Bioinspired nanotopographical design of drug delivery systems

Finbloom, Joel A.; Huynh, Cindy; Huang, Xiao; Desai, Tejal A.

doi:10.1038/s44222-022-00010-8

Cited by 33 publications

(23 citation statements)

References 171 publications

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“…Colloidal gels could also incorporate new drug delivery methods that capitalize on spatial control. For instance, the nanotopographical design of a biointerface has shown new functionality for drug delivery, including improved bioadhesion, targeted cellular uptake, and increased drug distribution . This drug delivery technique could be combined with colloidal gels, which could improve the spatial control of the nanotopographical drug release.…”

Section: Discussionmentioning

confidence: 99%

Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications

Li,

Huberman-Shlaes,

Tian

2023

Langmuir

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Colloid-based materials with tunable biophysical and chemical properties have demonstrated significant potential in a wide range of biomedical applications. The ability to manipulate these properties across various size scales, encompassing nano-, micro-, and macrodomains, is essential to enhancing current biomedical technologies and facilitating the development of novel applications. Focusing on material design, we explore various synthetic colloid-based materials at the nano- and microscales and investigate their correlation with biological systems. Furthermore, we examine the utilization of the self-assembly of colloids to construct monolithic and macroscopic materials suitable for biointerfaces. By probing the potential of spatial imaging and localized drug delivery, enhanced functionality, and colloidal manipulation, we highlight emerging opportunities that could significantly advance the field of colloid-based materials in biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications

Li,

Huberman-Shlaes,

Tian

2023

Langmuir

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“…This effect might be due to the spiky and rough surfaces on VSNP, which have similar nanotopographical features to pollen-inspired particles and lead to the enhancement of bio-adhesion including the penetration of mucosal surfaces. 57,58 The detailed mechanism of the degree of surface roughness and the long term effect of these particles will be determined in the future study.…”

Section: In Vivo Assessment Of Gut Permeabilitymentioning

confidence: 99%

Virus-like silica nanoparticles enhance macromolecule permeationin vivo

Cao,

Janjua,

et al. 2023

Biomater. Sci.

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“…Precise control of surface topography especially in the nanoscale range is one of the important factors to improve the functionality both in biological activity and catalysis (61)(62)(63). As a proof of concept, we studied the effect of controllable nanotopography in silica nanoparticles on DNA transfection performance.…”

Section: The Implication Of the Hsa Approachmentioning

confidence: 99%

A hierarchical spatial assembly approach of silica-polymer composites leads to versatile silica/carbon nanoparticles

Cheng,

Zhang,

et al. 2023

Sci. Adv.

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Assembly of silica and polymer in the absence of surfactant templates is an emerging strategy to construct intricate nanostructures, whereas the underlying mechanism and structural versatility remain largely unexplored. We report a hierarchical spatial assembly strategy of silica-polymer composites to produce silica and carbon nanoparticles with unprecedented structures. The assembly hierarchy involves a higher length scale asymmetric A-B-A core-shell–type spatial assembly in a composite sphere, and a nanoscale assembly in the middle layer B in which the silica/polymer ratio governs the assembled structures of silica nanodomains. Through an in-depth understanding of the hierarchical spatial assembly mechanism, a series of silica and carbon nanoparticles with intriguing and controllable architectures are obtained that cannot be easily achieved via conventional surfactant-templating approaches. This work opens an avenue toward the designed synthesis of nanoparticles with precisely regulated structures.

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Bioinspired nanotopographical design of drug delivery systems

Cited by 33 publications

References 171 publications

Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications

Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications

Virus-like silica nanoparticles enhance macromolecule permeationin vivo

A hierarchical spatial assembly approach of silica-polymer composites leads to versatile silica/carbon nanoparticles

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