Biologic therapies for severe asthma with persistent type 2 inflammation
Sahan Chandrasekara,
Peter Wark
Abstract:SUMMARY
Asthma is a chronic inflammatory airways disease with reversible airflow obstruction, characterised in the majority by type 2 airway inflammation.
Type 2 inflammation results in secretion of interleukin-4, -5 and -13 in the airways, recruitment of inflammatory cells (especially eosinophils and mast cells), and airway changes such as mucus hypersecretion and increased airway reactivity.
Approximately 5 to 10% of people with asthma, despite optimal therapy and adherence t… Show more
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