Biological Activities of IgA

Russell, Michael W.; Kilian, Mogens; Mantis, Nicholas J.; Corthésy, Blaise

doi:10.1016/b978-0-12-415847-4.00021-5

Cited by 47 publications

(43 citation statements)

References 306 publications

(237 reference statements)

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“…The essential protective role of mucosal antibodies within the intestinal lumen was convincingly demonstrated in a unique model of colostrum-deprived newborn piglets, where survival is fully dependent on the ingestion of antibodies irrespective of their isotype (120). More recently, numerous experiments performed in mice either carrying 'piggy-back' hybridoma tumors that secrete monoclonal antibodies specific for various microbial antigens, or passively administered monoclonal antibodies of such specificity, clearly demonstrated the protective role when such animals were infected with corresponding pathogens by various mucosal routes (21). Some of the key roles played by IgA in protection of mucosal surfaces are depicted in Fig.…”

Section: Functions Of Mucosal Antibodiesmentioning

confidence: 96%

“…Consequently, passive systemic infusion of preformed pIgA of desired specificity would have minimal impact on the protection of the vast surface area of mucosal membranes. This effect, however, is not true in all species: in rats, mice and rabbits, due to hepatocyte expression of pIgR, pIgA is selectively transported by the hepatobiliary pathway into bile and ultimately into intestinal secretions (15) and provides excellent protection against intestinal pathogens (21). With the possible exception of female genital tract secretions that contain a significant proportion of IgG produced locally by abundant IgG-producing cells (22), the IgG present or found in external secretions originates predominantly from the circulation.…”

Section: Biosynthesis and Origin Of Mucosal Igsmentioning

confidence: 99%

“…Mucosal antibodies effectively diminish absorption of soluble or particulate antigens by mucosal surfaces. Thus, animals with mucosal antibodies specific for ingested food proteins or in vitro haptenated proteins exhibit greatly reduced absorption of such proteins when compared to non-immunized animals (21,121). Furthermore, IgA-deficient individuals absorb food antigens in greater quantities than healthy controls (13).…”

Section: Direct Functionsmentioning

confidence: 99%

“…Antigen-specific mucosal antibodies bound to commensal as well as pathogenic microorganisms effectively inhibit their adherence to epithelial cells that display corresponding receptors on their surfaces (21,124,125). S-IgA confers microbes with a negatively charged and hydrophilic 'coat' that repels their attachment to mucosal surfaces.…”

Section: Direct Functionsmentioning

confidence: 99%

See 3 more Smart Citations

Mucosal Immunoglobulins

Woof

2015

Mucosal Immunology

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Section: Functions Of Mucosal Antibodiesmentioning

confidence: 96%

Section: Biosynthesis and Origin Of Mucosal Igsmentioning

confidence: 99%

Section: Direct Functionsmentioning

confidence: 99%

Section: Direct Functionsmentioning

confidence: 99%

See 2 more Smart Citations

Mucosal Immunoglobulins

Woof

2015

Mucosal Immunology

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“…Secretory IgA is the key immunoglobulin in respiratory and gastrointestinal tracts, which is the actual interface between the environment and the human body [11] . Low levels of IgA in saliva have been reported as a risk factor for upper respiratory infection [12] . Moreover, recurrent sinopulmonary infections of the respiratory system are the most common findings in individuals with IgA deficiency [13][14][15] .…”

Section: Resultsmentioning

confidence: 99%

Salivary IgA Correlate with Recurrent Respiratory Infections and Hyperreactivity in Children with Autism

Furland

Sindelar²

2016

International Journal of Neurology Research

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AIM: Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted interests and behaviors. Accumulating evidence suggests that dysregulation of the immune system may be involved in the pathophysiology of ASD. The aim of the study was to assess if the severity of clinical and behavioral parameters of autistic children was associated with low levels of secretory IgA (sIgA) in saliva. We hypothesized that a decreased immune response in children with autism would decrease the levels of sIgA, as is the predominant antibody isotype in saliva and a marker of mucosal immunity. MATERIALS AND METHODS: Saliva samples were obtained from 3-10 year-old children with ASD and age-matched typically developing Caucasian children from Patagonia region, Argentina. RESULTS AND CONCLUSIONS: Autistic children with reduced levels of salivary IgA had a higher incidence of upper respiratory diseases compared to the controls. The reduction in sIgA levels also correlated inversely with the severity of the behavioral disorders. The patients with the most severe impairment in autism-related behaviors had the lowest levels of sIgA in the cohort studied. These findings suggest that sIgA could be an early indicator and possibly a biomarker of the dysregulation of the immune system in some children with autism. The characterization of immunological parameters in ASD has important implications for detection of a subset of individuals with ASD, and should be considered when designing therapeutic strategies to treat core symptoms and behavioral impairments of ASD.

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What you need to know about IgA deficiency: A case study

Mertin

Thomson

2014

Journal of the American Association of Nurse Practitioners

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Purpose To provide nurse practitioners (NPs) with an overview of the physiology, pathophysiology, associated diseases clinical implications for blood transfusions for patients with immunoglobulin A deficiency (IgAD). Data sources A review of the scientific literature was performed on IgAD using PubMed, Medline, and CINAHL. The case study of a patient with IgAD going for cardiac surgery is used to integrate this knowledge into clinical practice. Conclusions IgAD is being identified in asymptomatic people through screening for numerous conditions. NPs receiving results on their patients may not fully comprehend the significance of IgAD. Implications for practice Knowledge of the underlying physiology and pathophysiology of IgAD enables the NP to obtain an accurate and comprehensive patient assessment, establish differential diagnoses, and manage issues related to potential associated conditions as well as potential blood transfusion risks.

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Biological Activities of IgA

Cited by 47 publications

References 306 publications

Mucosal Immunoglobulins

Mucosal Immunoglobulins

Salivary IgA Correlate with Recurrent Respiratory Infections and Hyperreactivity in Children with Autism

What you need to know about IgA deficiency: A case study

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