Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing

Du, Shuo; Zhou, Nan; Gao, Yujie; Xie, Ge; Du, Hui; Jiang, Hao; Zhang, Lianbin; Tao, Juan; Zhu, Jintao

doi:10.1007/s12274-020-2891-9

Cited by 99 publications

(64 citation statements)

References 52 publications

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“…skin [17,78] hand [18,37,76] skin underneath [88,92] skin underneath [104] hand [26,33,38,44,53,65] skin [79] Biomechanical Energy Source walking, running [42,53,56,69,80] walking, running [32,48,77] joint movement [99] motions of leg [104] stretching [21,25,26,33,53,56] stretching [29,72] [ 76,79] blood pressure [93] blood pressure [112,119] blinking [23,28] joint movement [49,50,81] the peristalsis of duodenum [120] motions of stomach [103] shake and pat [17,38,43,82] breathing…”

Section: Location Of Installationmentioning

confidence: 99%

“…Applications human-machine interface [20,55] motion monitoring [19,29,37,50] anti-bacteria [99] in vivo health monitoring [83,97,119] motion monitoring [21,27,33,56,74] health monitoring [18,49,52] anti-tumor therapy [94] in vivo therapying [29,103,104,114] health monitoring [27,45,78] wound healing [79] in vivo health monitoring [101,105,120] regeneration of tissues [85] eye motion monitoring [23,28] power supply [18,32,72,77] electrical stimulator [98] implanted sensor [112] voice and gesture recognition [20,44,65] power supply [87,88,92,93] power supply [84,106,…”

Section: Location Of Installationmentioning

confidence: 99%

“…Jaegyu Kim et al developed a highly flexible fabric-based wearable PENG with high efficiency and strong integration [72], as shown in Figure 7f. Beyond these, Shu Du et al developed a bio-inspired hybrid patch with a PENG embedded [79]. The PENG is employed as an electrical stimulator to facilitate skin wound healing.…”

Section: Self-powered Wearable Systems Based On Pengmentioning

confidence: 99%

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Progress on Self-Powered Wearable and Implantable Systems Driven by Nanogenerators

Yang

Tian

et al. 2021

Micromachines

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With the rapid development of the internet of things (IoT), sustainable self-powered wireless sensory systems and diverse wearable and implantable electronic devices have surged recently. Under such an opportunity, nanogenerators, which can convert continuous mechanical energy into usable electricity, have been regarded as one of the critical technologies for self-powered systems, based on the high sensitivity, flexibility, and biocompatibility of piezoelectric nanogenerators (PENGs) and triboelectric nanogenerators (TENGs). In this review, we have thoroughly analyzed the materials and structures of wearable and implantable PENGs and TENGs, aiming to make clear how to tailor a self-power system into specific applications. The advantages in TENG and PENG are taken to effectuate wearable and implantable human-oriented applications, such as self-charging power packages, physiological and kinematic monitoring, in vivo and in vitro healing, and electrical stimulation. This review comprehensively elucidates the recent advances and future outlook regarding the human body’s self-powered systems.

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Section: Location Of Installationmentioning

confidence: 99%

Section: Location Of Installationmentioning

confidence: 99%

Section: Self-powered Wearable Systems Based On Pengmentioning

confidence: 99%

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Progress on Self-Powered Wearable and Implantable Systems Driven by Nanogenerators

Yang

Tian

et al. 2021

Micromachines

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show abstract

“…Due to the higher electronegativity of fluorine (F) compared to carbon (C) and hydrogen (H) in polyvinylidene fluoride (PVDF), which is the most electrically active piezoelectric polymer [ 12 ], and its copolymers with tetra-(TeFE) and trifluoroethylene (TrFE), a certain conformation of macromolecules results in a dipole moment in a polymer chain directed perpendicular to its axis. Currently, the application of PVDF elecrospun scaffolds as a wound healing material is being actively studied [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Composite Ferroelectric Membranes Based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing

et al. 2020

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Wound healing is a complex process and an ongoing challenge for modern medicine. Herein, we present the results of study of structure and properties of ferroelectric composite polymer membranes for wound healing. Membranes were fabricated by electrospinning from a solution of vinylidene fluoride/tetrafluoroethylene copolymer (VDF–TeFE) and polyvinylpyrrolidone (PVP) in dimethylformamide (DMF). The effects of the PVP content on the viscosity and conductivity of the spinning solution, DMF concentration, chemical composition, crystal structure, and conformation of VDF–TeFE macromolecules in the fabricated materials were studied. It was found that as PVP amount increased, the viscosity and conductivity of the spinning solutions decreased, resulting in thinner fibers. Using FTIR and XRD methods, it was shown that if the PVP content was lower than 50 wt %, the VDF–TeFE copolymer adopted a flat zigzag conformation (TTT conformation) and crystalline phases with ferroelectric properties were formed. Gas chromatography results indicated that an increase in the PVP concentration led to a higher residual amount of DMF in the material, causing cytotoxic effects on 3T3L1 fibroblasts. In vivo studies demonstrated that compared to classical gauze dressings impregnated with a solution of an antibacterial agent, ferroelectric composite membranes with 15 wt % PVP provided better conditions for the healing of purulent wounds.

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“…Currently, the application of PVDF elecrospun scaffolds as a wound healing material is being actively studied [14][15][16][17].…”

mentioning

confidence: 99%

Composite Ferroelectric Membranes based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing: A Pilot Study

Tverdokhlebova¹,

Antipina²,

Kudryavtseva³

et al. 2020

Preprint

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Herein, we report results of the study of the composite ferroelectric scaffolds based on vinylidene fluoride-tetrafluoroethylene copolymer (VDF-TeFE) and polyvinylpyrrolidone (PVP) produced by electrospinning and their application as a wound-healing material. The physicochemical properties of ferroelectric composite polymer scaffolds depending on the content of PVP (in the range from 0 to 50 wt %) including morphology, composition and crystalline structure were studied. The cytotoxicity of materials and the proliferative activity of cells during their cultivation on the surface of formed scaffolds are reported. It has been found that the optimal PVP content in the VDF-TeFE composite scaffolds is 15 wt%. On a model of a full-thickness contaminated wound in vivo, it was shown that piezoelectric scaffolds based on VDF-TeFE copolymer containing 15 wt% PVP provide better wound healing results in comparison with standard gauze dressings impregnated with a solution of an antibacterial agent.

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Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing

Cited by 99 publications

References 52 publications

Progress on Self-Powered Wearable and Implantable Systems Driven by Nanogenerators

Progress on Self-Powered Wearable and Implantable Systems Driven by Nanogenerators

Composite Ferroelectric Membranes Based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing

Composite Ferroelectric Membranes based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing: A Pilot Study

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