Biological activities of lignoids from Amazon Myristicaceae species: Virola michelii, V. mollissima, V. pavonis and Iryanthera juruensis

Abstract

O trabalho consiste na re-investigação dos frutos de Iryanthera juruensis e Virola pavonis e das folhas de V. michelii, bem como no estudo dos frutos de V. mollissima. A partir de I. juruensis foram isoladas uma neolignana ariltetralínica (1) e uma neolignana tetraidrofurânica (2), enquanto que de Virola pavonis foram isoladas neolignanas benzofurânicas (6-9), tetraidrofurânicas (2, 11-13, 17), bifenílica (10), diastereoisômeros de uma hidróxi-neolignana 8.O.4'(14-15) e outras. V. mollissima acumula a neolignana ariltetralônica 4 ou o seu derivado seco (5). As folhas de V. michelii apresentaram a ocorrência de lignanas furofurânicas (18)(19). Os lignóides 1 e 2 obtidos dos arilos de I. juruensis apresentaram atividade leishmanicida contra a forma promastigota de Leishmania amazonensis.This work revisits the fruits of Iryanthera juruensis and Virola pavonis and the leaves from V. michelii, as well as describing a study of the fruits of V. mollissima. In I. juruensis aryltetraline neolignan (1) and tetrahydrofuran neolignan (2), were found while from V. pavonis neolignans of benzofuran type (6-9), the tetrahydrofuran type (2, 11-13, 17) and the biphenyl type (10), in addition to diastereoisomers of the 8.O.4'-oxyneolignan type (14 and 15) and others were isolated. The V. mollissima accumulates the aryltetralone neolignan 4 and its seco derivative (5). The lignoids 1 and 2 obtained from I. juruensis arils possess antileishmanial activity against the promastigote form of Leishmania amazonensis.

Chakyunglupulins A and B, two novel 4,8,8-trimethylcyclooct-2-enone derivatives from Barleria lupulina

“…The known compounds were identified as buddlenol C ( 3 ), 17 medioresinol ( 4 ), 18 (+)-eudesmin ( 5 ), 19 (−)-(7 R ,7′ R ,7″ R ,8 S ,8′ S ,8″ S )-4′,4″-dihydroxy-3,3′,3″,5-tetramethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineolignan-7″,9″-diol ( 6 ), 20 (−)- (7 R ,7′ R ,7″ R ,8 S ,8′ S ,8″ S )-4′,4″-dihydroxy-3,3′,3″,5′,5″-hexamethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineolignan-7″,9″-diol ( 7 ), 20 and (+)-syringaresinol ( 8 ) 21 by comparison of their physical and spectroscopic data with those previously reported in the literature.…”

Conformational analysis of phloroglucinols from hypericum Brasiliense by using x-ray diffraction and molecular modeling

“…The conformations on Figure 2 reveals that this type of calculation should be extremely useful in predicting conformational preferences of similar structures since the geometries obtained experimentally by X-ray diffraction and theoretically by molecular modeling are very close (RMS = 0.016 Å for compound (1) and 0.014 Å for compounds (2) and (3)). It is important to notice that although the structure in solution is the most important one when we are studying biological activity, in the case focused here, changes in conformation will probably be minor due to the several hydrogen bonds.…”

“…However, just 8% of the Brazilian flora has been already studied in the search for new bioactive substances. 1,2 In the last decades several antibacterial compounds are being less effective in the treatment of infectious diseases due to multi-resistant bacteria. 3 In this context medicinal plants are extremely important in the search of new molecules as therapeutic alternatives.…”

Ethnobotanical Research at the Kutukú Scientific Station, Morona-Santiago, Ecuador

“…Outside Ecuador, this plant was tested in Brazil for the treatment of leishmaniosis [26], while the antifungal activity of the extracts from the leaves was studied in detail by Zacchino et al [27]. The leaves of Siparuna harlingii S. S. Renner & Hausner are used by the local inhabitants as remedies for headache and cough and as an anti-inflammatory.…”