Biological Activities and Phytochemicals of Swietenia macrophylla King

Abstract

Swietenia macrophylla King (Meliaceae) is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the World. S. macrophylla has been widely used in folk medicine to treat various diseases. The review reveals that limonoids and its derivatives are the major constituents of S. macrophylla. There are several data in the literature indicating a great variety of pharmacological activities of S. macrophylla, which exhibits antimicrobial, anti-inflammatory, antioxidant effects, antimutagenic, anticancer, antitumor and antidiabetic activities. Various other activities like anti-nociceptive, hypolipidemic, antidiarrhoeal, anti-infective, antiviral, antimalarial, acaricidal, antifeedant and heavy metal phytoremediation activity have also been reported. In view of the immense medicinal importance of S. macrophylla, this review aimed at compiling all currently available information on its ethnomedicinal uses, phytochemistry and biological activities of S. macrophylla, showing its importance.

In Vitro anti-leismanial activity of Malaysian medicinal and forest plant species

“…It is a large tropical tree with a height reaching more than 30 m, and widely distributed around the world including America, India, China, Malaysia and Indonesia (Goh & Abdul Kadir 2011, Moghadamtousi et al 2013). This amazing tree has a wide range of application from traditional medicinal to pharmacological activity, and also in the timber industry.…”

“…Anti-inflammatory activity (IC 50 ≤ 35.7 µM) was reported from six tetranortriterpenes compounds (6-O-acetyl-3'-demethylswietephragmin E, 3,6-O,Odiacetylswietenolide, 3-O-tigloylswietenolide, 3 -O -t i g l o y l -6 -O -a c e t y l s w i e t e n o l i d e , swietemahonon E and 6-O-acetylswietemahonon G) (Chen et al 2010). Phytochemical constituents of the plant were largely of limonoids and its derivatives which contributed to its wide ethnomedicinal benefits (Moghadamtousi et al 2013). Major compounds from class of limonoids had been isolated and identified such as swietenine, swietenolide, swietenolide diacetate and their derivatives (Mootoo et al 1999, Falah et al 2008.…”

ACUTE ORAL TOXICITY FROM A FRACTION RICH IN PHENOLIC COMPOUNDS FROM THE LEAF EXTRACT OF Swietenia macrophylla KING IN A MURINE MODEL

“…The Mahogany tree (Swietenia macrophylla King), which can usually reach 40 to 60 meters, belongs to the Meliaceae family and has a tropical distribution found in Central and South America, in Western India, in Malaysia and in the central and southern China (1,2). This plant is used in Asia for the treatment of various diseases based on their antimicrobial effects, anti-inflammatory, antioxidant, anti-mutagenic, anti-cancer, anti-tumor and anti-diabetic activities (2).…”

“…This plant is used in Asia for the treatment of various diseases based on their antimicrobial effects, anti-inflammatory, antioxidant, anti-mutagenic, anti-cancer, anti-tumor and anti-diabetic activities (2). Its seeds have many uses, such as in the traditional treatment of hypertension, diabetes and to relieve pain in Malaysia, to treat leishmaniosis and to induce abortion in Bolivia, as well as for the treatment of diabetes, hypertension and malaria in Indonesia.…”

“…Its seeds have many uses, such as in the traditional treatment of hypertension, diabetes and to relieve pain in Malaysia, to treat leishmaniosis and to induce abortion in Bolivia, as well as for the treatment of diabetes, hypertension and malaria in Indonesia. In addition, its bark is used as an astringent for wounds and occasionally for sun tanning (2)(3)(4)(5)(6).…”