Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties

Wang, Quan; Zhang, Ruirui; Lu, Mingzi; You, Guoxiang; Wang, Ying; Gan, Chunfang; Zhao, Caiyan; Wang, Zhen; Song, Xiang Rong; Wu, Yan; Zhao, Lei; Zhou, Hong

doi:10.1021/acs.biomac.7b00077

Cited by 88 publications

(102 citation statements)

References 42 publications

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“…In addition, the size changed from $7 to $10 nm when the mass ratio of starting DA/Hb increased, demonstrating that the thickness of the PDA film could be controlled by the starting mass ratio of DA/Hb, similar as the data of Jiang's research [29]. Figure 1(b) shows the UV-vis spectra of Hb-PDA nanoparticles, exhibiting a characteristic band around 280 nm, which demonstrates the generation of the PDA film [6]. The absorbance varied significantly owing to the different degrees of self-polymerization depending on the starting mass of DA.…”

Section: Influence Of Preparation Conditions On Hb-pda Nanoparticlessupporting

confidence: 74%

“…To study the effect of preparation conditions on Hb-PDA nanoparticles, the physicochemical properties of the particles were characterized. The polymerization of DA is immediate under mild conditions without requiring a complicated protocol and accompanied by a colour change from red to deep brown over time [6]. It should be noted that elevation of the mass ratios of DA/Hb can accelerate the deposition of PDA on the surface, leading to greater film thickness.…”

Section: Discussionmentioning

confidence: 99%

“…Hb-PDA nanoparticles showed protection of Hb by reducing the generation of MetHb, as well as excellent antioxidant properties by scavenging free radicals. Meanwhile, it also indicated that Hb-PDA nanoparticles reduced the intracellular hydrogen peroxide (H 2 O 2 )-induced reactive oxygen species generation [6].…”

Section: Introductionmentioning

confidence: 99%

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Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers

Wang

You

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Oxidative toxicity has impeded the development of haemoglobin-based oxygen carriers (HBOCs) by causing methaemoglobin (MetHb) formation and inducing oxidative stress. In our previous work, polydopamine-coated haemoglobin (Hb-PDA) nanoparticles have been designed and synthesized with the capacity to reduce oxidative toxicity. In this investigation, the mass ratio of dopamine (DA) to haemoglobin (Hb) and the pH value are found to be the primary factors that influence preparation of Hb-PDA nanoparticles. X-ray photoelectron spectroscopy showed that the catechol groups of DA play a crucial role in the modification of Hb surface. Hb-PDA nanoparticles were found to exhibit oxidative protection from hydrogen peroxide (HO) and the change of mitochondrial membrane potential showed that the Hb-PDA nanoparticles reduced HO-induced apoptosis. It is demonstrated that modification of PDA could maintain the oxygen-release capacity of Hb. These findings confirm that Hb-PDA nanoparticles possess restrained oxidative toxicity and preserve oxygen-release capacity.

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Section: Influence Of Preparation Conditions On Hb-pda Nanoparticlessupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers

Wang

You

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…The complexes between Hb and PDA were prepared by coincubating Hb and the monomer of dopamine hydrochloride (weight ratio ≈5:1) in solution at 25 °C under mild stirring . During the polymerization of dopamine over time, the solution of the mixture presented a progressive color change from dark red to dark brown.…”

Section: Methodsmentioning

confidence: 99%

Aggressive Man‐Made Red Blood Cells for Hypoxia‐Resistant Photodynamic Therapy

et al. 2018

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Extreme hypoxia of tumors represents the most notable barrier against the advance of tumor treatments. Inspired by the biological nature of red blood cells (RBCs) as the primary oxygen supplier in mammals, an aggressive man-made RBC (AmmRBC) is created to combat the hypoxia-mediated resistance of tumors to photodynamic therapy (PDT). Specifically, the complex formed between hemoglobin and enzyme-mimicking polydopamine, and polydopamine-carried photosensitizer is encapsulated inside the biovesicle that is engineered from the recombined RBC membranes. The mean corpuscular hemoglobin of AmmRBCs reaches about tenfold as high as that of natural RBCs. Owing to the same origin of outer membranes, AmmRBCs share excellent biocompatibility with parent RBCs. The introduced polydopamine plays the role of the antioxidative enzymes existing inside RBCs to effectively prevent the oxygen-carrying hemoglobin from the oxidation damage during the circulation. This biomimetic engineering can accumulate in tumors, permit in situ efficient oxygen supply, and impose strong PDT efficacy toward the extremely hypoxic tumor with complete tumor elimination. The man-made pseudo-RBC shows potentials as a universal oxygen-self-supplied platform to sensitize hypoxia-limited tumor treatment means, including but not limited to PDT. Meanwhile, this study offers ideas to the production of artificial substitutes of packed RBCs for clinical blood transfusion.

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“…The second category consists of polymers that undergo backbone breakdown by cleavage of bonds sensitive to ROS . In addition to their potential of targeting and on‐demand drug delivery, if ROS molecules are “consumed” in the reaction, these systems can also be explored for their ability to scavenge the excessively generated ROS and return ROS levels to normal levels …”

Section: Ros‐responsive Materialsmentioning

confidence: 99%

Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting

et al. 2019

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The pharmacological therapy for gastrointestinal (GI) diseases, such as inflammatory bowel diseases, continues to present challenges in targeting efficacy. The need for maximal local drug exposure at the inflamed regions of the GI tract has led research to focus on a disease-targeted drug delivery approach. Smart nanomaterials responsive to the reactive oxygen species (ROS) concentrated in the inflamed areas, can be formulated into nanoplatforms to selectively release the active compounds, avoiding unspecific drug delivery to healthy tissues and limiting systemic absorption. Recent developments of ROS-responsive nanoplatforms include combination with other materials to obtain multi-responsive systems and modifications/derivatization to increase the interactions with biological tissues, cell uptake and targeting. This review describes the applications of ROS-responsive nanosystems for on-demand drug delivery to the GI tract. K E Y W O R D Sgastrointestinal tract drug delivery, irritable bowel disease, oxidation-responsive materials, stimuli-responsive nanocarriers

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Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties

Cited by 88 publications

References 42 publications

Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers

Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers

Aggressive Man‐Made Red Blood Cells for Hypoxia‐Resistant Photodynamic Therapy

Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting

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