) having a sulfur containing ligand is tested as antidepressant for the first time. Forced swimming test method on male Wistar rats shows a decrease in the immobility and an increase in the swimming behavior after treatment with [Zn(S-Met) 2 ] (S-Met¼S-methyl-L-cysteine) being more effective and remarkable than ZnCl 2 . The thiobarbituric acid and the pyranine consumption (hydroxyl and peroxyl radicals, respectively) methods were applied to evaluate the antioxidant activity of S-Met and [Zn(S-Met) 2 ] showing evidence of attenuation of hydroxyl but not peroxyl radicals activities. UVvis studies on the inhibition of acid phosphatase enzyme (AcP) demonstrated that S-methyl-Lcysteine did not produce any effect but, in contrast, [Zn(S-Met) 2 ] complex behaved as a moderate inhibitor. Finally, bioavailability studies were performed by fluorescence spectroscopy denoting the ability of the albumin to transport the complex.

Evidence of promising biological-pharmacological activities of the sertraline-based copper complex: (SerH2)2[CuCl4]

“…Solutions of FeCl 3 , ascorbate, and H 2 O 2 were made up in deaerated water immediately before use. The extent of deoxyribose degradation by hydroxyl radical was measured with the thiobarbituric acid method [12].…”

“…In recent years we have investigated the antidepressant activity of compounds containing typical antidepressant (sertraline) or antioxidants. They include studies on coordination Zn(II) complexes [10][11][12]. aimed to improve their efficiency.…”