Biological Activities of Artemisinins Beyond Anti-Malarial: a Review

Saeed-ur-Rahman,; Khalid, Muhammad Fasih; Kayani, Sadaf‐Ilyas; Jan, Farooq; Ullah, Ayaz; Tang, Kexuan

doi:10.1007/s12042-019-09228-0

Cited by 12 publications

(3 citation statements)

References 133 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 2. Artemisinin and its derivatives for the treatment of different diseases (Rahman et al, 2019 The most important pharmacological properties of artemisinin are anti-malarial activity, antiviral, antibacterial, antihelminthis, antiprotozoa, antifungal, anti-inflammatory and anti-tumor properties (Zyad et al, 2017;Qiu et al, 2018). Phenolics enhance artemisinin water solubility and extraction efficiency as phenolics, mainly chlorogenic acids, are highly present in teas from A. annua (Carbonara et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science

Shahrajabian

Sun

Cheng

2020

Not Bot Horti Agrobo

View full text Add to dashboard Cite

Artemisia annua L. (Chinese wormwood herb, Asteraceae) synthesizes artemisinin, which is known as qinghaosu, considers as a unique sesquiterpene endoperoxide lactone. In traditional Chinese medicine, it has been used for the treatment of fevers and haemorrhoides. More researches on Artemisia annua L. and its derivatives, especially artemisinin and other metabolites will help to increase the knowledge and value of A. annua and its constituents. Phenolics from Artemisia annua consists of coumarins, flavones, flavonols, phenolic acids, and miscellaneous. Artemisinin has attracted much attention from scientists due to its potent antimalarial properties as secondary metabolites. Moreover, more attentions are focusing on the roles of artemisinin and its derivatives in treating obesity and metabolic diseases. They also have anti-bacterial, anti-inflammatory, anti-tumor, anti-protozoa, anti-helminthic, anti-fungal, anti-angiogenic and antiproliferation properties. The most important derivatives of Artemisia annua L. are arteether, artemether, artemiside, artemisinin, artemisone, artesunate, and dihydroartemisinin. Artemisinin also use against some cancers such as liver cancer, brain glioma, leukemia, nasopharyngeal cancer, gallbladder cancer, gastric cancer, cervical cancer, lung cancer, breast cancer and colon cancer. This important gift from ancient Chinese traditional medicine can guarantee health of people all around the world. Further researches should be done on the new advances and development of artemisinin and its derivatives as potential natural medicine in the global fight against so many diseases, malaria included.

show abstract

Section: Introductionmentioning

confidence: 99%

Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science

Shahrajabian

Sun

Cheng

2020

Not Bot Horti Agrobo

View full text Add to dashboard Cite

show abstract

“…However, there are some pharmacokinetic limitations in application of artemisinin, including poor solubility in water, short half-life in vivo and limited bioavailability [2] . For this reason, artemisinin derivatives, such as dihydroartemisinin, artemether, arteether and artesunate, are synthesized based on the molecular structure of artemisinin to enhance its biological function [3] . Artemisinin and its derivatives are active against not only plasmodium but also schistosome, pathogens and insects [4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Computer simulation and prediction of spectral and molecular properties of artemisinin

Zeng,

Meng,

et al. 2024

Third International Conference on Biomedical and Intelligent Systems (IC-BIS 2024)

View full text Add to dashboard Cite

In order to study the molecular properties and pharmacological activity of artemisinin, computer high performance computing (HPC) and density functional theory (DFT) were used to simulate and calculate the structure of this drug. The microscopic structure characteristics of artemisinin were obtained, the electrostatic potential (ESP) distribution and its infrared spectrum (IR), ultraviolet-visible absorption spectrum (UV) and fluorescence spectra in artemisinin were simulated and predicted. It was concluded that artemisinin could be used for characteristic absorption detection of infrared vibration, and artemisinin could be quantitatively detected by ultraviolet absorption spectrum and molecular fluorescence spectrum. More importantly, it was confirmed that artemisinin molecules required low energy to be activated, and had active molecules of nucleophilic and electrophilic reactions. It was expected to provide reference and guidance for the structural properties of artemisinin and the modification of artemisinin-like drugs molecules.

show abstract

“…In view of the rapid development of parasite resistance to antimalarial drugs, the World Health Organization (WHO) has endorsed the artemisinin-based combination therapies as the first-line treatment for uncomplicated malaria caused by Plasmodium falciparum (Ye et al, 2016). Apart from its antimalarial activities, artemisinin is also a multi-functional compound that is associated with a variety of novel biological properties, such as immunoregulatory, anticancer, antituberculosis, antidiabetic, antiparasitic and antiviral functions (Li et al, 2017;Saeed-ur-Rahman et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Effects of UV-B and DMSO Treatments on the Production of Artemisinin in Low-Artemisinin Producing Artemisia annua Cell Cultures

Yee¹,

Ping²

2021

JTPP

View full text Add to dashboard Cite

Artemisinin is a sesquiterpene lactone derived from Artemisia annua L., and has a variety of biological properties, such as immunoregulatory and anticancer effects, and therapeutic applications. As a result of its naturally low production and compartmentalised synthesis, the irregular agricultural supply often leads to price fluctuations and reduction of the artemisinin inventory. In this study, elicitation efficiencies of ultraviolet B (UV-B) and dimethyl sulfoxide (DMSO) on a low-artemisinin producing (LAP) chemotype of the species A. annua were investigated. Exposure of cell suspension cultures to short-term UV-B radiation and DMSO treatment did not result in significant changes in artemisinin yield. The lack of stimulation could be associated with the growth condition such as the incubation duration after treatment, the physiological state of suspension-cultured cells, and the regulation of cellular metabolic homeostasis. Further molecular analysis with RT-PCR revealed the absence of mRNA transcripts of key genes ADS, DBR2, and ALDH1 which might affect artemisinin synthesis. This study demonstrated the complexity of stress-induced responses of cell suspension cultures in relation to metabolic processes which are important for artemisinin formation.

show abstract

Biological Activities of Artemisinins Beyond Anti-Malarial: a Review

Cited by 12 publications

References 133 publications

Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science

Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science

Computer simulation and prediction of spectral and molecular properties of artemisinin

Effects of UV-B and DMSO Treatments on the Production of Artemisinin in Low-Artemisinin Producing Artemisia annua Cell Cultures

Contact Info

Product

Resources

About