Bioinspired Injectable Polyurethane Underwater Adhesive with Fast Bonding and Hemostatic Properties

Guo, Xiaolei; Zhao, Xin; Yuan, Lei; Ming, Hao; Li, Zhen; Li, Jiehua; Luo, Feng; Tan, Hong

doi:10.1002/advs.202308538

Cited by 4 publications

(3 citation statements)

References 55 publications

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“…Furthermore, both MXene/Que-WPU and Que-WPU exhibited excellent blood compatibility. The cytocompatibility of the film patches is essential for wound healing . It was evaluated via an in vitro MTT antitumor bioassay using HaCaT cells (Figure S5).…”

Section: Resultsmentioning

confidence: 99%

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Flexible Wound Patches Based on MXene/Quercetin-Waterborne Polyurethane Composites

Wang,

Yan,

et al. 2024

ACS Appl. Nano Mater.

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Traditional wound patches are primarily designed to provide protection, maintain moisture, and foster a healing environment. However, current flexible wound patches face challenges related to self-healing capabilities, antimicrobial performance, and stable sensing functions. To address these challenges, this study harnesses the synergistic potential of aqueous MXene nanosheets and quercetin-modified waterborne polyurethane (Que-WPU) to fabricate an innovative film patch. The film patch exhibits stable adhesion to human skin and shows significant inhibitory effects on Staphylococcus aureus due to the natural antibacterial agent quercetin, with a zone of inhibition that reaches 4 mm. Furthermore, the antibacterial efficiency is further enhanced to 100% because of the excellent photothermal properties of MXene under near-infrared laser irradiation. Meanwhile, the film patch possesses stable scavenging activity against DPPH and ABTS + free radicals and exhibits good blood compatibility and cytocompatibility with an in vitro hemolysis rate of 4.7% and negligible toxicity to HaCaT cells. It also displays a robust self-healing performance, completely repairing scratches within 2 min. Additionally, the film patch can detect clear and stable sensing signals under continuous human body part movement cycles, with sensing sensitivity (Gauge Factor) of 2.1. In summary, these results underscore the immense potential of MXene/Que-WPU composite materials in wound healing and tissue engineering applications.

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Section: Resultsmentioning

confidence: 99%

“…The cytocompatibility of the film patches is essential for wound healing. 39 It was evaluated via an in vitro MTT antitumor bioassay using HaCaT cells (Figure S5). The results revealed that HaCaT cell viability (%) was above 93.39% in a concentration range of 0.50 mg/mL.…”

Section: In Vitro Hemolysis Assay Andmentioning

confidence: 99%

Flexible Wound Patches Based on MXene/Quercetin-Waterborne Polyurethane Composites

Wang,

Yan,

et al. 2024

ACS Appl. Nano Mater.

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“…28–32 Among the various hydrogels, polyurethane-based hydrogels have exhibited exceptional performance. 32–36 Recently, hydrogels exhibited great potential for postoperative anti-adhesions. Particularly, physical isolation that involves the obstruction of contact between the surgical site and its surrounding tissue is convenient for injectable hydrogels.…”

Section: Introductionmentioning

confidence: 99%

A bioinspired injectable antioxidant hydrogel for prevention of postoperative adhesion

Yuan,

Wei,

Pan

et al. 2024

J. Mater. Chem. B

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High‐Performance Dopamine‐Based Supramolecular Bio‐Adhesives

Hagemann,

Chadwick,

Drake

et al. 2024

Macromol. Rapid Commun.

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The need for wound closure or surgical procedures has been commonly met by application of sutures. Unfortunately, these are often invasive or subject to contamination (and consequent infection and negative impact on patients). Alternative solutions are offered by surgical adhesives that can be applied and set without major disruption; a new class of supramolecular‐based adhesives provide potential solutions to some of these challenges. In this study a series of polymers utilising dopamine as a self‐assembling unit were synthesized. It was found that these motifs act as extremely effective adhesives, with control over the mechanical strength of the adhesion and materials’ tensile properties enabled by changing monomer feed ratios and levels of crosslinking. These materials significantly outperform commercially available bio‐adhesives, showing yield strengths after adhesion at least 2 times higher than that of BioGlue and Tisseel, as well as the ability to re‐adhere with significant recovery of adhesion strength. Promisingly, the materials were shown to be non‐cytotoxic, with cell viability > 90%, and able to perform in aqueous environments without significant loss in strength. Finally, the removal of the materials, after use as an adhesive, was possible using benign organic solvents such as ethanol, ensuring recyclability. These properties all demonstrate the effectiveness of the materials as potential bio‐adhesives, with potential advantages for use in surgery.This article is protected by copyright. All rights reserved

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Bioinspired Injectable Polyurethane Underwater Adhesive with Fast Bonding and Hemostatic Properties

Cited by 4 publications

References 55 publications

Flexible Wound Patches Based on MXene/Quercetin-Waterborne Polyurethane Composites

Flexible Wound Patches Based on MXene/Quercetin-Waterborne Polyurethane Composites

A bioinspired injectable antioxidant hydrogel for prevention of postoperative adhesion

High‐Performance Dopamine‐Based Supramolecular Bio‐Adhesives

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