Biological Activities of Quinoline Derivatives

Abstract

Quinoline and its fused heterocyclic derivatives tested with diverse pharmacological activity functional groups constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. The present review provides an in depth view of work done so far on quinolines and its biological activities covering anticancer, antimycobacterial, antimicrobial, anticonvulsant, antiinflamatory and cardiovascular activities.

Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues

“…Quinoline and their derivatives play important roles in the synthesis of natural products and as therapeutic agents, and constitute an important class of compounds for new drug development. They have been synthesized by many researchers as model compounds 14 and found to exhibit different pharmacological activities covering anti-cancer, anti-mycobacterial, anti-microbial, anti-convulsant, anti-inflammatory, and cardiovascular activities [15][16][17][18][19] .…”

In-Vitro Antibacterial / Antifungal Screening of 2-Chloroquinoline Scaffold Derivatives

“…The 1,3,4-oxadiazole derivatives (7)(8)(9)(10) were synthesized by cyclisation of hydrazones (3-6) of isonicotinic acid hydrazide (INH) or benzoic acid hydrazide with intermediate 1 and 2 using chloramine-T as catalyst in refluxing ethanol. The 2-chloro-3-formylquinoline and 2-chloro-3-formyl-6-methylquinoline (1, 2) were further reduced to alcohol (11,12) using solid NaBH 4 in methanol and subsequent reaction of 11 or 12 with benzoyl or p-methyl benzoyl chloride in pyridine affords various benzoate derivatives (13)(14)(15)(16). The chlorination of compounds (11,12) with SOCl 2 in dry benzene afforded intermediates 3-(chloromethyl)-2-chloroquinoline (17,18) and their successive nucleophilic substitution reaction with sulphanilamide or p-aminophenol in absolute ethanol in the presence of organic base triethylamine (TEA) gave 2-chloroquinolinyl amines (19)(20)(21)(22).…”

Antibacterial Screening of some Heterocyclic Compounds Containing Quinoline Nucleus

“…These derivatives are also used for the preparation of nano-and meso structures having enhanced electronic and photonic properties [9,10] and are known to have applications as pharmaceuticals, agrochemicals and synthetic building blocks [11]. Quinolines have been found to possess antimalarial, anti-bacterial, antifungal, antihelmintic, cardiotonic, anticonvulsant, anti-inflammatory, and analgesic activity [12][13][14][15][16][17][18].…”