Biologic Activity and Biotechnological Development of Natural Products

Carvalho, José Carlos Tavares; Perazzo, Fábio Ferreira; Machado, Leandro dos Santos; Béreau, Didier

doi:10.1155/2013/971745

Cited by 11 publications

(10 citation statements)

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“…The 9L cells were relatively more sensitive to all of the formulations, as compared with the U87MG cells. The difference in the cytotoxic effects on both of the cell lines may be attributed to the difference in genetic origin and indigenous biological behavior (20). In order to precisely quantify the effects of the individual therapeutic systems, the half maximal inhibitory concentration (IC 50 ) was evaluated.…”

Section: Resultsmentioning

confidence: 99%

Efficient delivery of docetaxel for the treatment of brain tumors by cyclic RGD-tagged polymeric micelles

Zheng

Liu

et al. 2014

Molecular Medicine Reports

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The treatment of glioblastoma, and other types of brain cancer, is limited due to the poor transport of drugs across the blood brain barrier and poor penetration of the blood‑brain‑tumor barrier. In the present study, cyclic Arginine‑Glycine‑Aspartic acid‑D‑Tyrosine‑Lysine [c(RGDyK)], that has a high binding affinity to integrin αvβ3 receptors, that are overexpressed in glioblastoma cancers, was employed as a novel approach to target cancer by delivering therapeutic molecules intracellularly. The c(RGDyK)/docetaxel polylactic acid‑polyethylene glycol (DTX‑PLA‑PEG) micelle was prepared and characterized for various in vitro and in vivo parameters. The specific binding affinity of the Arginine‑Glycine‑Aspartic acid (RGD) micelles, to the integrin receptor, enhanced the intracellular accumulation of DTX, and markedly increased its cytotoxic efficacy. The effect of microtubule stabilization was evident in the inhibition of glioma spheroid volume. Upon intravenous administration, c(RGDyK)/DTX‑PLA‑PEG showed enhanced accumulation in brain tumor tissues through active internalization, whereas non‑targeted micelles showed limited transport ability. Furthermore, RGD‑linked micelles showed marked anti‑glioma activity in U87MG malignant glioma tumor xenografts, and significantly suppressed the growth of tumors without signs of systemic toxicity. In conclusion, the results of the present study suggest that ligand‑mediated drug delivery may improve the efficacy of brain cancer chemotherapy.

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Section: Resultsmentioning

confidence: 99%

Efficient delivery of docetaxel for the treatment of brain tumors by cyclic RGD-tagged polymeric micelles

Zheng

Liu

et al. 2014

Molecular Medicine Reports

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“…Evaluation and quantification of the biological activities of natural compounds are necessary before they are being offered to the market for human consumption. Besides exhibiting potentially beneficial therapeutic activities, other properties such as the toxic effect need to be recorded and thus require further characterization [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Wound Closure Activity of Nigella sativa, Melastoma malabathricum, Pluchea indica, and Piper sarmentosum Extracts on Scratched Monolayer of Human Gingival Fibroblasts

Rahman

Razak

Bakri

2014

Evidence-Based Complementary and Alternative Medicine

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Nigella sativa, Melastoma malabathricum, Pluchea indica, and Piper sarmentosum are common Asian traditional medicines to treat minor wounds. This study aimed to investigate the in vitro wound healing properties of aqueous extracts of these plants using human gingival fibroblast (HGF) monolayer as study model. DPPH scavenging activity of the extracts was evaluated and effect on HGF proliferation was determined. Their effect on HGF's function to synthesize collagen was indicated by the level of hydroxyproline produced and effect on wound healing activity was assessed using an in vitro scratch assay. The influence of the extracts on expression of bFGF and TGF-β was also determined. Results revealed all four extracts to exhibit low free radical scavenging activity. The extract from N. sativa (NSSE) compared to the others showed favourable enhancement of HGF proliferation with EC50 of 22.67 ± 3.06 µg/mL (P < 0.05) with accelerated wound closure activity despite its nonsignificant effect on collagen synthesis. In addition to the elevated level of bFGF by up to 15% at 100 µg/mL of NSSE, a slightly better effect was observed on the expression of TGF-β. NSSE thus showed that promising wound healing properties and data obtained may contribute towards validation of its traditional use for the healing of oral wounds.

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“…As mentioned previously, mulberry fruits are rich in anthocyanins [ 44 ], which have attracted attention of researchers and consumers because of their potential pharmacological activities on health [ 45 , 46 , 47 , 48 , 49 ]. Anthocyanins from mulberry fruits can inhibit the oxidation of low-density lipoprotein (LDL) and scavenge free radicals [ 33 , 50 ].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Effects of Mulberry Fruit (Morus alba L.) Consumption on Health Outcomes: A Mini-Review

et al. 2018

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Mulberry (Morus alba L.) belongs to the Moraceae family and is widely planted in Asia. Mulberry fruits are generally consumed as fresh fruits, jams and juices. They contain considerable amounts of biologically active ingredients that might be associated with some potential pharmacological activities that are beneficial for health. Therefore, they have been traditionally used in traditional medicine. Studies have reported that the presence of bioactive components in mulberry fruits, including alkaloids and flavonoid, are associated with bioactivities such as antioxidant. One of the most important compounds in mulberry fruits is anthocyanins which are water-soluble bioactive ingredients of the polyphenol class. Studies have shown that mulberry fruits possess several potential pharmacological health benefits including anti-cholesterol, anti-obesity and hepatoprotective effects which might be associated with the presence of some of these bioactive compounds. However, human intervention studies on the pharmacological activities of mulberry fruits are limited. Therefore, future studies should explore the effect of mulberry fruit consumption on human health and elucidate the detailed compounds. This paper provides an overview of the pharmacological activities of mulberry fruits.

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Biologic Activity and Biotechnological Development of Natural Products

Cited by 11 publications

References 0 publications

Efficient delivery of docetaxel for the treatment of brain tumors by cyclic RGD-tagged polymeric micelles

Efficient delivery of docetaxel for the treatment of brain tumors by cyclic RGD-tagged polymeric micelles

Evaluation of Wound Closure Activity of Nigella sativa, Melastoma malabathricum, Pluchea indica, and Piper sarmentosum Extracts on Scratched Monolayer of Human Gingival Fibroblasts

Effects of Mulberry Fruit (Morus alba L.) Consumption on Health Outcomes: A Mini-Review

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