Biological activities of the polysaccharides produced from submerged culture of the edible Basidiomycete Grifola frondosa

Lee, Bum Chun; Bae, Jun Tae; Pyo, Hyeong-Bae; Choe, Taeboo; Kim, Sang Woo; Hwang, Hye Jin; Yun, Jong Won

doi:10.1016/s0141-0229(03)00026-7

Cited by 129 publications

(73 citation statements)

References 24 publications

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“…It is a nutritious food source and is reported to contain bioactive metabolites that exhibit many medicinal effects including anti-tumor, hypocholesterolemic, antioxidant and anti-diabetic activities [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Sensory Evaluation of Fermented Tea with Medicinal Mushrooms

Wei-fang

Guo

et al. 2013

Indian J Microbiol

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In commercial tea production, plenty of tea leaf waste is generated, which may not only exert pollution risk to environment, but also a huge waste of bioactive ingredients in tea. In this study, the 4th to 7th leaves of tea bush were collected and used as substrate for mycelial culture of two renown medicinal mushrooms Grifola frondosa and Tianzhi (new variants of Ganoderma lucidum) to obtain a new type of solid-state fermented tea. Result showed that the polysaccharides of Grifola frondosa and Tianzhi fermented tea were 1.52 and 4.14 %, tea polyphenols were 1.51 and 1.85 %, the free amino acids were 1.52 and 0.94 %, caffeine were 1.16 and 1.70 %, polyphenols/amid acids ratio were 1.0 and 1.98, water extractions were 35.53 and 32.86 %, protein contents were 17.63 and 6.13 mg/g, respectively. The volatile components were mainly composed of alcohols, esters, aldehydes and ketones. The contents of major flavor compositions of fermented tea had changed and their relation tended to be harmonious, and the variety of amino acids significantly increased. Therefore, the sensory flavor and therapeutic qualities of fermented tea were significantly improved.

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Section: Introductionmentioning

confidence: 99%

Chemical Composition and Sensory Evaluation of Fermented Tea with Medicinal Mushrooms

Wei-fang

Guo

et al. 2013

Indian J Microbiol

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“…[41] Incorporation of linear PEG chains to matrices of hydrogel increases the degree of adhesiveness to the mucous membrane because of the interpenetration of chain that occurs at the mucus/hydrogel interface has also been reported. [42] Sulfated polysaccharide Sulfated derivatives of polysaccharides have been taken into account, and high focus has been given on both its biological and chemical properties from the past decade. [43] Biological activities have been studied for the sulfated polysaccharides to look for its anticoagulant, antioxidant, and antithrombotic activities.…”

Section: Poloxamersmentioning

confidence: 99%

Untitled

Verma¹

2018

IJGP

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Considering the compliance of patients and ease of administration, the oral cavity is profoundly chosen to deliver drugs. This article focuses on mucoadhesive buccal drug delivery system providing sustained release of the drug. The drug of choice for buccal delivery is those which undergoes high first-pass metabolism or undergo acid degradation. This review article aims to focus on various aspects of buccal films, factors affecting mucoadhesion and its evaluating parameters. Different theories involved in mucoadhesion process and along with the polymers that are involved in developing different categories of films have been focused. Factors influencing the polymers involved flexibility, molecular weight, charge, etc., are also considered in this review. Most commonly used polymers in the development of mucoadhesive films are lectins, starch, pectins, and cellulose derivatives, etc. Several agents such as penetration enhancers and mucoadhesive agents are employed to develop an ideal film. These dosage forms are formulated using two processes, namely film casting method and hot-melt extrusion method. The developed films are evaluated based on multiple parameters such as surface pH, flatness, tensile strength, and peel strength. This review gives an overall view of different polymers that are used to develop the mucoadhesive films and compare their degree of mucoadhesion along with their parametric tests to evaluate the developed films.

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“…In recent years, submerged culture, a microbial bioprocess commonly used for producing various primary and secondary metabolites, has been utilized to cultivate higher basidiomycetes mushrooms for the production of biomass and various bioactive substances (Lee et al, 2003;Shih et al, 2006). The significant advantages of submerged culture over solid-state fermentation include shorter production period, lower production cost and easy regulation of environmental parameters (Bae et al, 2000;Chang et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Sonoporation of Ganoderma lucidum Mycelium for High Biomass and Exopolysaccharide Productivity in Submerged Culture

Liu¹,

Zhang²,

Kuang³

et al. 2016

IJAB

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Ganoderma lucidum, known as Lingzhi in China and Reishi in Japan, is a famous medicinal mushroom that is commonly produced by solid-state fermentation. Recently, submerged culture has been considered as a promising alternative for production of G. lucidum. Herein, to provide a theoretical base for preparation of a homogenous inoculum for G. lucidum submerged culture we investigated the effect of sonoporation on G. lucidum mycelium. Submerged culture was also evaluated using the sonoporated mycelium. Microscopic investigation indicated that the mycelial pellets (0.55 g, dry weight) contained in 60 mL solution were almost completely disappeared within 20 s by sonoporation (20 kHz and 125 w). The homogenate obtained after sonoporation had a 3.75×106 cfu/mL cell concentration. The sonoporation caused rapid leakage of intracellular protein that increased linearly with time. The metabolic activity of the cells decreased rapidly after sonoporation. Sonoporation also negatively affected laccase activity. When the homogenate was used at 4.76% (v/v) inoculum level, the cultures produced biomass and exopolysaccharide of 15.75 and 0.54 g/L, respectively; these values were 129.26 and 45.95% higher than that of the control culture using a pellet-type inoculum without sonoporation. Optimal inoculum size was 5.88-6.97% (v/v). We conclude that sonoporation is an effective method for homogenization of G. lucidum mycelium, and sonoporated mycelium can improve productivity significantly in G. lucidum submerged culture and requires lower levels of starting inoculum.

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Biological activities of the polysaccharides produced from submerged culture of the edible Basidiomycete Grifola frondosa

Cited by 129 publications

References 24 publications

Chemical Composition and Sensory Evaluation of Fermented Tea with Medicinal Mushrooms

Chemical Composition and Sensory Evaluation of Fermented Tea with Medicinal Mushrooms

Untitled

Sonoporation of Ganoderma lucidum Mycelium for High Biomass and Exopolysaccharide Productivity in Submerged Culture

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