Biological activities of South African Salvia species and isolated compounds

Kamatou, Guy; Zy, R. L. van; Vuuren, S.F. Van; Davids, Hajierah; Viljoen, A; Seaman, T.; Heerden, Fanie R. van

doi:10.1055/s-2007-986930

Cited by 2 publications

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“…The genus Salvia includes more than 900 species and is now being intensively studied in view of the antioxidant, antibacterial and antifungal properties that many exudation products, mainly containing ursolic and oleanolic acids, have been shown to posses [22][23][24][25].…”

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confidence: 99%

Effects of demethylfruticuline A and fruticuline A from Salvia corrugata Vahl. on biofilm production in vitro by multiresistant strains of Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis

Schito

Piatti

Stauder

et al. 2011

International Journal of Antimicrobial Agents

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In this study, demethylfruticuline A (dfA) and fruticuline A (fA), two quinones representing the mayor diterpenoid components of the exudate produced by the aerial parts of Salvia corrugata, were assessed for their ability to modify surface characteristics, such as hydrophobicity, and to inhibit synthesis of biofilm in vitro by multiresistant Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis. Five strains of S. aureus (three meticillin-resistant and two meticillinsusceptible), five strains of S. epidermidis (four meticillin-resistant and one meticillinsusceptible) and eight vancomycin-resistant E. faecalis, all recently isolated from clinical specimens and capable of slime production, were studied. fA decrease by at least two-fold the hydrophobic properties of the S. aureus cell membrane but did not affect S. epidermidis or E. faecalis. Biofilm formation on polystyrene plates was quantified spectrophotometrically by established methodologies. Inhibition of biofilm formation was also confirmed by the Congo red agar plate assay. dfA and fA were more effective against S. aureus strains (>70% effect at subinhibitory concentrations) than against S. epidermidis in inhibiting slime synthesis. Against E. faecalis, dfA at subinhibitory concentration induced an inhibition of biofilm production of ca. 60%; fA was less active and more strain-dependent. Moreover, the two compounds were shown to posses chelating activity on divalent and trivalent metal cations.Interactions of fA and dfA with bacteria could be very complex, possibly being species-specific, and could depend not only on inhibition of exopolysaccharide synthesis but also on their chelating activity and on changes in the microorganism's surface, including cell hydrophobicity.

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confidence: 99%

Effects of demethylfruticuline A and fruticuline A from Salvia corrugata Vahl. on biofilm production in vitro by multiresistant strains of Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis

Schito

Piatti

Stauder

et al. 2011

International Journal of Antimicrobial Agents

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“…S. Africana-lutea has been reported to have phenolic compounds, which can be complex with bacterial cell walls and disrupt microbial membranes by inhibiting matrix formation. 76 Both extracts showed the presence of flavonoids, which have been reported to bind to and inhibit matrix formation. 70 Since S. pruriens is from the same family as H. benghalensis, there might be similarities in their phytochemical composition.…”

Section: Therapeutics To Combat Biofilm Forming Mycobacteria Recalcit...mentioning

confidence: 97%

Novel Therapeutics: A Nemesis for Biofilm-forming Mycobacterium spp.

Pandey,

Ahmad,

Singh

et al. 2023

J. Pure Appl. Microbiol.

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Tuberculosis (TB) is a contagious disease that is a significant cause of illness worldwide and has been declared one of the top ten causes of mortality across the world. It is well known that bacteria within biofilms exhibit much higher drug resistance than individual cells. Biofilms constitute a significant threat in the clinical environment by acting as reservoirs of multidrug-resistant bacteria. Thus, the formation of biofilms has been postulated to further aid in drug insensitivity and bacterial persistence within host tissues. The rapid increase in drug resistance in Mycobacteria poses a significant challenge to TB eradication and needs to be addressed soon. In this review, we have attempted to frame a general overview of mycobacterial pathogenesis, the role of biofilm formation in enhancing its shelf life, and some natural compounds and nanoparticles as emerging novel therapeutics reported to inhibit biofilm formation in mycobacteria. Therefore, we present some recent advances which might have potential applications in new treatment regimens for Tuberculosis.

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Biological activities of South African Salvia species and isolated compounds

Cited by 2 publications

References 0 publications

Effects of demethylfruticuline A and fruticuline A from Salvia corrugata Vahl. on biofilm production in vitro by multiresistant strains of Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis

Effects of demethylfruticuline A and fruticuline A from Salvia corrugata Vahl. on biofilm production in vitro by multiresistant strains of Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis

Novel Therapeutics: A Nemesis for Biofilm-forming Mycobacterium spp.

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