Bioinspired aligned wrinkling dressings for monitoring joint motion and promoting joint wound healing

Zhou, Xiaohui; Feng, Pingping; Liu, Huanliang; Song, Botao

doi:10.1039/d2bm00602b

Cited by 10 publications

(14 citation statements)

References 35 publications

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“…Patients undergoing joint wound recovery, especially those who just had a joint surgery, such as total joint replacement, need to have regular exercise according to scientific reports. Wound dressings with a motion-monitoring function can help doctors notice the joint status of patients in real time, and it is convenient for them to intervene effectively when necessary …”

Section: Resultsmentioning

confidence: 99%

“…Wound dressings with a motion-monitoring function can help doctors notice the joint status of patients in real time, and it is convenient for them to intervene effectively when necessary. 20 The key to the motion-monitoring function is that the dressings need to be conductive. For our helical fiber composite membrane design, conductive silver nanoparticles could be conveniently introduced into the fibers, thus achieving electrical conductivity of the entire dressing along the fibers' axis direction.…”

Section: Motion-monitoring Ability Of the Composite Membranesmentioning

confidence: 99%

“…Song et al achieved good electrical conductivity by preparing Ag-modified hydrophilic− hydrophobic Janus nanofibrous membranes as well as stretchability by shrinking the nanofibrous membranes through water-induced self-assembly. 20 However, the tensile strength of the membranes made by this method was relatively high and the stretchability was not satisfying enough either, which may affect comfort when worn. Wang et al obtained BCD/PDA/PAM hydrogels by grafting, which simultaneously achieved high stretchability, viscoelasticity, and antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

“…The requirement of functionalization also limits the choice of dressing materials. For example, the antibacterial function requires the dressing to have special bactericidal groups or the ability to load drugs (usually accompanied by a dense network structure and poor mechanical properties such as stretchability), and the motion sensing function usually requires the dressing to be conductive, which is also hard to achieve for common hydrogel materials. − Under the requirements of these properties, how to achieve a balance between different characteristics has become a difficult research point …”

Section: Introductionmentioning

confidence: 99%

“…However, the contact of Ag NPs with the skin may have potential toxic effects. Song et al achieved good electrical conductivity by preparing Ag-modified hydrophilic– hydrophobic Janus nanofibrous membranes as well as stretchability by shrinking the nanofibrous membranes through water-induced self-assembly . However, the tensile strength of the membranes made by this method was relatively high and the stretchability was not satisfying enough either, which may affect comfort when worn.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Bio-Inspired Low-Cost Fabrication of Stretchable, Adhesive, Transparent, and Multi-Functionalized Joint Wound Dressings

Ling

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Ideal joint wound dressings should not only promote wound healing and have good mechanical properties including stretchability and adhesion but also possess functions such as sterilization or motion monitoring. The multiple characteristic requirements have greatly limited the material’s alternative, resulting in research on functional joint wound dressings falling far short of market demand. Therefore, low-cost, comprehensive designs need to be developed. Herein, inspired by the spiral arteries in the endometrium, alginate-based helical fibers were introduced into polyacrylamide/gelatin (PAM-Gel) to obtain composite polymer membranes, realizing a combination of both mechanical and functional properties. Large scale (100 m) and high-throughput (10 times higher than literature) fabrication of helical microfibers were first achieved, ensuring the low cost of fiber preparation. The composite film had adequate stretchability (>300% strain), adhesion strength (14 kPa), high transparency, and good biocompatibility. The helical fibers could be easily functionalized without affecting the mechanical properties of the dressings, thus broadening the range of materials available for joint dressings. After different treatments of the helical fibers, controlled drug release and joint motion monitoring were realized. Therefore, this helical microfiber composite membrane design achieved low-cost preparation, good mechanical properties, and functionalities including healing promotion, drug release, and motion monitoring ability, demonstrating application potential.

