Bioinformatics, Molecular Docking Simulation and in vitro Experiments Reveal the Bioactive Compounds and Mechanism of Coptis chinensis Franch. Against Colorectal Adenocarcinoma
Xin Liu,
Xu-ying Huang,
Zhong Liu
et al.
Abstract:Background Coptis Chinensis Franch. (CCF) is a traditional Chinese medicine known for its good anti-cancer effects. However, the bioactive compounds and mechanisms underlying its anti-colorectal adenocarcinoma (COAD) remains unclear. Objectives This study aims to reveal the bioactive compounds and mechanism of CCF against COAD by utilizing bioinformatics, molecular docking simulation and in vitro experiments. Materials and Methods Bioactive compounds and candidate targets of CCF against COAD were collected usi… Show more
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