Biological Activities of Snowdrop (Galanthus spp., Family Amaryllidaceae)

Kong, Chee Kei; Low, Liang Ee; Siew, Wei Sheng; Yap, Wei Hsum; Khaw, Kooi Yeong; Ming, Long Chiau; Mocan, Andrei; Goh, Bey Hing; Goh, Hui Poh

doi:10.3389/fphar.2020.552453

Cited by 13 publications

(8 citation statements)

References 60 publications

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“…Antioxidants play an important role in the promotion of cardiovascular health since oxidative stress that inflicts the myocardium can be associated with the incidence of atherosclerosis, which increases the risk of coronary artery disease [ 100 , 101 ]. C. sativum has been demonstrated in many studies to possess a pronounced antioxidant activity, and this is mainly due to the activity of polyphenols, vitamins, and sterol constituents of coriander [ 78 , 89 , 90 ].…”

Section: Discussionmentioning

confidence: 99%

Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits

et al. 2021

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Coriandrum sativum (C. sativum), belonging to the Apiaceae (Umbelliferae) family, is widely recognized for its uses in culinary and traditional medicine. C. sativum contains various phytochemicals such as polyphenols, vitamins, and many phytosterols, which account for its properties including anticancer, anti-inflammatory, antidiabetic, and analgesic effects. The cardiovascular benefits of C. sativum have not been summarized before, hence this review aims to further evaluate and discuss its effectiveness in cardiovascular diseases, according to the recent literature. An electronic search for literature was carried out using the following databases: PubMed, Scopus, Google Scholar, preprint platforms, and the Cochrane Database of Systematic Reviews. Articles were gathered from the inception of the database until August 2021. Moreover, the traditional uses and phytochemistry of coriander were surveyed in the original resources and summarized. As a result, most of the studies that cover cardiovascular benefits and fulfilled the eligibility criteria were in vivo, while only a few were in vitro and clinical studies. In conclusion, C. sativum can be deemed a functional food due to its wide range of cardiovascular benefits such as antihypertensive, anti-atherogenic, antiarrhythmic, hypolipidemic as well as cardioprotective effects.

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Section: Discussionmentioning

confidence: 99%

Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits

et al. 2021

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“…It exhibits tenfold greater affinity for brain AChE than for the peripheral one although it is a weak inhibitor of AChE. Galantamine is a natural alkaloid isolated from the flowers of Galanthus nivalis and some other varieties of the family Amaryllidaceae (Kong et al., 2020). It is a selective and reversible inhibitor of AChE.…”

Section: Current Treatment For Alzheimer's Disease (Ad)mentioning

confidence: 99%

A recent update on huprine and its hybrids as a potential multifunctional agent for the treatment of Alzheimer's disease

Singh,

Kumar

2024

Chem Biol Drug Des

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Alzheimer's disease (AD) is a common age‐related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions. Although there is currently no successful pharmacotherapy for AD, researchers are continuously exploring the various pathogenesis of AD to develop potential therapeutic drugs. Of the multiple hypotheses for AD, the cholinergic and amyloid‐β (Aβ) hypothesis are the main targeting hypothesis for AD. Some researchers proposed that the symptoms involved in AD (loss of memory, cognitive impairment, and amnesia) are the main event linked to the cholinergic neurotransmitter (acetylcholine). Therefore, the development of AChE inhibitors to increase the level of ACh in the synaptic cleft can improve learning and memory in AD patients. Huprine X is a synthetic ChE inhibitor developed by the hybridization of Huperzine A and the synthetic drug tacrine. This review focuses on the last 10 year's literature search on huprine and its analogues for the treatment of AD. We expect that this review can be helpful for medicinal chemists, and neuro‐chemists to provide new ideas for the development of new drugs therapy for AD.

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“…Galantamine is an alkaloid that has been isolated from the bulbs and flowers of Galanthus nivalis, Galanthus caucasicus, and other genera of the Amaryllidaceae family (Kong et al, 2020). It is a competitive and reversible inhibitor of AChE.…”

Section: Current Therapeutic Options For Admentioning

confidence: 99%

“…Novel and potent analogs of benzopyrano[4,3‐b]pyrrole carbamates were developed as derivatives of rivastigmine to improve their potency. Galantamine is an alkaloid that has been isolated from the bulbs and flowers of Galanthus nivalis , Galanthus caucasicus , and other genera of the Amaryllidaceae family (Kong et al, 2020). It is a competitive and reversible inhibitor of AChE.…”

Section: Current Therapeutic Options For Admentioning

confidence: 99%

Tryptamine: A privileged scaffold for the management of Alzheimer's disease

Singh,

Kumar

2023

Drug Development Research

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Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disease associated with aging. It is characterized by the progressive loss of memory and other cognitive functions. Although the exact etiology of AD is not well explored, several factors, such as the deposition of amyloid‐β (Aβ) plaques, hyperphosphorylation of tau protein, presence of low levels of acetylcholine, and generation of oxidative stress, are key mediators in the progression of AD. Currently, the clinical treatment options for AD are limited and are based on cholinesterase (ChE) inhibitors (e.g., donepezil, rivastigmine, and galantamine), N‐methyl‐d‐aspartic acid receptor antagonists (e.g., memantine), and the recently approved Aβ modulator (e.g., aducanumab). Tryptamine (2‐(1H‐indol‐3‐yl)ethan‐1‐amine) is a small molecule that contains an indole nucleus and an ethylamine side chain. It is also the active metabolite of tryptophan. It possesses a wide range of biological activities related to neurodegenerative disorders, such as ChE inhibition, Aβ aggregation inhibition, antioxidant effects, monoamine‐oxidase inhibition, and neuroprotection. Several tryptamine‐based hybrid analogs are currently being investigated as multifunctional agents for the development of novel hybrids for AD treatment. Thus, this review article aims to provide in‐depth insights into the research progress and strategies for designing multifunctional agents used in Alzheimer's therapy.

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Biological Activities of Snowdrop (Galanthus spp., Family Amaryllidaceae)

Cited by 13 publications

References 60 publications

Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits

Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits

A recent update on huprine and its hybrids as a potential multifunctional agent for the treatment of Alzheimer's disease

Tryptamine: A privileged scaffold for the management of Alzheimer's disease

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