Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene

Tsai, Hui Yun; Ho, Chi Tang; Chen, Yu-Kuo

doi:10.1016/j.jfda.2016.07.004

Cited by 187 publications

(160 citation statements)

References 84 publications

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“…Furthermore, a drastic decline of p-mTOR/mTOR ratio and significantly increased protein levels of Beclin-1 were found. Although similar results were found in resveratrol-treated animals and the offspring after maternal resveratrol exposure [55,67], here it is shown that beneficial effects of resveratrol were maintained unexpectedly across generations. Of paramount importance is to demonstrate that molecular mechanisms implicated in transgenerational and intergenerational resveratrol effects occur through are the same that in direct contact with the polyphenol, reinforcing the importance of epigenetic machinery in the inheritance across generations.…”

Section: Discussionsupporting

confidence: 86%

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Izquierdo¹,

Palomera-Ávalos²,

López-Ruiz³

et al. 2019

Preprint

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A variety of environmental factors contribute significantly to age-related cognitive decline and Alzheimer’s Disease (AD). Nutrition can alter epigenetics, improving health outcomes, which transmitted across generations; this process is called epigenetic inheritance. We investigate the beneficial effects of maternal resveratrol supplementation in offspring. We feed females SAMP8 with resveratrol-enriched diet during two months prior to mating. Direct exposed F1 generation and the transgenerational F2 generation were investigated. Object novel recognition and Morris water maze demonstrated improvements in cognition in the 6-month-old F1 and F2 generations from resveratrol fed mothers. A significant increase in global DNA methylation with a decrease in hydroxymethylation in F1 and F2 were found. Accordingly, Dnmt3a/b and Tet2 gene expression changed. Methylation levels of Nrf2 and NF-kβ genes promoters raised in offspring, inducing changes in target genes expression, as well as hydrogen peroxide levels. Offspring resulted from resveratrol fed mother showed increase AMPKα activation, mTOR inhibition and an increase in Pgc-1α gene expression and Beclin-1 protein levels. Endoplasmic reticulum stress sensors were found changed both in F1 and F2 generations. Overall, our results demonstrated that maternal resveratrol supplementation could prevent cognitive impairment in the SAMP8 mice offspring through epigenetic changes and cell signaling pathways.

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Section: Discussionsupporting

confidence: 86%

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Izquierdo¹,

Palomera-Ávalos²,

López-Ruiz³

et al. 2019

Preprint

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“…Furthermore, 4 flavonoid compounds (aesculin, phlorizin, coniferyl aldehyde, and eriodictyol) as well as 1 stilbene (pterostilbene) were detected for the first time in quinoa seeds, but their concentration was very low (range from 0.08 to 0.53 mg/kg DW). However, despite the low concentration, their role as chemopreventive and chemotherapeutic agents might be important (Tsai, Ho, & Chen, 2017).…”

Section: Resultsmentioning

confidence: 99%

Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars

et al. 2020

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Background and objectives Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health‐promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time‐dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT‐116, as well as the presence of 7 new phenolic and flavonoid compounds.

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“…Pterostilbene (3,5‐dimethoxy‐4′‐hydroxy‐ trans ‐stilbene) is a methylated analog of resveratrol with two methoxy groups on the A ring and one hydroxyl group on the B ring. Pterostilbene has been identified in blueberries and grape products and has attracted much attention because of its chemopreventive and chemotherapeutic effects . The substitution of the hydroxy groups with methoxy groups is believed to increase the stability and lipophilicity of pterostilbene compared to those of resveratrol, which leads to better membrane permeability, cellular uptake, and bioavailability .…”

Section: An Overview Of Resveratrol and Pterostilbenementioning

confidence: 99%

“…Pterostilbene has been identified in blueberries and grape products and has attracted much attention because of its chemopreventive and chemotherapeutic effects . The substitution of the hydroxy groups with methoxy groups is believed to increase the stability and lipophilicity of pterostilbene compared to those of resveratrol, which leads to better membrane permeability, cellular uptake, and bioavailability . The 3,5‐dimethoxy motif on the A phenyl ring of pterostilbene is considered important for its pro‐apoptotic activity in cancer cells .…”

Section: An Overview Of Resveratrol and Pterostilbenementioning

confidence: 99%

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

Pan

et al. 2018

BioFactors

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Obesity is a current global epidemic that has led to a marked increase in metabolic diseases. However, its treatment remains a challenge. Obesity is a multifactorial disease, which involves the dysfunction of neuropeptides, hormones, and inflammatory adipokines from the brain, gut, and adipose tissue. An understanding of the mechanisms and signal interactions in the crosstalk between organs and tissue in the coordination of whole-body energy metabolism would be helpful to provide therapeutic and putative approaches to the treatment and prevention of obesity and related complications. Resveratrol and pterostilbene are well-known stilbenes that provide various potential benefits to human health. In particular, their potential anti-obesity effects have been proven in numerous cell culture and animal studies. Both compounds act to regulate energy intake, adipocyte life cycle and function, white adipose tissue (WAT) inflammation, energy expenditure, and gut microbiota by targeting multiple molecules and signaling pathways as an intervention for obesity. Although the efficacy of both compounds in humans requires further investigation with respect to their oral bioavailability, promising scientific findings have highlighted their potential as candidates for the treatment of obesity and the improvement of obesity-related metabolic diseases. © 2018 BioFactors, 44(1):50-60, 2018.

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Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene

Cited by 187 publications

References 84 publications

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars

Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene

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