Biological activities of Chromolaena odorata: A mechanistic review

Olawale, Femi; Olofinsan, Kolawole; Iwaloye, Opeyemi

doi:10.1016/j.sajb.2021.09.001

Cited by 24 publications

(15 citation statements)

References 102 publications

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“…Pharmacological investigations showed that C. odorata contains secondary metabolites in many chemical classes, such as flavonoids, phenolic acids, saponins, terpenoids and tannins. Some of those compounds were related to the pharmacological activity such as analgesic, antipyretic, anti-inflammatory, anti-diabetic, anticancer, and antioxidant activity [ 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 ]. Although most of those identified compounds have not yet been related to the invasiveness of the plant species, some of them may be involved in the allelopathy and defense functions against herbivores, nematodes, and fungal pathogens.…”

Section: Diversity Of the Secondary Metabolites In C Odoratamentioning

confidence: 99%

Evolution of the Secondary Metabolites in Invasive Plant Species Chromolaena odorata for the Defense and Allelopathic Functions

Kato‐Noguchi

Kato

2023

Plants

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Chromolaena odorata (L.) R.M. King & H. Robinson is native to tropical America, and has naturalized in many other countries in tropical Asia, Austria, and West Africa. The species often forms dense thickets and reduces the native species diversity and population in the invasive ranges. The species is also considered as a noxious weed in agriculture fields, and listed in the 100 of the world’s worst invasive alien species. The characteristics of its life-history such as the seed production rate, growth pattern, and adaptative ability to the environmental conditions may contribute to the invasiveness of the species. Possible evidence of the defense capacity against the natural enemy, and the allelopathic potential against the competitive plant species for C. odorata has been accumulated in the literature over three decades. The extracts, residues, and/or rhizosphere soil of C. odorata increased the mortality of various insects and parasitic nematodes, and decreased their population. The extracts, residues, and/or rhizosphere soil of C. odorata also inhibited the germination and growth of several plant species including the indigenous plant species in the invasive ranges of C. odorata. Toxic substances, pyrrolizidine alkaloids were found in the leaves and flowers of C. odorata. These pyrrolizidine alkaloids may work as the defense agents against the natural enemies. Several potential allelochemicals such as flavonoids, phenolic acids, and terpenoids were also found in the plant extracts of C. odorata. Some of these compounds may work as allelopathic agents of C. odorata and inhibit the germination and growth of the competitive plant species. These characteristics of C. odorata for the defense function against their natural enemies such as insects and parasitic nematodes, and allelopathic potential against the competitive native plant species may contribute to the invasiveness and naturalization of C. odorata in the new habitats as invasive plant species. However, it is necessary to determine the concentration of these allelochemicals in the neighboring environment of C. odorata such as the rhizosphere soil since allelochemicals are able to work only when they are released into the neighboring environment. It is the first review article focusing on the defense function and allelopathy of C. odorata.

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Section: Diversity Of the Secondary Metabolites In C Odoratamentioning

confidence: 99%

Evolution of the Secondary Metabolites in Invasive Plant Species Chromolaena odorata for the Defense and Allelopathic Functions

Kato‐Noguchi

Kato

2023

Plants

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“…By degrading heme, HO-1 prevents oxidative damage by heme protein. Besides HO-1, Nrf2 activation have also been linked to the increased expression of other and drug-metabolizing enzymes such as NAD(P)H:quinone acceptor oxidoreductase (NQO) and antioxidant enzymes, including catalase (CAT), SOD, GPX and GST via the Nrf2/ARE pathway ( 81 ).…”

Section: Recent Research Advances Of Capsaicin On Human Cancermentioning

confidence: 99%

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

et al. 2022

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Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in the genus Capsicum. Due to its numerous biological effects, there has been extensive and increasing research interest in capsaicin, resulting in increased scientific publications in recent years. Therefore, an in-depth bibliometric analysis of published literature on capsaicin from 2001 to 2021 was performed to assess the global research status, thematic and emerging areas, and potential insights into future research. Furthermore, recent research advances of capsaicin and its combination therapy on human cancer as well as their potential mechanisms of action were described. In the last two decades, research outputs on capsaicin have increased by an estimated 18% per year and were dominated by research articles at 93% of the 3753 assessed literature. In addition, anti-cancer/pharmacokinetics, cytotoxicity, in vivo neurological and pain research studies were the keyword clusters generated and designated as thematic domains for capsaicin research. It was evident that the United States, China, and Japan accounted for about 42% of 3753 publications that met the inclusion criteria. Also, visibly dominant collaboration nodes and networks with most of the other identified countries were established. Assessment of the eligible literature revealed that the potential of capsaicin for mitigating cancer mainly entailed its chemo-preventive effects, which were often linked to its ability to exert multi-biological effects such as anti-mutagenic, antioxidant and anti-inflammatory activities. However, clinical studies were limited, which may be related to some of the inherent challenges associated with capsaicin in the limited clinical trials. This review presents a novel approach to visualizing information about capsaicin research and a comprehensive perspective on the therapeutic significance and applications of capsaicin in the treatment of human cancer.

