Bioinformatics models in drug abuse and Neuro-AIDS: Using and developing databases

Shapshak, Paul; Duncan, Robert C.; Turchan, Jadwiga; Nath, Avindra; Minagar, Alireza; Kangueane, Pandjassarame; Davis, W. Sumner; Chiappelli, Francesco; Elkomy, Fatten; Seth, Raman; Kazic, Toni

doi:10.6026/97320630001086

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…The digital technique to evaluate resistance towards a drug can be employed in other drug resistance studies to develop a computer-aided drug resistance calculator. Databases can be developed to interpret molecular associations in order to evaluate drug abuse and Neuro-AIDS [46]. Effective evaluation of gene expression interactions can aid in better understanding the depth and intensity of the problems.…”

Section: Discussion Of Methods Tools and Databases Based On Translational Bioinformaticsmentioning

confidence: 99%

Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry

Behl

Kaur

Sehgal

et al. 2021

IJMS

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With advanced technology and its development, bioinformatics is one of the avant-garde fields that has managed to make amazing progress in the pharmaceutical–medical field by modeling the infrastructural dimensions of healthcare and integrating computing tools in drug innovation, facilitating prevention, detection/more accurate diagnosis, and treatment of disorders, while saving time and money. By association, bioinformatics and pharmacovigilance promoted both sample analyzes and interpretation of drug side effects, also focusing on drug discovery and development (DDD), in which systems biology, a personalized approach, and drug repositioning were considered together with translational medicine. The role of bioinformatics has been highlighted in DDD, proteomics, genetics, modeling, miRNA discovery and assessment, and clinical genome sequencing. The authors have collated significant data from the most known online databases and publishers, also narrowing the diversified applications, in order to target four major areas (tetrad): DDD, anti-microbial research, genomic sequencing, and miRNA research and its significance in the management of current pandemic context. Our analysis aims to provide optimal data in the field by stratification of the information related to the published data in key sectors and to capture the attention of researchers interested in bioinformatics, a field that has succeeded in advancing the healthcare paradigm by introducing developing techniques and multiple database platforms, addressed in the manuscript.

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Section: Discussion Of Methods Tools and Databases Based On Translational Bioinformaticsmentioning

confidence: 99%

Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry

Behl

Kaur

Sehgal

et al. 2021

IJMS

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“…In particular, these disciplines may be useful to further clarify the pathophysiology of complex diseases, which are characterized by various biologic pathways, dependent upon the contribution of a large number of genes forming complex networks of interactions [7, 8]. We (FC in Shapshak et al, 2006) provided a preliminary description of the molecular mechanisms underlying these processes using expression and gene annotation data [9]. This information has been stored in a user friendly, online database that, when made available in the public domain, will enable scientists to retrieve biochemical and physiological information on neuro-degeneration in HIVinfected patients.…”

Section: Novel Approaches For the Analysis Of The Molecular Events Unmentioning

confidence: 99%

“…This information has been stored in a user friendly, online database that, when made available in the public domain, will enable scientists to retrieve biochemical and physiological information on neuro-degeneration in HIVinfected patients. They are also developing methods to structure anatomical information (location where specific biochemical reactions occur) so that essential structural features are included along with the topological attributes [9]. …”

Section: Novel Approaches For the Analysis Of The Molecular Events Unmentioning

confidence: 99%

New tools for the investigations of Neuro-AIDS at a molecular level: The potential role of data-mining

Orlando

Giacomelli²,

Chiappelli

et al. 2013

Bioinformation

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Cognitive impairment represents the most significant and devastating neurological complication associated with HIV infection. Despite recent advances in our knowledge of the clinical features, pathogenesis, and molecular aspects of HIV-related dementia, current diagnostic strategies are associated with significant limitations. It has been suggested that the use of some biomarkers may assist researchers and clinicians in predicting the onset of the disease process and in evaluating the effects of new therapies. However, the large number of chemicals and metabolic pathways involved in the pathogenesis of neurodegeneration, warrants the development of novel approaches to integrate this huge amount of data. The contribution of theoretical disciplines, such as bioinformatics and data-mining, may be useful for testing new hypotheses in diagnosis and patient-centered treatment interventions.

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“…[135,[233][234][235][236][237][238][239] Finally, the sion profiles in neurons themselves, which are deleterious to their clinical definitions and nosology of HAD and HIV-associated function. [135,[233][234][235][236][237][238][239] Finally, the sion profiles in neurons themselves, which are deleterious to their clinical definitions and nosology of HAD and HIV-associated function.…”

Section: Advantages and Disadvantages Ofmentioning

confidence: 99%

NeuroAIDS

et al. 2008

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The neurological complications of AIDS (NeuroAIDS) include neurocognitive impairment and HIV-associated dementia (HAD; also known as AIDS dementia and HIV encephalopathy). HAD is the most significant and devastating central nervous system (CNS) complications associated with HIV infection. Despite recent advances in our knowledge of the clinical features, pathogenesis, and neurobiological aspects of HAD, it remains a formidable scientific and therapeutic challenge. An understanding of the mechanisms of HIV neuroinvasion, CNS proliferation, and HAD pathogenesis provide a basis for the interpretation of the diagnostic features of HAD and its milder form, HIV-associated minor cognitive/motor disorder (MCMD). Current diagnostic strategies are associated with significant limitations, but it is hoped that the use of biomarkers may assist researchers and clinicians in predicting the onset of the disease process and in evaluating the effects of new therapies.

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Bioinformatics models in drug abuse and Neuro-AIDS: Using and developing databases

Cited by 8 publications

References 24 publications

Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry

Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry

New tools for the investigations of Neuro-AIDS at a molecular level: The potential role of data-mining

NeuroAIDS

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