Biologic Markers in Lung Cancer

Vincent, Ronald G.

doi:10.1055/s-2007-1012194

Cited by 7 publications

(2 citation statements)

References 41 publications

(48 reference statements)

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“…It has been suggested that biochemical and immunological tumour markers in serum are helpful in the diagnosis of cancer [21,22]. The measurement of tumour markers in BALF is also useful in diagnosing lung cancer that is not visible endoscopically [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Elevation of tumour markers in serum and bronchoalveolar lavage fluid in pulmonary alveolar proteinosis

Hirakata¹,

Kobayashi²,

Sugama³

et al. 1995

Eur Respir J

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It is unclear whether tumour markers are generally increased in the serum and bronchoalveolar lavage fluid (BALF) of patients with pulmonary alveolar proteinosis (PAP). To clarify this point, levels of tumour markers were measured in the serum and BALF of patients with PAP. Squamous cell carcinoma (SCC) antigen, carcinoembryonic antigen (CEA), and carbohydrate antigens sialyl Lewis (CA 19-9) and sialyl SSEA-1 (SLX) were assayed with radioimmunoassay kits. Cytokeratin 19 fragments (CYFRA) were measured by enzyme-linked immunosorbent assay. Values for the tumour markers in serum, except for SCC, exceeded cut-off values in some PAP patients. Levels of the markers were higher in BALF compared with those in serum, and were significantly elevated in PAP patients compared with control subjects. There was a significant inverse correlation between CA19-9 level in BALF and arterial oxygen tension (PaO2) in PAP patients. A gradual elevation of CA19-9 and SLX was observed in a patient who showed a decrease in PaO2 level during the study period. In the light of these findings, it is possible that levels of tumour markers in BALF, especially levels of CA19-9 and SLX, may reflect the severity of the disease in PAP patients.

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Section: Discussionmentioning

confidence: 99%

Elevation of tumour markers in serum and bronchoalveolar lavage fluid in pulmonary alveolar proteinosis

Hirakata¹,

Kobayashi²,

Sugama³

et al. 1995

Eur Respir J

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“…Maxim et al 34) reported an increase in ferritin levels in lung cancer tissue. Serum ferritin, together with carcino-embryonic antigen (CEA), has been reported to be useful in indicating tumor recurrence and thus in postoperative follow up 35 , 36) .…”

Section: Discussionmentioning

confidence: 99%

Ferritin Assay in Malignant Pleural Effusion

Chung

Lee

Park

et al. 1987

Korean J Intern Med

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In order to assess the usefulness of ferritin as a tumor marker, the authors measured and analyzed pleural fluid and serum ferritin concentrations by double antibody radioimmunoassay method in 20 patients with malignant pleural effusion, and in 39 patients with benign pleural effusion. Serum ferritin levels were also measured in a control group of 20 healthy people.The results obtained are summarized as follows: 1) Pleural fluid ferritin levels in the malignant pleural effusion group were significantly higher (p<0.001) than those of the benign pleural effusion group.2) As one of the criteria in differentiating between malignant and benign pleural effusion, the differentiating pleural fluid ferritin level was set at 2,000 ng/ml, a specificity up to 75.0% and sensitivity of 89.7% could be obtained.3) Serum ferritin levels in the malignant pleural effusion group were significantly higher (p<0.001) than those in the control group.4) There was no statistically significant correlation between pleural fluid and serum ferritin levels in the malignant pleural effusion group.From the above results, it can be concluded that it is possible to use pleural fluid ferritin levels as a tumor marker.

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Pathophysiologie von Lunge, Herz, Stoffwechsel und anderen Organen bei Bronchialkarzinomen

Konietzko¹

1985

Tumoren Der Atmungsorgane Und Des Mediastinums A

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Biologic Markers in Lung Cancer

Cited by 7 publications

References 41 publications

Elevation of tumour markers in serum and bronchoalveolar lavage fluid in pulmonary alveolar proteinosis

Elevation of tumour markers in serum and bronchoalveolar lavage fluid in pulmonary alveolar proteinosis

Ferritin Assay in Malignant Pleural Effusion

Pathophysiologie von Lunge, Herz, Stoffwechsel und anderen Organen bei Bronchialkarzinomen

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