Bioinspired liquid gating membrane-based catheter with anticoagulation and positionally drug release properties

Abstract

Catheters are indispensable medical devices that are extensively used in daily medical treatment. However, existing catheter materials continue to encounter many problems, such as thrombosis, single functionality, and inadaptability to environmental changes. Inspired by blood vessels, we develop a self-adaptive liquid gating membrane-based catheter with anticoagulation and positionally drug release properties. Our multifunctional liquid gating membrane-based catheter significantly attenuates blood clot formation and can be used as a general catheter design strategy to offer various drugs positionally releasing applications to comprehensively enhance the safety, functionality, and performance of medical catheters’ materials.

Reconfiguring confined magnetic colloids with tunable fluid transport behavior

“…Without the magnetic field, the colloids are randomly distributed in the confined space, with the entropy of S r . When the immiscible fluid is transported through the confined colloids, a distinct pressure threshold is required to conquer the capillary force [ 23–26 , 35 ], denoted as P r . In state i, under a magnetic field that is parallel to the transport flow, the confined colloids could form chain structures along the magnetic direction, during which the entropy of the colloids is reduced ( S i < S r ).…”

Catalytic confinement effects in nanochannels: from biological synthesis to chemical engineering

“…Learning from nature is one of the most promising ways to address such issues. 61–65 In terms of the outstanding properties of reactions in biological systems previously mentioned, scientists are inspired by biosynthesis in nature and then design nanochannels to achieve much higher chemical reaction rate and better selectivity. 66–68 However, the nanotechnology of fabricating various nanochannels is accelerating the research on the exploration of mass transport, and unique physical and chemical properties in nanochannels.…”

Progress in bio-inspired porous membranes

“…针对传统医用导管存在的功能性单一、无响应性 差、抗凝血性能差等问题. 本课题组 [70] 基于仿生液门 复合控多孔膜技术开发出具有优异血液相容性的液体 复合门控多孔膜基医用导管(图8(a1)). 该膜主要是由…”

“…(a1) Schematic diagram of liquid gating membrane-based catheter. (a2) Tube sizes, anticoagulation property and drug release of the membrane[70]…”