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“…C. odorata is known by other names such as baby tea, bitter bush, Armstrong's weed, butterfly weed, devil weed, king weed, Christmas bush, Siam weed, eupatorium, paraffin weed and turpentine weed [11]. It contains bioactive compounds such as steroids, flavonoids, alkaloids, tannins and saponins, which can act singly or synergistically to exert different biological effects [12]. In sub-Saharan Africa and it is use for the treatment of different ailments and disease conditions such as diabetes, inflammation, wounds and fever [12].…”

Section: Acquisition Of Mice Parasites and Mice Inoculationmentioning

confidence: 99%

“…It contains bioactive compounds such as steroids, flavonoids, alkaloids, tannins and saponins, which can act singly or synergistically to exert different biological effects [12]. In sub-Saharan Africa and it is use for the treatment of different ailments and disease conditions such as diabetes, inflammation, wounds and fever [12]. In Benin and Ghana, infusion from fresh leaves of C. odorata is used to treat malaria [13].…”

Section: Acquisition Of Mice Parasites and Mice Inoculationmentioning

confidence: 99%

Toxicity and Antiplasmodial Assessments of Chromolaena odorata Leaf Extract on Plasmodium berghei-Infected Mice

Ogechi¹,

Kinsley²,

Adikwu³

2022

J Infect Dis Epidemiol

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Introduction:This study assessed the toxicity and antiplasmodial profile of the ethanolic leaf extract of Chromolaena odorata on Plasmodium berghei-infected mice. Methods:The extract was screen qualitatively and quantitatively for phytochemical constituents. Adult Swiss albino mice (20-23 g) of n = 5/group were inoculated with Plasmodium berghei intraperitoneally and were orally treated with the extract (250, 500 and 1000 mg/kg) and CQ (10 mg/kg) (Standard) daily, respectively. In the subacute toxicity study, mice (n = 5/group) were treated with the extract (250, 500 and 1000 mg/kg) daily for 28 days, respectively. After treatments, blood samples were collected and examined for percentage parasitemia, inhibition and biochemical parameters. Results:The extract contains flavonoids, alkaloids, steroids, tannins, terpernoids, glycosides and saponins. It has high flavonoids (9.04 mg) quantity and low steroids (0.41 mg) quantity. The acute toxicity study of the extract showed no mortality with 3162 mg/kg as the lethal dose 50. The extract exhibited significant (p < 0.05) curative, suppressive and prophylactic antiplasmodial activities in a dose-related fashion when compared to parasitized control. Curatively, the extract (250, 500 and 1000 mg/kg) produced 84.81%, 90.70% and 95.63% parasitemia inhibitions, respectively while CQ produced 94.31% parasitemia inhibition. MST was increased by the extract in a dosedependent fashion when compared to parasitized control. The altered haematological parameters were restored by the extract in a dose-dependent fashion when compared to parasitized control. The acute toxicity study of the extract (250, 500 and 1000 mg/kg) significantly impaired renal and liver function biomarkers in a dose-related fashion when compare to normal control at p < 0.05, p < 0.01 and p < 0.001, respectively. Conclusion:Chromolaena odorata leaf extract has promising antiplasmodial activity.

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Biological activities of Chromolaena odorata: A mechanistic review

Cited by 24 publications

References 102 publications

Evolution of the Secondary Metabolites in Invasive Plant Species Chromolaena odorata for the Defense and Allelopathic Functions

Evolution of the Secondary Metabolites in Invasive Plant Species Chromolaena odorata for the Defense and Allelopathic Functions

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

Toxicity and Antiplasmodial Assessments of Chromolaena odorata Leaf Extract on Plasmodium berghei-Infected Mice

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