Bioinformatics Study of Turmeric (Curcuma Domestica Val) Againts Arthritis Gout Disease

Abstract

Degenerative diseases are developing today. One of them is gouty arthritis, also known as gout. This disease is very common in society. In Indonesia, the prevalence of gouty arthritis is 34-32 years old. According to a report from the Padang City Health Office in 2018, gouty arthritis was ranked the 4th highest disease in the city of Padang after gastritis. The highest prevalence was in North Padang District with 400 sufferers and Alai Health Center ranked 2nd with 118 cases. Gouty arthritis is characterized by high levels of uric acid in the blood (hyperuricemia). Arthritis is rarely fatal, but can be stressful for patients. The therapy used is anti-inflammatory drugs with many side effects. Turmeric (Curcuma longa) is one of the herbal plants that has the potential to treat rheumatism and gout. Turmeric (Curcuma domestica Val) is an herbal plant with anti-inflammatory properties for gouty arthritis. The large old turmeric rhizome is often used as medicine. Turmeric contains the active ingredient curcumin. It has been extensively studied as an anti-inflammatory drug. This is because curcumin can inhibit the protein Cyclooxygenase-2 (COX-2). COX-2 is an enzyme that mediates inflammation. Therefore, the curcumin in turmeric has a potential anti-inflammatory effect and can be used as the basis for the treatment of artritis gout.