Bioinorganic Chemistry of Zinc in Relation to the Immune System

Kepp, Kasper Planeta

doi:10.1002/cbic.202100554

Cited by 10 publications

(6 citation statements)

References 285 publications

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“…Zinc has an important role in normal host immune function 34 . At a cellular level, macrophages can adopt divergent strategies of both zinc starvation and zinc toxicity to kill the bacteria they engulf.…”

Section: Metals and Bacteriamentioning

confidence: 99%

Metals to combat antimicrobial resistance

et al. 2023

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Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions have a long history of antimicrobial activity and have received increasing attention in recent years owing to the rise of antimicrobial resistance. The search for antibacterial agents now encompasses metal ions, nanoparticles and metal complexes with antimicrobial activity (‘metalloantibiotics’). Although yet to be advanced to the clinic, metalloantibiotics are a vast and underexplored group of compounds that could lead to a much-needed new class of antibiotics. This Review summarizes recent developments in this growing field, focusing on advances in the development of metalloantibiotics, in particular, those for which the mechanism of action has been investigated. We also provide an overview of alternative uses of metal complexes to combat bacterial infections, including antimicrobial photodynamic therapy and radionuclide diagnosis of bacterial infections.

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Section: Metals and Bacteriamentioning

confidence: 99%

Metals to combat antimicrobial resistance

et al. 2023

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“…However, when we evaluate the relationship with living organisms, it can easily be noticed that zinc is the second most abundant transition ion in the series of essential elements, indispensable for a huge number of biological processes. This trace element is critical for cell growth, genomic stability, signal transcription factors, and for the structure and function of a wide range of cellular proteins [ 1 , 2 , 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Characteristics such as fast ligand exchange, stereochemical flexibility, and redox inertness sustain its selection in the function of numerous proteins [ 6 ]. For these biomolecules, Zn(II) acts mainly as a Lewis acid for enzymes involved in hydrolytic process regulation, as well as a structural factor in both nucleic acid synthesis and their activity control [ 1 , 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

et al. 2023

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This review considers the applications of Zn(II) carboxylate-based coordination polymers (Zn-CBCPs), such as sensors, catalysts, species with potential in infections and cancers treatment, as well as storage and drug-carrier materials. The nature of organic luminophores, especially both the rigid carboxylate and the ancillary N-donor bridging ligand, together with the alignment in Zn-CBCPs and their intermolecular interaction modulate the luminescence properties and allow the sensing of a variety of inorganic and organic pollutants. The ability of Zn(II) to act as a good Lewis acid allowed the involvement of Zn-CBCPs either in dye elimination from wastewater through photocatalysis or in pathogenic microorganism or tumor inhibition. In addition, the pores developed inside of the network provided the possibility for some species to store gaseous or liquid molecules, as well as to deliver some drugs for improved treatment.

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“…In the previous section, the role of zinc was discussed as an inducer of ferroptosis. Zinc occurs as a cofactor in numerous human enzymes of all six main classes and plays either a structural or regulatory role in up to 10% of human proteins [ 140 ]. The pro-ferroptotic effects reported upon zinc induction are strikingly similar to what has been reported in the case of arsenite.…”

Section: Poisons and Toxicantsmentioning

confidence: 99%

Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings

Bartos

Sikora

2023

IJMS

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Ferroptosis was first reported as a separate modality of regulated cell death in 2008 and distinguished under its current name in 2012 after it was first induced with erastin. In the following decade, multiple other chemical agents were researched for their pro- or anti-ferroptotic properties. Complex organic structures with numerous aromatic moieties make up the majority of this list. This review fills a more overlooked niche by gathering, outlining and setting out conclusions regarding less prominent cases of ferroptosis induced by bioinorganic compounds and reported on within the last few years. The article contains a short summary of the application of bioinorganic chemicals based on gallium, several chalcogens, transition metals and elements known as human toxicants used for the purpose of evoking ferroptotic cell death in vitro or in vivo. These are used in the form of free ions, salts, chelates, gaseous and solid oxides or nanoparticles. Knowledge of how exactly these modulators promote or inhibit ferroptosis could be beneficial in the context of future therapies aimed against cancer or neurodegenerative diseases, respectively.

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Bioinorganic Chemistry of Zinc in Relation to the Immune System

Cited by 10 publications

References 285 publications

Metals to combat antimicrobial resistance

Metals to combat antimicrobial resistance

Zinc(II) Carboxylate Coordination Polymers with Versatile Applications

Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings

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