Bioinspired lipid-polysaccharide modified hybrid nanoparticles as a brain-targeted highly loaded carrier for a hydrophilic drug

Omar, Sara Hassan; Osman, Rihab; Mamdouh, Wael; Abdel-Bar, Hend Mohamed; Awad, Gehanne A.S.

doi:10.1016/j.ijbiomac.2020.09.170

Cited by 21 publications

(9 citation statements)

References 47 publications

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“…High levels of the antimicrobial agent are used to cover the nanoparticles. These studies suggest that nanoparticles of maleic acid will penetrate the brain to give a new, more efficient protein product [51]. Nanoparticle delivery of drugs could prevent symptoms of Alzheimer's.…”

Section: Lipid Nanoparticles Effects On Amyloid Beta Peptidementioning

confidence: 99%

Potential Role of Nanoparticles in Treating the Accumulation of Amyloid-Beta Peptide in Alzheimer’s Patients

Abbas

2021

Polymers

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The disorder of Alzheimer’s is marked by progressive pathophysiological neurodegeneration. The amino acid peptides in the amyloid plaques found in the brains of people with Alzheimer’s disease (AD) are known as amyloid-beta (Aβ). Current treatments are not curative, and the effects associated with AD are reduced. Improving treatment results involved the targeting of drugs at optimum therapeutic concentration. Nanotechnology is seen as an unconventional, modern technology that plays a key role in the treatment of Alzheimer’s disease. Using nanoparticles, molecular detection, effective drug targeting, and their combination offer high sensitivity. The aim of this review is to shed light on the function and successful role of nanoparticles to resolve Aβ aggregation and thus to help cure Alzheimer’s disease. The analysis divides these nanoparticles into three categories: polymer, lipid, and gold nanoparticles. A thorough comparison was then made between the nanoparticles, which are used according to their role, properties, and size in the procedure. The nanoparticles can prevent the accumulation of Aβ during the efficient delivery of the drug to the cells to treat Alzheimer’s disease. Furthermore, this comparison demonstrated the ability of these nanoparticles to deal efficiently with Alzheimer’s disease. The role of these nanoparticles varied from delivering the drug to brain cells to dealing with the disease-causing peptide.

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Section: Lipid Nanoparticles Effects On Amyloid Beta Peptidementioning

confidence: 99%

Potential Role of Nanoparticles in Treating the Accumulation of Amyloid-Beta Peptide in Alzheimer’s Patients

Abbas

2021

Polymers

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“…Lipid–polysaccharide surface-modified hybrid NPs were reported by Omar et al [ 117 ] using the nanoprecipitation method for the brain delivery of rivastigmine (Riv). Dextros-cholic acid (DxC) was used as a polysaccharide for the surface modification of lipid–PLGA NPs.…”

Section: Surface Functionalization Of Lphnpsmentioning

confidence: 99%

Lipid–Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery

Jain,

Kumar,

Kumar

et al. 2023

JFB

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Lipid nanoparticles (LNPs) are spherical vesicles composed of ionizable lipids that are neutral at physiological pH. Despite their benefits, unmodified LNP drug delivery systems have substantial drawbacks, including a lack of targeted selectivity, a short blood circulation period, and in vivo instability. lipid–polymer hybrid nanoparticles (LPHNPs) are the next generation of nanoparticles, having the combined benefits of polymeric nanoparticles and liposomes. LPHNPs are being prepared from both natural and synthetic polymers with various techniques, including one- or two-step methods, emulsification solvent evaporation (ESE) method, and the nanoprecipitation method. Varieties of LPHNPs, including monolithic hybrid nanoparticles, core–shell nanoparticles, hollow core–shell nanoparticles, biomimetic lipid–polymer hybrid nanoparticles, and polymer-caged liposomes, have been investigated for various drug delivery applications. However, core–shell nanoparticles having a polymeric core surrounded by a highly biocompatible lipid shell are the most commonly explored LPHNPs for the treatment of various diseases. In this review, we will shed light on the composition, methods of preparation, classification, surface functionalization, release mechanism, advantages and disadvantages, patents, and clinical trials of LPHNPs, with an emphasis on core–shell-structured LPHNPs.

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“…Simultaneously with the continuous stirring of the reaction mixture with a magnetic stirrer [47,48], vortex [49,50], or bath sonication [51,52], the organic solvent is evaporated by gentle heating, which triggers the solidification of the oily materials in the solution. Finally, the CSHNs are collected and purified by dialysis [47], ultrafiltration [53], or ultracentrifugation [48,50]. Regarding the experimental details, it should be noted that some key parameters (e.g., the optimal reaction time and temperature) are largely case-dependent and therefore cannot be generalized according to the relevant literature.…”

Section: Modified Nanoprecipitation Techniquementioning

confidence: 99%

Section: Modified Nanoprecipitation Techniquementioning

confidence: 99%

The state of the art in core-shell type lipid polymer hybrid nanocarriers and beyond

Sengel-Türk

Alptürk

2022

Preprint

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The need to enhance the therapeutic effect of drugs and thus reduce their side effects is the reason for the emergence of today's drug delivery systems. With the advent of nanotechnology, numerous molecular structures - from carbon nanotubes to polymeric materials - have been developed, and significant progress has been made. However, all these promising results do not mean that drug delivery systems are a solution to all problems in pharmaceutical technology. This is because any drug delivery system, while having its advantages, also suffers from certain limitations. Therefore, new and hybrid structures are created by combining different materials. In this respect, lipid-polymer hybrid particles emerged as a core-shell structure, where the polymer core is covered with a layer of phospholipids, and have attracted attention in the academic community. This manuscript, which provides an overview of the fundamentals of these molecular architectures, begins with a description of lipid-polymer hybrid particles. Conventional and unconventional production methods for fabricating these structures are then described. This is followed by a section discussing how the physical properties of these particles are characterized and how the physical properties affect pharmaceutical activity. The final section discusses prominent examples from the literature.

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Bioinspired lipid-polysaccharide modified hybrid nanoparticles as a brain-targeted highly loaded carrier for a hydrophilic drug

Cited by 21 publications

References 47 publications

Potential Role of Nanoparticles in Treating the Accumulation of Amyloid-Beta Peptide in Alzheimer’s Patients

Potential Role of Nanoparticles in Treating the Accumulation of Amyloid-Beta Peptide in Alzheimer’s Patients

Lipid–Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery

The state of the art in core-shell type lipid polymer hybrid nanocarriers and beyond

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