Biologic effect of neurogenesis in pancreatic cancer

He, Dandan; Manzoni, Adriana; Florentin, Diego; Fisher, William E.; Ding, Yi; Lee, Minjae; Ayala, Gustavo

doi:10.1016/j.humpath.2016.02.001

Cited by 34 publications

(25 citation statements)

References 30 publications

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“…It was reported that neural microenvironment may play an important role in the progression of pancreatic cancer and prostate cancer. 21,22 Thus, the potential clinical value of our research could be directed to other than locally advanced breast cancer where medical treatments (chemotherapy and/or endocrine therapy) and radiotherapy play a crucial role. Moreover, substance P, released by sensory neurons, has been shown reportedly to enhance breast cancer growth and metastases, 23 and when reviewing the literature, there are several recent publications on the suppressive effect of sympathectomy on tumor growth.…”

Section: Discussionmentioning

confidence: 99%

Denervation leads to volume regression in breast cancer

Kappos

Engels

Tremp

et al. 2018

Journal of Plastic, Reconstructive & Aesthetic Surgery

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The nervous system plays a key role in controlling the dynamic functions of multicellular complex organisms. Although peripheral nerves are supposed to play a pivotal role in tumor growth and dissemination, little experimental evidence exists to date. We assessed the effect of denervation on breast cancer growth by magnetic resonance imaging (MRI) in rats. Human breast cancer cells were implanted into adipofascial flaps with intact or surgically excised supplying nerve. Tumor volumes were measured 2 and 8 weeks after implantation by in vivo MRI. Results were validated by histology. Postoperative tumor volumes at 2 and 8 weeks were reduced by 76% (95% CI: 22-93%) in the denervated groups. Tumor area as determined histologically was reduced by 70% (95% CI: 60-78%). Thus, peripheral denervation may be an effective surgical approach for the palliative treatment of locally progressing or uncontrollable breast cancer.

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Section: Discussionmentioning

confidence: 99%

Denervation leads to volume regression in breast cancer

Kappos

Engels

Tremp

et al. 2018

Journal of Plastic, Reconstructive & Aesthetic Surgery

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“…This category includes 14 studies. In three studies, investigators injected BoNT into a malignant tumor and demonstrated cellular apoptosis and reduction of tumor size [57][58][59] (Table 3). In another six studies, adding BoNT-A to cancer cell cultures reduced cell growth, induced apoptosis, and inhibited mitosis in various cancer cell lines: Prostate, breast, colon, and pancreatic tumors [60][61][62][63][64][65].…”

Section: The Effects Of Botulinum Neurotoxins Injections On Malignantmentioning

confidence: 99%

Botulinum Neurotoxins and Cancer—A Review of the Literature

Mittal

Jabbari

2020

Toxins

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Botulinum neurotoxins (BoNT) possess an analgesic effect through several mechanisms including an inhibition of acetylcholine release from the neuromuscular junction as well as an inhibition of specific pain transmitters and mediators. Animal studies have shown that a peripheral injection of BoNTs impairs the release of major pain transmitters such as substance P, calcitonin gene related peptide (CGRP) and glutamate from peripheral nerve endings as well as peripheral and central neurons (dorsal root ganglia and spinal cord). These effects lead to pain relief via the reduction of peripheral and central sensitization both of which reflect important mechanisms of pain chronicity. This review provides updated information about the effect of botulinum toxin injection on local pain caused by cancer, painful muscle spasms from a remote cancer, and pain at the site of cancer surgery and radiation. The data from the literature suggests that the local injection of BoNTs improves muscle spasms caused by cancerous mass lesions and alleviates the post-operative neuropathic pain at the site of surgery and radiation. It also helps repair the parotid damage (fistula, sialocele) caused by facial surgery and radiation and improves post-parotidectomy gustatory hyperhidrosis. The limited literature that suggests adding botulinum toxins to cell culture slows/halts the growth of certain cancer cells is also reviewed and discussed.

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“…The PNI is the best known form of cancer-nerve crosstalk in PC. Recently, there is increasing data pointing to the role of axonogenesis and neoneurogenesis in PC biology [31,62,63]. The other related topics are molecules involved in tumor-neural TME interactions, with 3 main classes of proteins: neurotrophic factors, axon guidance molecules and NT including neuropeptides.…”

Section: Pc Stroma and Its Neural Componentmentioning

confidence: 99%

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

et al. 2020

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The tumor microenvironment (TME) plays an essential role in the development and progression of neoplasms. TME consists of the extracellular matrix and numerous specialized cells interacting with cancer cells by paracrine and autocrine mechanisms. Tumor axonogenesis and neoneurogenesis constitute a developing area of investigation. Prostate cancer (PC) is one of the most common malignancies in men worldwide. During the past years, more and more studies have shown that mechanisms leading to the development of PC are not confined only to the epithelial cancer cell, but also involve the tumor stroma. Different nerve types and neurotransmitters present within the TME are thought to be important factors in PC biology. Moreover, perineural invasion, which is a common way of PC spreading, in parallel creates the neural niche for malignant cells. Cancer neurobiology seems to have become a new discipline to explore the contribution of neoplastic cell interactions with the nervous system and the neural TME component, also to search for potential therapeutic targets in malignant tumors such as PC.

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Biologic effect of neurogenesis in pancreatic cancer

Cited by 34 publications

References 30 publications

Denervation leads to volume regression in breast cancer

Denervation leads to volume regression in breast cancer

Botulinum Neurotoxins and Cancer—A Review of the Literature

Complexity of Neural Component of Tumor Microenvironment in Prostate Cancer

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