Bioinformatics as a Tool to Identify Infectious Disease Pathogen Peptide Sequences as Targets for Antibody Engineering

Abstract

Bioinformatics is an interdisciplinary field of information technology for understanding biological data from genome to protein. It includes a combination of fields of science, computer science, statistics, mathematics, and engineering to analyze, interpret and derive biological data. This chapter describes how to use Bioinformatics to identify pathogen virulence factor peptide sequence similarities in human nerve tissue proteins and for evaluation as antibody engineering target peptides.

Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins

“…The hypothesis is that sequence and structural similarities (mimics) that exist in the host nerve and pathogen proteins include significant host-pathogen cross reactions - i.e. in receptor binding, steric hindrance, signalling/transmission, metabolic alteration, inflammation and auto-antibody production, which could ultimately lead to aberrant development of neurons and neuropathy [ 19 , 20 ]. To assess whether such sequence similarities /molecular mimics occurred between the Zika V and the human host, we compared the peptide sequence of 63 proteins expressed in the human nerve tissue with that of the peptide sequence of the Zika V polyprotein with the use of bioinformatic tools.…”

A Review on Seismic Response of High Rise Building Having Diaphragm Discontinuity

“…P.Suneetha [4] , "Effect of Diaphragm Discontinuity". Many buildings in the present scenario have irregular configurations both in elevation and plan.…”