Biological actions of curcumin on articular chondrocytes

Henrotin, Yves; Clutterbuck, A.L.; Allaway, David; Lodwig, E. M.; Harris, Pat; Mathy-Hartert, M.; Shakibaei, Mehdi; Mobasheri, Ali

doi:10.1016/j.joca.2009.10.002

Cited by 149 publications

(138 citation statements)

References 60 publications

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“…NF-κB contributes to the increased transcription of COX-2 and other pro-inflammatory genes, such as inducible nitric oxide synthase (iNOS). Curcumin also increases the accumulation of glutathione, an important intracellular antioxidant, and inhibits the activity of inflammatory enzymes [37].…”

Section: Resultsmentioning

confidence: 99%

Formulations Containing Curcumin or Trans-Resveratrol Increase Dermal Thickness in Rats Submitted to Chemical Peeling

Gonçalves¹,

Barros²,

Silva³

et al. 2017

JCDSA

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Plant-derived substances such as curcumin and trans-resveratrol, both of which have anti-inflammatory properties, may have a beneficial effect on human skin. The present study analyzed the effects of topical formulations containing curcumin or trans-resveratrol on the recovery and rejuvenation of skin after chemical peeling. The study was performed on rats, randomly divided into seven groups of six animals each. Superficial peeling was performed using a 50% glycolic acid gel, which was applied to the dorsal region of each animal. Rats were then treated with the experimental formulations for 15 days. On the sixteenth day, skin samples were taken and mounted on slides for histological analysis. Statistical analysis showed that the formulation containing transresveratrol led to increased dermal and epidermal thickness, while the formulation containing curcumin had no effects on epidermal thickness. The increased epidermal thickness may reflect greater skin vitality, although this was not directly evaluated. The increase in dermal thickness may be attributed to greater collagen production, which may increase skin firmness and elasticity, and lead to skin rejuvenation as well as wrinkle reduction. Formulations containing curcumin or trans-resveratrol may have potential for the topical treatment after peeling and of sensitive skin, in addition to being used for their antiaging properties.

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Section: Resultsmentioning

confidence: 99%

Formulations Containing Curcumin or Trans-Resveratrol Increase Dermal Thickness in Rats Submitted to Chemical Peeling

Gonçalves¹,

Barros²,

Silva³

et al. 2017

JCDSA

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“…They are aggrecanases and aggrecan aggregation of proteoglycans and one of the components of ECM. After degradation of aggrecans by these enzymes, MMP-3 acts in synergism in the degradation of proteoglycans [8, [15][16][17].…”

Section: Physiopathology and Cartilage Destructionmentioning

confidence: 99%

“…There is increased release of reactive oxygen species (ROS), mainly nitric oxide (NO), peroxynitrite (ONOO À ), and superoxide anion radicals (O2 À ). Other inflammatory mediators such as cyclooxygenase-2 (COX-2), produced by synovial monocytes, and prostaglandins 2 (PGE2) are also involved in the pathophysiology of the disease [6,15].…”

Section: Physiopathology and Cartilage Destructionmentioning

confidence: 99%

“…Thus, IKB-α is degraded by ubiquitination, and the dimers compounded by p50 and p65 reach the nucleus and can stimulate the expression of more than 400 genes, of which some are proinflammatory and pro-apoptotic genes [8,18]. Therefore, there is production of various interleukins, including IL-1, IL-6, IL-8, and IL-10 [8, 15,16].…”

Section: Physiopathology and Cartilage Destructionmentioning

confidence: 99%

“…Moreover, curcumin has been shown to inhibit the activator protein 1 (AP-1) pathway and NF-κB leading to the suppression of the production of MMP-3, MMP-9, and MMP-13 [15,19]. Zhang et al [9] demonstrated in a mouse model that the production of MMP-1, MMP-3, MMP-13, IL-1β,TNF-α, and ADAMTS5 was decreased when the animals were treated with curcumin.…”

Section: The Potential Effects Of Curcuma Longamentioning

confidence: 99%

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Alternative Therapeutic Approach for Cartilage Repair

Akuri¹,

Barion²,

Barbalho³

et al. 2018

Cartilage Repair and Regeneration

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The cartilage is a flexible tissue, which supports the adjacent soft tissues. The damages that cause degenerative articular diseases are marked by the increase of cytokines such as tumor necrosis factor-α (TNF-α), IL-1β, IL-6, IL-18, and IL-17, which cause intense inflammatory process and release of metalloproteinases and disintegrin enzymes that lead to cartilage degradation. The Curcuma longa possessesbioactivecompoundsdesignatedascurcuminoids that display therapeutic potential in several pathologies. Curcumin is one of these compounds that may exhibit anti-inflammatory, antioxidant, antiviral, antibacterial, and antitumor effects. It may promote decrease of IL-1β,IL-6,IL-8,TNF-α,COX-2,andreactive oxygen species. Furthermore, curcumin inhibits the activity of several kinases related to the degradation of the cartilage, including tyrosine kinase, p21-activated kinase, mitogenactivated protein kinase, protein kinase C, the activator protein 1 pathway, and NF-κB leading to the suppression of the production of metalloproteinases and inflammatory cytokines. Curcumin has also been related to the stimulation of the production of type II collagen and glycosaminoglycan by chondrocytes. Studies have shown that this compound may alleviate joint pain and crepitation, reduce the use of other drugs for pain relief, stimulate the production of type II collagen and glycosaminoglycan resulting in a protective and antiinflammatory action of cartilage and bones, and improve the quality of life of the patients.

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In Vivo Luminescence Imaging of NF‐κB Activity and Serum Cytokine Levels Predict Pain Sensitivities in a Rodent Model of Osteoarthritis

Bowles

Mata

Bell

et al. 2014

Arthritis & Rheumatology

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Objective To investigate the relationship between NF-κB activity, cytokine levels, and pain sensitivities in a rodent model of osteoarthritis (OA). Method OA was induced in transgenic NF-κB luciferase reporter mice via mono-iodoacetate (MIA) intra-articular injection. Using luminescent imaging we evaluated the temporal kinetics of NF-κB activity and its relationship to the development of pain sensitivities and serum cytokine levels in this model. Results MIA induced a transient increase in joint-related NF-κB activity at early time points (day 3 post-injection) and an associated biphasic pain (mechanical allodynia) response. NF-κB activity, serum IL-6, IL-1β, and IL-10 accounted for ~75% of the variability in pain-related mechanical sensitivities in this model. Specifically, NF-κB activity was strongly correlated to mechanical allodynia and serum IL-6 levels in the inflammatory pain phase of this model (day 3), while serum IL-1β was strongly correlated to pain sensitivities in the chronic pain phase of the model (day 28). Conclusion Our findings suggest that NF-κB activity, IL-6 and IL-1β may be playing distinct roles in pain sensitivity development in this model of arthritis and may act to distinguish the acute from chronic pain phases of this model. This work establishes luminescent imaging of NF-κB activity as a novel imaging biomarker of pain sensitivities in this model of OA.

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Biological actions of curcumin on articular chondrocytes

Cited by 149 publications

References 60 publications

Formulations Containing Curcumin or Trans-Resveratrol Increase Dermal Thickness in Rats Submitted to Chemical Peeling

Formulations Containing Curcumin or Trans-Resveratrol Increase Dermal Thickness in Rats Submitted to Chemical Peeling

Alternative Therapeutic Approach for Cartilage Repair

In Vivo Luminescence Imaging of NF‐κB Activity and Serum Cytokine Levels Predict Pain Sensitivities in a Rodent Model of Osteoarthritis

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