Bioinformatics approach to identify the core ontologies, pathways, signature genes and drug molecules of prostate cancer

Hossain, Md. Bipul; Adhikary, Apurba; Islam, Imtia; Hossain, Mohammad Amzad; Uddin, K. M. Aslam; Bristy, Sadia Afrin; Rahman, Habibur

doi:10.1016/j.imu.2023.101179

Cited by 1 publication

(1 citation statement)

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“…The data were systematically reviewed to pinpoint significantly upregulated or downregulated DEGs. We delved deeper to ascertain the pathways most affected by these changes, their components, and the associated signaling networks [51]. The gene set enrichment analysis (GSEA) was conducted using Ingenuity Pathways Analysis (IPA) software (https://digitalinsights.qiagen.com/products-overview/discovery-insights-port folio/analysis-and-visualization/qiagen-ipa/# accessed on 8 January 2024) and its knowledge database [52].…”

Section: Gene Set Enrichment and Network Analysismentioning

confidence: 99%

Integrative Bioinformatics–Gene Network Approach Reveals Linkage between Estrogenic Endocrine Disruptors and Vascular Remodeling in Peripheral Arterial Disease

Avecilla,

Doke,

Das

et al. 2024

IJMS

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Vascular diseases, including peripheral arterial disease (PAD), pulmonary arterial hypertension, and atherosclerosis, significantly impact global health due to their intricate relationship with vascular remodeling. This process, characterized by structural alterations in resistance vessels, is a hallmark of heightened vascular resistance seen in these disorders. The influence of environmental estrogenic endocrine disruptors (EEDs) on the vasculature suggests a potential exacerbation of these alterations. Our study employs an integrative approach, combining data mining with bioinformatics, to unravel the interactions between EEDs and vascular remodeling genes in the context of PAD. We explore the molecular dynamics by which EED exposure may alter vascular function in PAD patients. The investigation highlights the profound effect of EEDs on pivotal genes such as ID3, LY6E, FOS, PTP4A1, NAMPT, GADD45A, PDGF-BB, and NFKB, all of which play significant roles in PAD pathophysiology. The insights gained from our study enhance the understanding of genomic alterations induced by EEDs in vascular remodeling processes. Such knowledge is invaluable for developing strategies to prevent and manage vascular diseases, potentially mitigating the impact of harmful environmental pollutants like EEDs on conditions such as PAD.

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Section: Gene Set Enrichment and Network Analysismentioning

confidence: 99%