Bioinorganic supplementation of calcium phosphate-based bone substitutes to improve<i>in vivo</i>performance: a systematic review and meta-analysis of animal studies

Lodoso‐Torrecilla, Irene; Gunnewiek, Raquel Klein; Grosfeld, Eline‐Claire; Vries, Rob B. M. de; Habibović, Pamela; Jansen, John A.; Beucken, Jeroen J.J.P. van den

doi:10.1039/d0bm00599a

Cited by 19 publications

(15 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CP cement can be classified into different groups with different stability and/or solubility: (1) HA and α-tricalcium phosphate (α-TCP); (2) BCP, and (3) DCPD and β-tricalcium phosphate (β-TCP) [ 28 ]. Table 1 lists the main calcium phosphate compounds used as bone substitutes and their Ca/P ratio [ 29 ] ( Table 1 ).…”

Section: Calcium Compoundsmentioning

confidence: 99%

“…A recent meta-analysis of in-vitro studies reported that strontium, magnesium, and silica significantly enhanced new bone formation, while zinc did not have any effect. Moreover, strontium significantly enhanced and silicon inhibited CP cement degradation, while other bioinorganic supplementations generally did not promote material degradation at all [ 29 ].…”

Section: Calcium Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

et al. 2021

View full text Add to dashboard Cite

Alloplasts are synthetic, inorganic, biocompatible bone substitutes that function as defect fillers to repair skeletal defects. The acceptance of these substitutes by host tissues is determined by the pore diameter and the porosity and inter-connectivity. This narrative review appraises recent developments, characterization, and biological performance of different synthetic materials for bone, periodontal, and dental tissue regeneration. They include calcium phosphate cements and their variants β-tricalcium phosphate (β-TCP) ceramics and biphasic calcium phosphates (hydroxyapatite (HA) and β-TCP ceramics), calcium sulfate, bioactive glasses and polymer-based bone substitutes which include variants of polycaprolactone. In summary, the search for synthetic bone substitutes remains elusive with calcium compounds providing the best synthetic substitute. The combination of calcium sulphate and β-TCP provides improved handling of the materials, dispensing with the need for a traditional membrane in guided bone regeneration. Evidence is supportive of improved angiogenesis at the recipient sites. One such product, (EthOss® Regeneration, Silesden UK) has won numerous awards internationally as a commercial success. Bioglasses and polymers, which have been used as medical devices, are still in the experimental stage for dental application. Polycaprolactone-TCP, one of the products in this category is currently undergoing further randomized clinical trials as a 3D socket preservation filler. These aforementioned products may have vast potential for substituting human/animal-based bone grafts.

show abstract

Section: Calcium Compoundsmentioning

confidence: 99%

Section: Calcium Compoundsmentioning

confidence: 99%

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Nanosized HA also receives the name HA nanoparticles and possesses a grain size of less than 100 nm in at least one dimension. HA nanoparticles display a high surface area and a fine nanostructure, close to that of the mineral discovered in hard tissues [10]. Indeed, the bioceramics which rapidly stimulate osteointegration and bone tissue generation are those that imitate the composition and structure of the bone mineral.…”

Section: Introductionmentioning

confidence: 95%

Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review

et al. 2022

View full text Add to dashboard Cite

Additive manufacturing (AM), frequently cited as three-dimensional (3D) printing, is a relatively new manufacturing technique for biofabrication, also called 3D manufacture with biomaterials and cells. Recent advances in this field will facilitate further improvement of personalized healthcare solutions. In this regard, tailoring several healthcare products such as implants, prosthetics, and in vitro models, would have been extraordinarily arduous beyond these technologies. Three-dimensional-printed structures with a multiscale porosity are very interesting manufacturing processes in order to boost the capability of composite scaffolds to generate bone tissue. The use of biomimetic hydroxyapatite as the main active ingredient for bioinks is a helpful approach to obtain these advanced materials. Thus, 3D-printed biomimetic composite designs may produce supplementary biological and physical benefits. Three-dimensional bioprinting may turn to be a bright solution for regeneration of bone tissue as it enables a proper spatio-temporal organization of cells in scaffolds. Different types of bioprinting technologies and essential parameters which rule the applicability of bioinks are discussed in this review. Special focus is made on hydroxyapatite as an active ingredient for bioinks design. The goal of such bioinks is to reduce the constraints of commonly applied treatments by enhancing osteoinduction and osteoconduction, which seems to be exceptionally promising for bone regeneration.

show abstract

“…Positive effects of Sr on osteoporosis and osteoarthritis were reported. [22,23] One of the important properties of Sr, causing a high interest in materials research, is its osteoinductivity. Sr has a dual effect on bone remodeling.…”

Section: Introductionmentioning

confidence: 99%

“…[38,39] In the case of Sr-DCPD, there is a cumulative effect of Sr on osteogenesis and a higher rate of DCPD bioresorption compared to HA cements. [23] As a precursor for the brushite cements preparation, β-tricalcium phosphate (β-TCP, β-Ca 3 (PO 4 ) 2 ) or, in this case, Sr-β-TCP, [40] is mainly used. A number of studies were devoted to Sr-substituted brushite cements.…”

Section: Introductionmentioning

confidence: 99%

Strontium Substituted Tricalcium Phosphate Bone Cement: Short and Long‐Term Time‐Resolved Studies and In Vitro Properties

Rau

Фадеева

Forysenkova

et al. 2022

Adv Materials Inter

View full text Add to dashboard Cite

show abstract

Bioinorganic supplementation of calcium phosphate-based bone substitutes to improvein vivoperformance: a systematic review and meta-analysis of animal studies

Abstract: Supplementation of CaP-based bone substitutes with bioinorganics affects biological performance.

Cited by 19 publications

References 144 publications

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review

Strontium Substituted Tricalcium Phosphate Bone Cement: Short and Long‐Term Time‐Resolved Studies and In Vitro Properties

Contact Info

Product

Resources

About