Bioinspired complexes confined in well-defined capsules: getting closer to metalloenzyme functionalities

Abstract

Reproducing the key features offers by metalloprotein binding cavities is an attractive approach to overcome the main bottlenecks of curent open artificial models (in terms of stability, efficiency and selectivity)....

Cage-based sensors for circular dichroism analysis

“…Covalent cages do not contain metals and bind covalently with ligands, in contrast to metallacages and their noncovalent cage-analyte interactions. 47–49 Because some chiral analytes are unstable in the presence of metal ions and others contain metal ions themselves, the metal-free cages have an important place in chiral sensing. This section compiles the latest examples of covalent cages for the detection of chiral analytes, including ions, small molecules, and peptides.…”

Light-Induced Reactivity Switch at O2–Activating Bioinspired Copper(I) Complexes

“…We derivatized the archetypal TPA scaffold by installing one aryl ether MeO PhO−CH 2 − unit onto the 6-position of the TPA's pyridine moieties to give the open ligand L 1 . A related cage HmTPA, recently studied in our group as Fe-ligand for selective oxidation of methane, 39,40 was also investigated featuring a single isolated copper-binding site (Figure 2…”

“…We derivatized the archetypal TPA scaffold by installing one aryl ether MeO PhO–CH 2 – unit onto the 6-position of the TPA ’s pyridine moieties to give the open ligand L 1 . A related cage HmTPA , recently studied in our group as Fe-ligand for selective oxidation of methane, , was also investigated featuring a single isolated copper-binding site (Figure ). Interestingly, oxygenation studies on the new, open, and caged complexes Cu I ( L 1 ) + and Cu I ( HmTPA ) + , revealed a photoinduced [1,3]-shift rearrangement involving a C–O bond cleavage and the formation of a new C–C bond with the resulting phenolate unit.…”

Molecular vessels from preorganised natural building blocks

“…11–15 The field has developed rapidly in recent years, accompanied by an increasing understanding of the effects of spatial confinements on the thermodynamic and kinetic properties of guest molecules. 16,17 All these factors stimulated development in the field and the search for new supramolecular vessels with pre-programmed functionalities.…”