Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis

Guo, Xiaobin; Bai, Jiaxiang; Ge, Gaoran; Wang, Zhidong; Wang, Qing; Zheng, Kai; Tao, Huaqiang; Zhang, Lirong; Wang, Dongqing; Zhang, Xiaogang; Li, Hongxia; Pan, Guoqing

doi:10.1016/j.jcis.2021.07.079

Cited by 34 publications

(18 citation statements)

References 71 publications

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“…Recruitment and adhesion of BMSCs play vital roles in the initial peri-implant bone regeneration phase, which can significantly affect the subsequent bone healing process and implant osseointegration. , The cell adhesion fluorescent images of different samples at 1 h revealed that BMSCs on Ti, MTC-Ti, and nZnO-Ti were mostly spherical or elliptical (Figure A). In contrast, nZnO/MTC-Ti began to take on a polygonal shape and protruded abundant pseudopodia.…”

Section: Resultsmentioning

confidence: 99%

Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Wen¹,

Shi

Li³

et al. 2023

ACS Appl. Mater. Interfaces

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Two major issues are currently hindering the clinical practice of titanium dental implants for the lack of biological activities: immediate/early loading risks and peri-implantitis. To solve these issues, it is urgent to develop multifunctional implants modified with effective osteogenic and antibacterial properties. Zinc oxide nanoparticles (ZnO NPs) possess superior antibacterial activity; however, they can rapidly release Zn2+, causing cytotoxicity. In this study, a potential dental implant modification was creatively developed as ZnO nanoparticle-loaded mesoporous TiO2 coatings (nZnO/MTC-Ti) via the evaporation-induced self-assembly method (EISA) and one-step spin coating. The mesoporous TiO2 coatings (MTCs) regulated the synthesis and loading of ZnO NPs inside the nanosized pores. The synergistic effects of MTC and ZnO NPs on nZnO/MTC-Ti not only controlled the long-term steady-state release of Zn2+ but also optimized the charge distribution on the surface. Therefore, the cytotoxicity of ZnO NPs was resolved without triggering excessive reactive oxygen species (ROS). The increased extracellular Zn2+ further promoted a favorable intracellular zinc ion microenvironment through the modulation of zinc transporters (ZIP1 and ZnT1). Owing to that, the adhesion, proliferation, and osteogenic activity of bone mesenchymal stem cells (BMSCs) were improved. Additionally, nZnO/MTC-Ti inhibited the proliferation of oral pathogens (Pg and Aa) by inducing bacterial ROS production. For in vivo experiments, different implants were implanted into the alveolar fossa of Sprague–Dawley rats immediately after tooth extraction. The nZnO/MTC-Ti implants were found to possess a higher capability for enhancing bone regeneration, antibiosis, and osseointegration in vivo. These findings suggested the outstanding performance of nZnO/MTC-Ti implants in accelerating osseointegration and inhibiting bacterial infection, indicating a huge potential for solving immediate/early loading risks and peri-implantitis of dental implants.

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Section: Resultsmentioning

confidence: 99%

Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Wen¹,

Shi

Li³

et al. 2023

ACS Appl. Mater. Interfaces

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“…Previous pathological studies revealed severe inflammatory reactions around failed orthopedic implants [ 26 , 27 ]. Unstable internal fixation inevitably causes long-term tissue damage, which leads to a continuous progression of inflammation [ 28 ]. This will eventually lead to increased osteoclast production and overactivation [ 29 ], inducing the development of bone resorption around the internal fixation.…”

Section: Discussionmentioning

confidence: 99%

Nine-year-long complex humeral nonunion salvaged by distraction osteogenesis technique: a case report and review of the literature

et al. 2022

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Background Humeral nonunion with significant bone loss or shortening is uncommon and poses a complex clinical problem. We present a case of humeral nonunion with a large segmental bone defect treated with the distraction osteogenesis technique and remedy the radial nerve palsy produced during distraction osteogenesis by forearm tendon transfers. The reconstruction of upper limb function was achieved with satisfactory results. This case provides a referenceable alternative method for repairing large segmental bone defects due to complex nonunion of the upper extremity, as well as a remedy in the unfortunate event of radial nerve palsy, providing a reference and lessons learned for the treatment of similar cases and the management of possible complications. Case presentation A 31-year-old male patient experienced 9 years of hypertrophic nonunion due to an unreliable internal fixation. The radiographs showed the absence of bone bridging between the two fragments, loosening of the screws, and extensive osteolysis around the internal screws. The patient was treated with distraction osteogenesis. At the end of the distraction period, the patient unfortunately developed right radial nerve paresis, which was salvaged by forearm tendon transplantation, and finally reconstructed hand function and achieved bone union of the humerus. Conclusion Distraction osteogenesis, although not a panacea for all humeral nonunions with significant segmental bone loss, does offer a viable salvage procedure in this unusual and often complex clinical problem. When irreversible radial nerve palsy occurs during distraction, forearm tendon transfers can have a good clinical effect.

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“…On the other hand, M2-like sub-phenotypes are responsible for triggering tissue repair and are considered as an alternatively activated cell type, which secretes cytokines like IL-10 and IL1ra and chemokines like osteopontin (OPN). Although the entire ranges of different types of macrophages are necessary for healing resolution [ 57 ], M2-like macrophages are anti-inflammatory and facilitate wound healing, while M1-like macrophages accelerate osteolysis and implant loosening [ 63 , 64 ]. For example, numerous amounts of CD68 + macrophages (chiefly expressed by M1-like macrophages) are present at the implant site in patients with aseptic loosening.…”

Section: Immune Interaction and Gene Profile In Peri-implant Tissuesmentioning

confidence: 99%

Immune response differences in degradable and non-degradable alloy implants

Khodaei

Schmitzer

Suresh

et al. 2023

Bioactive Materials

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Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis

Cited by 34 publications

References 71 publications

Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Nine-year-long complex humeral nonunion salvaged by distraction osteogenesis technique: a case report and review of the literature

Immune response differences in degradable and non-degradable alloy implants

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Bioinspired peptide adhesion on Ti implants alleviates wear particle-induced inflammation and improves interfacial osteogenesis

Cited by 34 publications

References 71 publications

Mesoporous TiO2 Coatings Regulate ZnO Nanoparticle Loading and Zn2+ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Mesoporous TiO2 Coatings Regulate ZnO Nanoparticle Loading and Zn2+ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Nine-year-long complex humeral nonunion salvaged by distraction osteogenesis technique: a case report and review of the literature

Immune response differences in degradable and non-degradable alloy implants

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Product

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Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity