Bioinspired nanoplatelets for chemo-photothermal therapy of breast cancer metastasis inhibition

Platelet mediated TRAIL delivery for efficiently targeting circulating tumor cells

“…These platelet-like particles reduce the metastatic burden in in vivo mouse models. [15][16][17] Moreover, recent studies suggest that functionalizing platelet membranes with cytotoxic drugs is more efficient in killing CTCs and reducing cancer metastasis than loading the cytotoxic drug into the platelets. [18][19][20] While coagulation is understood to be generally pro-metastatic, in these platelet-based delivery approaches care is usually taken to ensure that normal hemostatic function is not disrupted.…”

Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition: Interfering with the crosstalk between “seed and soil”

“…Fortunately, various novel targeting tools as well as nanovehicles have been introduced to broaden the arsenal fighting against CTCs by virtue of advanced molecular and biomedical engineering technology. These nanosystems showed excellent CTC-targeting ability ( Table 2 41 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 ).…”

“… Nanocarriers Modification Payload Strategy Ref. Magnetic nanocore with multiple iron oxide nanoparticles Gold nanocage satellites and anti-epithelial cell adhesion molecule None Isolate CTCs by magnetic enrichment and eradicate CTCs 118 Dextran-octadecanoic acid micelles Sialic acid Doxorubicin E-selectin mediated targeted clearance 119 Peptide-based nanoparticle Cyclic RGD peptide and pH-sensitive polyhistidine sequence siRNA Down-regulate TF expression and prevent platelet adhesion around CTCs 120 PLGA nanoparticle Platelet membrane coating Doxorubicin and indocyanine green Capture and destroy CTCs 121 LMWH-TOS micellar nanoparticle Phenylboronic acid Doxorubicin Inhibit the interactions between tumor cells and platelets 41 Dendrimer G4.5 Two double strand circular aptamers None Apoptosize CTCs and inhibit their bioenergetic activities 122 Mesoporous silica nanoparticle Two aptamers Doxorubicin Inhibit CTCs viability and the adhesion of cancer cells to the endothelium and the consequent transmembrane migration 123 Polymer nanoparticle K237 peptide and Ep23 aptamer Paclitaxel Capture and neutralize CTCs in bloodstream 124 DNA tetrahedron Hairpin switch aptamer Doxorubicin and photosensitizer Destroy CTCs 125 Nanoparticle CD44v6-peptide CdTe quantum dots Bind to CD44v6 expressing tumor cells, block the function of CD44v6 protein and visualize CTCs 126 …”

Development of MOF “Armor‐Plated” Phycocyanin and Synergistic Inhibition of Cellular Respiration for Hypoxic Photodynamic Therapy in Patient‐Derived Xenograft Models

“…However, as these PS compound are prone to photobleaching, are costly to produce and implement, and are generally hydrophobic, their clinical utility to date is very limited. [ 6–11 ] In contrast to these agents, the pigment‐protein complex phycocyanin (PC), which can be derived from Spirulina sourced from Cyanophyta , Rhodophyta , or Crytophyta , contains blue phycocyanobilin (PCB) chromophores in the form of an open‐chain tetrapyrrole prosthetic group. In prior studies, PC has been shown to facilitate tumor‐associated macrophage (TAM)‐targeted photosensitization in the context of PDT treatment, making it a promising PS agent for use in the treatment of cancer given that it is water‐soluble, highly biocompatible, exhibits a high quantum fluorescent yield, and is associated with few side effects.…”