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Section: Resultsmentioning

confidence: 99%

Section: Motion-monitoring Ability Of the Composite Membranesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bio-Inspired Low-Cost Fabrication of Stretchable, Adhesive, Transparent, and Multi-Functionalized Joint Wound Dressings

Ling

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Injectable Conductive Hydrogel with Self‐Healing, Motion Monitoring, and Bacteria Theranostics for Bioelectronic Wound Dressing

Shan,

Chen,

Zhang

et al. 2024

Adv Healthcare Materials

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Wounds at joints are difficult to treat and tend to recover more slowly due to the frequent motions. When using traditional hydrogel dressings, they are easy to crack and undergo bacterial infection, difficult to match and monitor the irregular wounds. Integrating multiple functions within a hydrogel dressing to achieve intelligent wound monitoring and healing remains a significant challenge. In this research, we develop a multifunctional hydrogel based on polysaccharide biopolymer, poly(vinyl alcohol), and hydroxylated graphene through dynamic borate ester bonding and supramolecular interaction. The prepared hydrogel not only exhibits rapid self‐healing (within 60 s), injectable, conductive and motion monitoring properties, but also realizes in situ bacterial sensing and killing functions. It shows excellent bacterial sensitivity (within 15 min) and killing ability via the changes of electrical signals and photothermal therapy, avoiding the emergence of drug‐resistant bacteria. In vivo experiments prove that the hydrogel can promote wound healing effectively. In addition, it displays great electromechanical performance to achieve real‐time monitoring and prevent re‐tearing of the wound at human joints. The injectable pH‐responsive hydrogel with good biocompatibility demonstrates considerable potential as multifunctional bioelectronic dressing for the detection, treatment, management and healing of infected joint wounds.This article is protected by copyright. All rights reserved

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Sprayable Zwitterionic Antibacterial Hydrogel With High Mechanical Resilience and Robust Adhesion for Joint Wound Treatment

Hu,

Du,

Bai

et al. 2024

Macromol. Rapid Commun.

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Wound healing in movable parts, including joints and neck, remains a critical challenge due to frequent motions and poor flexibility of dressings, which may lead to mismatching of mechanical properties and poor fitting between dressings and wounds, thus increasing the risk of bacterial infection. Hence, this study proposed a sprayable zwitterionic antibacterial hydrogel with outstanding flexibility and desirable adhesion. This hydrogel precursor was fabricated by combining zwitterionic sulfobetaine methacrylate (SBMA) with poly(sulfobetaine methacrylate‐co‐dopamine methacrylamide)‐modified silver nanoparticles (PSBDA@AgNPs) through robust electrostatic interactions. About 150 s of exposure to UV light, the SBMA monomer polymerized to form PSB chains entangled with PSBDA@AgNPs, which were transformed into a stable and adhesion PSB‐PSB@Ag hydrogel at the wound site. The resulting hydrogel had adhesive strength (15–38 kPa), large tensile strain (>400%), suitable shape adaptation and excellent mechanical resilience. Moreover, the hydrogel displayed pH‐responsive behavior, the acidic microenvironment at the infected wound sites prompted the hydrogel to rapidly release AgNPs and kill bacteria. Furthermore, the healing effect of the hydrogel was demonstrated on the rat neck skin wound, showing improved wound closing rate due to reduced inflammation and enhanced angiogenesis. Overall, the sprayable zwitterionic antibacterial hydrogel had significant potential to promote joint skin wound healing.This article is protected by copyright. All rights reserved

show abstract

Bioinspired aligned wrinkling dressings for monitoring joint motion and promoting joint wound healing

Abstract: Joint skin wounds are hard to treat due to the frequently large motion of these active wounds, thus dressings capable of simultaneously real-time monitoring joint motion and promoting joint wound...

Cited by 10 publications

References 35 publications

Bio-Inspired Low-Cost Fabrication of Stretchable, Adhesive, Transparent, and Multi-Functionalized Joint Wound Dressings

Bio-Inspired Low-Cost Fabrication of Stretchable, Adhesive, Transparent, and Multi-Functionalized Joint Wound Dressings

Injectable Conductive Hydrogel with Self‐Healing, Motion Monitoring, and Bacteria Theranostics for Bioelectronic Wound Dressing

Sprayable Zwitterionic Antibacterial Hydrogel With High Mechanical Resilience and Robust Adhesion for Joint Wound Treatment

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