Biologic Responses of Autogenous Bone and Beta-tricalcium Phosphate Ceramics Transplanted into Bone Defects to Orthodontic Forces

Abstract

This study was conducted to evaluate biologic responses of autogenous bone (particulate marrow and cancellous bone; PMCB) and beta-tricalcium phosphate ceramics (TCPC) to orthodontic stimuli. Nine dogs served as the experimental animals; three dogs underwent orthodontic tooth movement after grafting, three dogs received PMCB grafting without tooth movement, and three dogs received TCPC grafting without tooth movement. Immediately after extraction of the upper second and/or third incisors, the maxillary alveolar bone was resected bilaterally. Autogenous PMCB obtained from the iliac bone and TCPC were transplanted into each bone defect. Experimental tooth movement was initiated 2 to 4 weeks after the grafting and continued for 9 to 15 weeks. Sectional archwires with open-coll springs were used for distal movement of the upper first incisors into the extraction sites. Oxytetracycline and calcein were employed as bone markers. Sections of grafted areas including the teeth were prepared for light and fluorescence microscopy. The results revealed that both autogenous bone and TCPC presented similar adaptive changes to the original alveolar bone without any external stimuli. TCPC exhibited more prominent biodegradative responses to orthodontic force in association with new cementum formation. Root resorption was also less in the TCPC area than in the PMCB region. It is shown that TCPC is biodegradative in nature and adaptive for remodeling during orthodontic tooth movement. This finding indicates that TCPC may be a better biocompatible alternative to autogenous bone transplanted into bone defects subjected to orthodontic tooth movement.

Lack of bone healing: an unusual complication following surgically assisted rapid palatal expansion

“…There was only mesial tipping of incisors as a result of gingival fibres stretching in response to the forces applied during the expansion. Autogenous bone grafting to fill the bony defect provided a continuous alveolar crest, offering support for mesial root movement by orthodontic treatment. The functional recovery after bone grafting by teeth movement prevents additional bone resorption.…”

“…There was no evidence of root resorption in the central incisors, contrary to that described in previous reports. Root resorption was reported as a consequence of orthodontic tooth movement, which was not performed during bone graft healing.…”

Protocolo de extracciones en ortodoncia

“…Este tipo de procedimientos está indicado en casos en los que vaya a pasar un gran lapso de tiempo entre el momento de realizar la extracción y el momento del cierre del espacio, disminuyendo con estos procedimientos el riesgo de colapso del reborde [4,[42][43][44][45][46].…”

Augmentation and Preservation of the Alveolar Process and Alveolar Ridge of Bone

“…β-TCP is biocompatible (Rosa et al 1995, Hossain et al 1996, Ohsawa, et al 2000 , ,and achieves favorable volumetric maintenance. (Breitbart et al 1995, ;Gao et al 1997) In a comparative histomorphometric study in miniature pigs (Merten et al 2001), β-TCP has shown very favorable qualities of biodegradation and substitution.…”