Bioinspired adenine–dopamine immobilized polymer hydrogel adhesives for tissue engineering

Joshi, Saurabh; Mahadevan, Gomathi; Verma, Sandeep; Valiyaveettil, Suresh

doi:10.1039/d0cc04909c

Cited by 19 publications

(12 citation statements)

References 32 publications

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“…Joshi et al [ 58 ] reported the development of polyacrylic acid (PAA) and alginic acid (Alg) adhesive hydrogels for biomedical application. Unmodified PAA and Alg present interesting properties for the preparation of hydrogels, including ease of chemical modification, pH sensitivity, and capacity to retain water, which is nevertheless limited by poor adhesion.…”

Section: Resultsmentioning

confidence: 99%

Mussel-Inspired Catechol Functionalisation as a Strategy to Enhance Biomaterial Adhesion: A Systematic Review

et al. 2021

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Biomaterials have long been explored in regenerative medicine strategies for the repair or replacement of damaged organs and tissues, due to their biocompatibility, versatile physicochemical properties and tuneable mechanical cues capable of matching those of native tissues. However, poor adhesion under wet conditions (such as those found in tissues) has thus far limited their wider application. Indeed, despite its favourable physicochemical properties, facile gelation and biocompatibility, gellan gum (GG)-based hydrogels lack the tissue adhesiveness required for effective clinical use. Aiming at assessing whether substitution of GG by dopamine (DA) could be a suitable approach to overcome this problem, database searches were conducted on PubMed® and Embase® up to 2 March 2021, for studies using biomaterials covalently modified with a catechol-containing substituent conferring improved adhesion properties. In this regard, a total of 47 reports (out of 700 manuscripts, ~6.7%) were found to comply with the search/selection criteria, the majority of which (34/47, ~72%) were describing the modification of natural polymers, such as chitosan (11/47, ~23%) and hyaluronic acid (6/47, ~13%); conjugation of dopamine (as catechol “donor”) via carbodiimide coupling chemistry was also predominant. Importantly, modification with DA did not impact the biocompatibility and mechanical properties of the biomaterials and resulting hydrogels. Overall, there is ample evidence in the literature that the bioinspired substitution of polymers of natural and synthetic origin by DA or other catechol moieties greatly improves adhesion to biological tissues (and other inorganic surfaces).

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Section: Resultsmentioning

confidence: 99%

Mussel-Inspired Catechol Functionalisation as a Strategy to Enhance Biomaterial Adhesion: A Systematic Review

et al. 2021

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“…The hydrogels were prepared from modified formulae from Joshi et al [ 74 ]. The PAA amount was optimized to get the desired hydrogel properties ( Figure S2, Table S1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The PAA hydrogel formulation was adapted from Joshi et al [ 74 ]. For the preparation of hydrogels without milk, 150 mg of PAA was first dissolved in 2 mL of DI water or extract solution in DI water for 3–4 h. After the complete dissolution of PAA, 24.8 mg of MBA and 50 mg of APS were added.…”

Section: Methodsmentioning

confidence: 99%

Polymeric Hydrogels for Controlled Release of Black Tea and Coffee Extracts for Topical Applications

Makhija

Kathuria

Sethi

et al. 2021

Gels

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Tea and coffee are popular beverages. Both are also used in topical applications, such as ultraviolet (UV) protection, anti-aging, and wound healing. However, the impact of tea and coffee extract on skin cells is minimally explored. This study investigated the direct exposure of tea and coffee extract on skin cells using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. It was found that direct exposure of tea and coffee to skin cells can be toxic at a high dose on prolonged exposure (72 h). Therefore, it was hypothesized that a formulation providing a controlled release of tea and coffee could improve their skin compatibility. Thermally cross-linked poly(acrylic acid) hydrogels loaded with tea and coffee extracts (with and without milk) were formulated and optimized. The release profiles of these hydrogels were studied at varying loading efficiency. Milk addition with tea extract retarded the tea extract release from hydrogel while minimally affecting the coffee release. This effect was due to the molecular interaction of tea with milk components, showing changes in size, zeta potential, and polydispersity index. The release study best fitted the Korsmeyer–Peppas release model. Skin cells exposed to tea or coffee-loaded hydrogel showed normal skin cell morphology under fluorescence microscopic analysis. In conclusion, the hydrogels controlled the tea and coffee release and showed biocompatibility with skin cells. It can potentially be used for skin applications.

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“…As alginic acid and its derivatives have good stability, solubility and viscosity and are safe, they are often used as excipients for food or pharmaceutical preparations to achieve thickening, stability and emulsification [ 13 ]. However, recent studies have shown that alginic acid and its derivatives also have good biocompatibility, antioxidant activity and anti-inflammatory activity [ 14 , 15 , 16 , 17 ]. At present, they are mostly commonly applied in cosmetics, and there are various anti-wrinkle, moisturizing and anti-ultraviolet products available [ 6 ].…”

Section: Alginic Acid and Its Derivativesmentioning

confidence: 99%

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

et al. 2020

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In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed.

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Bioinspired adenine–dopamine immobilized polymer hydrogel adhesives for tissue engineering

Abstract: Nontoxic adhesive hydrogels are of great importance in tissue engineering. Herein, we report a simple synthesis of a few biocompatible hydrogels from adenine and dopamine immobilized polyacrylic acid (PAA) and...

Cited by 19 publications

References 32 publications

Mussel-Inspired Catechol Functionalisation as a Strategy to Enhance Biomaterial Adhesion: A Systematic Review

Mussel-Inspired Catechol Functionalisation as a Strategy to Enhance Biomaterial Adhesion: A Systematic Review

Polymeric Hydrogels for Controlled Release of Black Tea and Coffee Extracts for Topical Applications

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

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