Biological activities of meroterpenoids isolated from different sources

Abstract

Meroterpenoids are natural products synthesized by unicellular organisms such as bacteria and multicellular organisms such as fungi, plants, and animals, including those of marine origin. Structurally, these compounds exhibit a wide diversity depending upon the origin and the biosynthetic pathway they emerge from. This diversity in structural features imparts a wide spectrum of biological activity to meroterpenoids. Based on the biosynthetic pathway of origin, these compounds are either polyketide-terpenoids or non-polyketide terpenoids. The recent surge of interest in meroterpenoids has led to a systematic screening of these compounds for many biological actions. Different meroterpenoids have been recorded for a broad range of operations, such as anti-cholinesterase, COX-2 inhibitory, anti-leishmanial, anti-diabetic, anti-oxidative, anti-inflammatory, anti-neoplastic, anti-bacterial, antimalarial, anti-viral, anti-obesity, and insecticidal activity. Meroterpenoids also possess inhibitory activity against the expression of nitric oxide, TNF- α, and other inflammatory mediators. These compounds also show renal protective, cardioprotective, and neuroprotective activities. The present review includes literature from 1999 to date and discusses 590 biologically active meroterpenoids, of which 231 are from fungal sources, 212 are from various species of plants, and 147 are from marine sources such as algae and sponges.

The Role of Sargahydroquinoic Acid and Sargachromenol in the Anti-Inflammatory Effect of Sargassum yezoense

“…Synthesized by diverse organisms, including algae, meroterpenoids exhibit structural diversity based on their origin and biosynthesis. This diversity underpins their broad spectrum of biological activities, encompassing anti-cholinesterase, anti-diabetic, antioxidative, anti-inflammatory, and antineoplastic properties, alongside renal, cardioprotective, and neuroprotective effects [ 7 ]. Sargassum species are also rich sources of meroterpenoid compounds, including sargahydroquinoic acid (SHQA), sargachromenol (SCM), and sargaquinoic acid (SQA) [ 8 ].…”

Anticancer Meroterpenoids from Centrapalus pauciflorus leaves: Chromone- and 2,4-Chromadione-Monoterpene Derivatives

“…Chromane/chromene meroterpenoids have displayed cytotoxic activity against different tumor cell lines, as well as antioxidant and antimicrobial activities. Furthermore, they have been reported to inhibit various enzymes, including protein tyrosine phosphatase 1B (PTP1B), butyrylcholinesterase (BChE), β-site amyloid precursor protein cleavage enzyme 1 (BACE1), and protein farnesyl transferase (PFTase). , …”

“…Furthermore, they have been reported to inhibit various enzymes, including protein tyrosine phosphatase 1B (PTP1B), butyrylcholinesterase (BChE), β-site amyloid precursor protein cleavage enzyme 1 (BACE1), and protein farnesyl transferase (PFTase). 1 , 18 …”

Anti-inflammatory, remorin-like protein from green marine Macroalga Caulerpa sertularioides (S.G.Gmel.) M.Howe

“…Thus, PGE 2 and its mediated activities are the specific target for pain relief, and anti-inflammation treatments [ 9 ]. Fuloria et al have discussed about 590 meroterpenoids (polyketide or non-polyketide terpenoids) and their biological activities (anticholinesterase, COX-2 inhibition, antioxidative, and antibacterial), in which 39%, 36%, and 25% were from fungi, plants and marine sources including sponges and algae [ 10 ].…”