Abstract:The protein FKBP52
is a steroid hormone receptor coactivator likely
involved in neurodegenerative disease. A series of small, water-soluble,
bioinspired, pseudopeptidic fluorescent ligands for the FK1 domain
of this protein are described. The design is such that engulfing of
the ligand in the pocket of this domain is accompanied by hydrogen-bonding
of the dansyl chromophore which functions as both an integral part
of the ligand and a fluorescent reporter. Binding is concomitant with
a significant wavelength sh… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.